A5102963809- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Genetic factors in colorectal cancer
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- Immune Cell Function and Interaction
- Wound Healing and Treatments
- Graphene and Nanomaterials Applications
- Collaboration in agile enterprises
- Flavonoids in Medical Research
- Redox biology and oxidative stress
- Barrier Structure and Function Studies
- Advanced Optical Network Technologies
- CAR-T cell therapy research
- Metal-Catalyzed Oxygenation Mechanisms
- Advanced Manufacturing and Logistics Optimization
- Organ Donation and Transplantation
- Biological Activity of Diterpenoids and Biflavonoids
Second Affiliated Hospital of Dalian Medical University
2024-2025
Dalian Medical University
2024-2025
Sichuan University
2024-2025
Bengbu Medical College
2021-2024
Beijing Tsinghua Chang Gung Hospital
2024
Tsinghua University
2023-2024
State Key Laboratory of Biotherapy
2024
Kunming Medical University
2024
Guangdong Pharmaceutical University
2024
West China Medical Center of Sichuan University
2024
Abstract Cancer cells are often addicted to serine synthesis support growth. How is regulated in cancer not well understood. We recently demonstrated protein arginine methyltransferase 1 (PRMT1) upregulated hepatocellular carcinoma (HCC) methylate and activate phosphoglycerate dehydrogenase (PHGDH), thereby promoting synthesis. However, the mechanisms underlying PRMT1 upregulation regulation of PRMT1-PHGDH axis remain unclear. Here, we show E3 ubiquitin ligase F-box-only 7 (FBXO7) inhibits...
Abstract Cancer cells cope with oxidative stress for their proliferation and metastasis by equipping antioxidant systems, among which the enzymes peroxiredoxins (PRDXs) play crucial roles. However, whether PRDXs exhibit nonenzymatic functions remains unclear. Here, it is shown that 1‐cysteine PRDX (PRDX6) upregulates nicotinamide N ‐methyltransferase (NNMT) to promote growth of ovarian cancer cells, independently PRDX6's enzymatic activities. Mechanistically, PRDX6 interacts NNMT prevent its...
Chidamide (CS055/HBI-8000, tucidinostat) has shown promising effects in the clinical treatment of various hematologic tumors. Diffuse large B-cell lymphoma (DLBCL) highly heterogeneous biological characteristics. There are complex mechanisms role chidamide DLBCL for in-depth study. It is essential to probe further into mechanism drug-tumor interactions as a guide application and understand occurrence progression DLBCL. In vitro vivo models were utilized determine on signaling pathways...
Almonertinib, a new third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, is highly selective to EGFR T790M-mutant non-small cell lung cancer (NSCLC). However, there no available information on the form and molecular mechanism of Almonertinib-induced death in NSCLC cells. Herein, CCK-8 colony formation assays, flow cytometry, electron microscopy, western blots assay showed that Almonertinib inhibited cells proliferation by inducing apoptosis autophagy which can...
To explore the mechanism that mediates effect of soybean isoflavones (SI) against cerebral ischemia/reperfusion (I/R) injury in light regulation regional blood flow (rCBF), ferroptosis, inflammatory response and blood-brain barrier (BBB) permeability.A total 120 male SD rats were equally randomized into sham-operated group (Sham group), I/R SI pretreatment (SI group). Focal was induced latter two groups using a modified monofilament occlusion technique, intraoperative changes real-time...
To explore the molecular mechanism mediating inhibitory effect of Chuanxiong Rhizoma against brain metastasis lung cancer using network pharmacology methods and docking.The chemical components their targets were obtained through Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. The relevant for screened GeneCards Clusterpro-filerR package was used to perform GO KEGG enrichment analysis. Cytoscape STRING database construct "active ingredient-target-disease" protein-protein...
Abstract Background Cancer-associated fibroblasts (CAF) play a critical role in promoting tumor growth, metastasis, and immune evasion. While numerous studies have investigated CAF, there remains paucity of research on their clinical application colorectal cancer (CRC). Methods In this study, we collected differentially expressed genes between CAF normal (NF) from previous CRC studies, utilized machine learning analysis to differentiate two distinct subtypes CRC. To enable practical...
We study the dynamic service provisioning in drop-and-continue optical networks based on point-to-multipoint transceivers (P2MP-TRXs), and leverage asymmetric subcarrier (SC) allocation SC-level reconfiguration to optimize resource utilization with low operational complexity.
To investigate the effect of aqueous extract Chuan Xiong Rhizoma (CR) on brain metastasis melanoma B16F10 cells in mice.
The Wnt/β-catenin pathway represents a promising therapeutic target for mitigating kidney fibrosis. Corin possesses the homologous ligand binding site [Frizzled-cysteine-rich domain (Fz-CRD)] similar to Frizzled proteins, which act as receptors Wnt. Fz-CRD has been found in eight different all of which, except corin, are known bind Wnt and regulate its signal transmission. We hypothesized that corin may inhibit signaling thereby reduce fibrogenesis. Reduced expression along with increased...
To investigate the effect of wine-processed Chuanxiong Rhizoma (WCR) for enhancing efficacy aumolertinib against xenografts epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) in brain nude mice.In a co-culture system hCMEC/D3 and PC9 NSCLC cells, aqueous extract WCR (2 mg/mL) combined with (10 20 μmol/L) on apoptosis cells was investigated using flow cytometry. The effects (0.5, 1, 2 transmembrane transport 8 μmol/L examined ABCB1-MDCK monolayer cells. Western...
<title>Abstract</title> Objective This study aims to investigate the association between DKC1 expression and prognosis in head neck squamous cell carcinoma (HNSCC) Methods We obtained RNA-seq data for a cohort of patients with HNSCC from Gene Expression Omnibus (GEO) The Cancer Genome Atlas (TCGA) databases purpose analysis. levels were compared paracancerous tissue assess their differences. Transwell invasion assay flow cytometry used detect cellular apoptosis following siRNA-mediated...
Abstract Background Cancer-associated fibroblasts (CAF) play a critical role in promoting tumor growth, metastasis, and immune evasion. While numerous studies have investigated CAF, there remains paucity of research on their clinical application colorectal cancer (CRC). Methods In this study, we collected differentially expressed genes between CAF normal (NF) from previous CRC studies, utilized machine learning analysis to differentiate two distinct subtypes CRC. To enable practical...
To investigate the effects of aumolertinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), on biological behaviors neuroblastoma SH-SY5Y cells.CCK-8 assay, colony-forming Transwell assay and flow cytometry were used to assess 2, 4 8 μmol/L aumolertinib proliferation, survival, migration, invasion apoptosis cells, changes in ultrastructure cells observed using transmission electron microscopy. The protein expressions Bax, Bcl-2, E-cadherin, vimentin, MMP2, MMP9...