A5078490704- Bone Metabolism and Diseases
- Tendon Structure and Treatment
- Bone health and treatments
- Osteoarthritis Treatment and Mechanisms
- Advanced biosensing and bioanalysis techniques
- Bone Tissue Engineering Materials
- Spine and Intervertebral Disc Pathology
- Knee injuries and reconstruction techniques
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- NF-κB Signaling Pathways
- Liver Disease Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Liver physiology and pathology
- Bone health and osteoporosis research
- Mesenchymal stem cell research
- Shoulder Injury and Treatment
- Retinoids in leukemia and cellular processes
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Sports injuries and prevention
- ATP Synthase and ATPases Research
- Orthopedic Infections and Treatments
- Wound Healing and Treatments
- Inflammasome and immune disorders
Guangzhou University of Chinese Medicine
2025
Guangzhou Medical University
2020-2025
Zhongshan Hospital of Xiamen University
2015-2025
Anhui Science and Technology University
2025
Hangzhou Medical College
2022-2025
Zhejiang Provincial People's Hospital
2022-2025
Anhui University of Science and Technology
2025
Universitätsklinikum Erlangen
2020-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2020-2024
Wenzhou Medical University
2014-2024
Type 2 diabetic osteoporosis (T2DOP) is a chronic bone metabolic disease. Compared with traditional menopausal osteoporosis, the long-term high glucose (HG) microenvironment increases patients' risk of fracture and osteonecrosis. We were accumulating evidence that implicated ferroptosis as pivotal mechanism glucolipotoxicity-mediated death osteocytes osteoblast, novel form programmed cell resulting from uncontrolled lipid peroxidation depending on iron. Vitamin K2 (VK2), fat-soluble vitamin,...
Abstract Chondrocyte phenotype has been shown to dedifferentiate during passaged monolayer cultivation. Hence, we have investigated the expression profile of 27 chondrocyte‐associated genes from both osteoarthritic cartilage tissue and healthy human articular chondrocytes by quantitative real‐time PCR. Our results indicate that gene levels matrix proteins proteases in culture decrease compared with those tissue, while cultured normal exhibit similar patterns. However, chondrocytic profiles...
Growing evidence indicates that inflammation has a crucial role in the development and progression of cancer. We developed novel systemic score (SIS) based on preoperative serum albumin lymphocyte-to-monocyte ratio (LMR), examined its prognostic value for patients with clear-cell renal cell carcinoma (ccRCC) after surgery. The study comprised 441 ccRCC undergoing nephrectomy between 2008 2009 single centre. SIS was associations clinicopathological features overall survival (OS) were...
Identification of functional programmable mechanical stimulation (PMS) on tendon not only provides the insight homeostasis under physical/pathological condition, but also guides a better engineering strategy for regeneration. The aims study are to design bioreactor system with PMS mimic in vivo loading conditions, and define impact different cyclic tensile strain tendon. Rabbit Achilles tendons were loaded with/without (0.25 Hz 8 h/day, 0-9% 6 days). Tendons without lost its structure...
The selection of a suitable scaffold matrix is critical for cell-based bone tissue engineering.This study aimed to identify and characterize natural marine sponges as potential bioscaffolds osteogenesis.Callyspongiidae sponge samples were collected from the Fremantle coast Western Australia.The structure was assessed using scanning electron microscopy (SEM) Hematoxylin eosin.Mouse primary osteoblasts seeded onto immunostained with F-actin assess cell attachment aggregation.Alkaline...
Background: Tendinopathy of the Achilles tendon is a chronic degenerative condition that frequently does not respond to treatment. In current study, we propose autologous tenocytes therapy (ATT) effective in treating degeneration collagenase-induced rabbit tendinopathy model. Methods: Chronic was created left 44 rabbits by an intratendonous injection type I collagenase. Forty-two were randomly allocated into three groups 14 and received control treatment; digested from tissue; epitendineum...
Osteoclasts play a pivotal role in diseases such as osteoporosis, rheumatoid arthritis and tumour bone metastasis. Thus, searching for natural compounds that may suppress osteoclast formation and/or function is promising the treatment of osteoclast-related diseases. Here, we examined changes osteoclastogenesis LPS-induced osteolysis response to andrographolide (AP), diterpenoid lactone isolated from traditional Chinese Indian medicinal plant Andrographis paniculata.Effects AP on...
To improve water solubility and bioavailability, curcumin (Cur) was encapsulated by liposomes (Cur-Lip), which further coated with thiolated chitosan (CSSH) to form liposomal hydrogels (CSSH/Cur-Lip gel). The were thermosensitive in situ injectable performance, fluidic at room temperature gelled quickly 37 °C. cumulative release ratio of the 200 μM CSSH/Cur-Lip gel 31.57 ± 1.34% 12 h, could effectively delay curcumin. Worthily, resilient compressive even after five cycles compression....
Declining estrogen production in postmenopausal females causes osteoporosis which the resorption of bone exceeds increase formation. Although clinical drugs are currently available for treatment osteoporosis, sustained medication use is accompanied by serious side effects.
Microfluidic-based single cells analysis has been of great interest in recent years, promising disease diagnosis and personalized medicine. Current technologies are challenging bioselectively isolating specific from complex matrices. Herein, a novel microfluidic platform integrated with cell-recognizable aptamer-encoded microwells was specifically developed to isolate tumor satisfied single-cell occupancy unique bioselectivity. In this work, the designed microwell-structures enable us...
Background: Severe chronic lateral epicondylitis (LE) is associated with degenerative tendon changes, extracellular matrix breakdown, and cell loss. On the basis of positive outcomes from preclinical studies, this study first clinical trial autologous tenocyte injection (ATI) on severe tendinopathy LE. Hypothesis: Autologous a safe effective procedure that enables reduction in pain improvement function resistant Study Design: Case series; Level evidence, 4. Methods: Patients refractory LE...
Wear particle-induced peri-implant loosening (Aseptic prosthetic loosening) is one of the most common causes total joint arthroplasty. It well established that extensive bone destruction (osteolysis) by osteoclasts responsible for wear loosening. Thus, inhibition osteoclastic resorption should prevent particle induced osteolysis and may serve as a potential therapeutic avenue Here, we demonstrate first time saliphenylhalamide, new V-ATPase inhibitor attenuates in mouse calvarial model. In...
Abstract This study investigates therapeutic efficacy of photothermal therapy (PTT) in an orthotropic xenograft model bone metastasis breast cancer. The near-infrared (NIR) irradiation on Multi-Walled Carbon Nanotubes (MWNTs) resulted a rapid heat generation which increased with the MWNTs concentration up to 100 μg/ml. alone exhibited no toxicity, but inclusion dramatically decreased cell viability when combined laser irradiation. Thermographic observation revealed that treatment 10 μg...