A5101561318- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- IL-33, ST2, and ILC Pathways
- Asthma and respiratory diseases
- Extracellular vesicles in disease
- Tumors and Oncological Cases
- Immune cells in cancer
- Reproductive System and Pregnancy
- SARS-CoV-2 and COVID-19 Research
- Autoimmune and Inflammatory Disorders Research
- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
- Inflammatory Myopathies and Dermatomyositis
- Vascular Tumors and Angiosarcomas
- Cutaneous lymphoproliferative disorders research
- Facial Rejuvenation and Surgery Techniques
- Dupuytren's Contracture and Treatments
- Facial Nerve Paralysis Treatment and Research
- Autoimmune and Inflammatory Disorders
- IgG4-Related and Inflammatory Diseases
- Mental Health Research Topics
- Ocular Oncology and Treatments
- Systemic Lupus Erythematosus Research
Guangzhou Medical University
2020-2024
Shanghai Tenth People's Hospital
2014-2023
Tongji University
2014-2023
Tianjin Medical University
2022-2023
Fudan University
2023
Zhongshan Hospital
2023
Shanghai Skin Disease Hospital
2022
Guangzhou Women and Children Medical Center
2021
Second Affiliated Hospital of Zhejiang University
2021
Renji Hospital
2013
Intrahepatic cholangiocarcinoma (ICC) is a common malignancy arising from the liver with limited 5-year survival. Thus, there an urgency to explore new treatment methods. Chimeric antigen receptor T (CAR T) cell therapy very promising cancer treatment. Though, several groups have investigated CAR cells targeting MUC1 in solid models, Tn-MUC1-targeted not yet be reported ICC. In this study, we confirmed Tn-MUC1 as potential therapeutic target for ICC and demonstrated that its expression level...
The important pathophysiological role of immune dysfunction, especially innate dysfunction in patients with acute-on-chronic liver failure (ACLF), has been investigated recent years, but dysregulation adaptive immunity remains poorly elucidated. aim this study was to (i) determine the CD3(+) T-lymphocyte count and balance between CD4(+) regulatory T (Tregs) conventional cells (Tconv) hepatitis B virus (HBV)-related ACLF patients; (ii) analyse frequencies Tregs subpopulations; (iii) assess...
Substance abuse has been a public health concern, and even after detoxification treatment, the relapse rate is still high. Family function closely related to substance dependence. However, studies on psychological mechanisms between them are rare.We aimed explore mediating role of self-esteem resilience in pathway that family impacts tendency among patients with use disorder (SUD).A total 282 SUD were recruited, standard questionnaires administered for each patient. The tendency, function,...
Psoriasis is a chronic inflammatory skin disorder that impairs the quality of life affected patients. Emerging studies indicate certain long non-coding RNAs (lncRNAs) have important roles in psoriasis. However, exact functions lncRNAs and their regulatory mechanisms as competitive endogenous (ceRNAs) psoriasis remained to be fully elucidated. In present study, differentially expressed lncRNAs, microRNAs (miRNAs) mRNAs were identified by analyzing public datasets, psoriasis-associated...
Summary Psoriasis is a chronic inflammatory skin disease with unclear pathogenesis. Interleukin‐33 (IL‐33) highly expressed in patients psoriasis, but its role psoriasis unknown. The aim of this study was to investigate the possible IL‐33 pathogenesis and treatment psoriasis. expression determined using enzyme‐linked immunosorbent assay, real‐time fluorescent quantitative polymerase chain reaction immunohistochemical staining. CD4 + T cells were sorted magnetic beads treated or without...
Background: Reactive perforating collagenosis (RPC) is a rare form of transepithelial elimination, in which altered collagen extruded through the epidermis. There are 2 types RPC, acquired RPC (ARPC) and inherited while latter extremely rare. Here we report on 1 case ARPC. Methods: A 73-year-old female was presented with strongly itchy papules over her back lower limbs for 3 months. She denied history oozing or vesiculation. cutaneous examination showed diffusely distributed multiple...
Background: Psoriasis is a common immune-mediated skin disease that involves T-cell-mediated immunity. Invariant natural killer T (iNKT) cells are unique lymphocyte subpopulation share properties and express surface markers of both NK cells. Previous reports indicate iNKT regulate the development various inflammatory diseases. IL-17 key cytokine in pathogenesis psoriasis therapeutic target. Secukinumab fully human IgG1κ antibody targets IL-17A, thereby antagonizing biological effects IL-17....
Photodynamic therapy (PDT) has been widely used in treatment for skin cancer. However, topical 5-aminolevulinic acid (ALA) PDT demonstrates poor therapeutic effect due to its shallow penetration. And intralesional ALA-PDT can bring great pain. The purpose of this study was evaluate the efficacy with needle-free injection ALA nonmalignant tumors.54 non-melanocytic malignant lesions 54 subjects were treated 20% 5-ALA under occlusion 1.5 hours, and irradiated light dose 100 J/cm(2) at mW 20...
Psoriasis (PS) is a systemic, immune-mediated inflammatory disorder. However, the whole lymphocyte compartment and potential pathologies of PS have not been fully characterized. In present study, we examined subsets signal transduction proteins using high-dimensional single-cell mass cytometry bioinformatics pipeline for an in-depth characterization immune cell protein profiles involved in pathways peripheral blood patients with PS. We identified 15 major populations T lineages characterized...
Malignant acanthosis nigricans (MAN), characterized by the presence of a hyperpigmented, velvety cutaneous thickening, is recognized as sign internal malignancy. Few MAN has been reported in Asian race ever before. Here, we report rare case with severe mucosa and soles extraordinary facial involvement race. A 74-year-old man presented hyperkeratotic eruption for 7 months. Physical examination revealed plaques on face, dorsal skin fingers heels, papillomatosis buccal mucosa. Biopsy findings...
Abstract: Cutaneous metastasis from primary visceral malignancy is a relatively uncommon clinical entity, with reported incidence ranging 0.22% to 12% of all malignancies. Here we report 64-year-old asymptomatic female patient Peutz–Jeghers syndrome presenting multiple scalp metastases as the initial manifestation secondary lung adenocarcinoma. Subsequent computed tomography scan showed large masses involving left upper lobe associated extensive mediastinal lymphadenopathy. After treatment...
Abstract Background Hyaluronic acid (HA) fillers are known to be effective for the correction of facial wrinkles and folds, but there is no clinical study that compares efficacy small‐to‐medium‐particle HA large‐particle nasolabial folds (NLFs). Moreover, injection depth also plays an important role in NLFs as well improvement aesthetics. Objectives To assess efficacy, safety, durability a filler, Restylane, Yishumei, effect moderate‐to‐severe aesthetics Chinese population. Methods This...
Introduction Herein, we developed an engineered extracellular vehicle (EV)-based method for ameliorating inflammatory responses in psoriasis.Methods EVs, derived from annexin A1 (ANXA1) overexpressing T cells, were co-extruded with M2 macrophage membrane to obtain EVs. In vitro, the effect of EVs on polarization was evaluated by real-time PCR. imiquimod (IMQ)-induced psoriasis-like mouse model, efficacy psoriatic inflammation Psoriasis Area and Severity Index (PASI) score...