Le Xu

ORCID: 0000-0002-1856-1856
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About
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Research Areas
  • Endometriosis Research and Treatment
  • Reproductive System and Pregnancy
  • Pregnancy and preeclampsia studies
  • Genetic and Kidney Cyst Diseases
  • Renal cell carcinoma treatment
  • Cancer Mechanisms and Therapy
  • Uterine Myomas and Treatments
  • Urinary and Genital Oncology Studies
  • Ovarian cancer diagnosis and treatment
  • Endometrial and Cervical Cancer Treatments
  • MRI in cancer diagnosis
  • Inflammatory Biomarkers in Disease Prognosis
  • Cancer Immunotherapy and Biomarkers
  • Bladder and Urothelial Cancer Treatments
  • Flavonoids in Medical Research
  • Cytokine Signaling Pathways and Interactions
  • Ureteral procedures and complications

Ruijin Hospital
2025

Shanghai Jiao Tong University
2025

Yangzhou Municipal Meteorological Bureau
2025

Sun Yat-sen Memorial Hospital
2025

Sun Yat-sen University
2025

Shandong Provincial Hospital
2023-2024

Shandong University
2015-2024

Shandong First Medical University
2023

Bengbu Medical College
2021

Shandong Provincial QianFoShan Hospital
2015

Growing evidence indicates that inflammation has a crucial role in the development and progression of cancer. We developed novel systemic score (SIS) based on preoperative serum albumin lymphocyte-to-monocyte ratio (LMR), examined its prognostic value for patients with clear-cell renal cell carcinoma (ccRCC) after surgery. The study comprised 441 ccRCC undergoing nephrectomy between 2008 2009 single centre. SIS was associations clinicopathological features overall survival (OS) were...

10.1038/bjc.2015.241 article EN cc-by-nc-sa British Journal of Cancer 2015-07-02

The E3 ubiquitin ligase murine double minute 2 (MDM2) binds the p53 transcriptional activation domain and acts as a potent inhibitor of TP53 pathway, one three most crucial oncogenic pathways in urothelial carcinoma (UC). However, clinical significance impact on tumor immune contexture MDM2 amplification UC remain unclear. This study analyzed 240 patients with matched annotations from two local cohorts (ZSHS cohort FUSCC cohort). We assessed correlation between status outcomes, therapeutic...

10.1136/jitc-2024-010964 article EN cc-by-nc-nd Journal for ImmunoTherapy of Cancer 2025-01-01

Abstract The severe convective weather threatening chemical parks, including gale winds, torrential rain, and thunderstorms, can lead to complex disaster chains. This paper presents an integrated risk assessment method for such disasters, employing decomposition analysis, AHP, the Risk Matrix Model. It precisely identifies high‐risk zones, prioritizing safety measures targeted protection. Rooted in meteorological assessment, this considers production, handling, storage, toxicity of hazardous...

10.1002/cepa.3282 article EN ce/papers 2025-03-01

The pathogenesis of adenomyosis is closely related to the epithelial-mesenchymal transition and macrophages. MicroRNAs have been extensively investigated in relation a range malignancies. However, there paucity research on extracellular vesicles derived from eutopic endometrium their encapsulated microRNAs. In this study, we role microRNA-25-3p inducing macrophage polarization promoting endometrial epithelial cells patients with controls. We obtained samples isolated culture supernatant...

10.1093/molehr/gaae010 article EN Molecular Human Reproduction 2024-02-23

The aim of parapelvic cyst treatment is to have complete drainage fluid and prevent its further compression the kidney collective system. This study explores efficacy safety surgical approaches with holmium laser ureteroscopic internal in cyst.The effect on renal system was observed by rigid ureteroscope using retrograde technology. With direct vision, wall obvious site cut. diameter cut about 1 cm. obtained double-J tubes. When inferior pole or where could not reach, a flexible used.In 28...

10.7727/wimjopen.2014.220 article EN West Indian Medical Journal 2015-01-01

Abstract Ferroptosis is an iron-dependent programmed cell death process characterized by the accumulation of lethal oxidative damage. Localized iron overload a unique clinical phenomenon in ovarian endometriosis (EM). However, role and mechanism ferroptosis course EM remain unclear. Traditionally, autophagy promotes survival. growing body research suggests that under certain conditions. This study aimed to clarify status explore mechanism(s) which causes ectopic endometrial resistance human....

10.1093/molehr/gaad046 article EN Molecular Human Reproduction 2023-12-19

Abstract The development of endometriosis is closely linked to macrophages, and the type M1 macrophage has been hypothesized play an inhibitory role in its progression. Escherichia coli induces polarization toward numerous diseases differs reproductive tract patients with without endometriosis; however, specific remains unknown. Therefore, this study, E. was selected as a stimulator induce effects on growth lesions vitro vivo were investigated using C57BL/6N female mice endometrial cells. It...

10.1093/molehr/gaad014 article EN Molecular Human Reproduction 2023-04-20

To explore the molecular mechanism mediating inhibitory effect of Chuanxiong Rhizoma against brain metastasis lung cancer using network pharmacology methods and docking.The chemical components their targets were obtained through Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. The relevant for screened GeneCards Clusterpro-filerR package was used to perform GO KEGG enrichment analysis. Cytoscape STRING database construct "active ingredient-target-disease" protein-protein...

10.12122/j.issn.1673-4254.2021.09.05 article EN PubMed 2021-08-31
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