A5027686615- Ultrasound and Hyperthermia Applications
- Cell death mechanisms and regulation
- Ultrasound and Cavitation Phenomena
- Advanced Numerical Methods in Computational Mathematics
- Cancer-related Molecular Pathways
- Heat shock proteins research
- Numerical methods in engineering
- Electron Spin Resonance Studies
- Effects of Radiation Exposure
- Microbial Inactivation Methods
- RNA Interference and Gene Delivery
- Plasma Applications and Diagnostics
- Heme Oxygenase-1 and Carbon Monoxide
- Bioactive Compounds and Antitumor Agents
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Electromagnetic Simulation and Numerical Methods
- Endoplasmic Reticulum Stress and Disease
- Redox biology and oxidative stress
- Mathematical Dynamics and Fractals
- Neuroscience and Neuropharmacology Research
- PARP inhibition in cancer therapy
- Cancer therapeutics and mechanisms
- Cancer Cells and Metastasis
- Fractional Differential Equations Solutions
Shandong Jianzhu University
2012-2025
University of Toyama
2015-2024
Lanzhou Jiaotong University
2024
Shandong Provincial QianFoShan Hospital
2014-2023
Shandong First Medical University
2022-2023
Shandong University
2007-2022
Shanxi Medical University
2022
Second Hospital of Shanxi Medical University
2022
People's Liberation Army 401 Hospital
2020
Tianjin Medical University
2016-2018
Abstract Gold nanoparticles (Au-NPs) have attracted attention as a promising sensitizer owing to their high atomic number (Z), and because they are considered fully multifunctional, preferred over other metal nanoparticles. Cold atmospheric plasma (CAP) has also recently gained attention, especially for cancer treatment, by inducing apoptosis through the formation of reactive oxygen species (ROS). In this study, activity different sized Au-NPs with helium-based CAP (He-CAP) was analyzed,...
Insulin resistance contributes to several disorders including type 2 diabetes and cardiovascular diseases. Carpachromene is a natural active compound that inhibits α-glucosidase enzyme. The aim of the present study investigate potential activity carpachromene on glucose consumption, metabolism insulin signalling in HepG2 cells resistant model. A cell model (HepG2/IRM) was established. Cell viability assay HepG2/IRM performed after carpachromene/metformin treatment. Glucose concentration...
Abstract The neuroprotective effects of platelet‐derived growth factor (PDGF) and the major signaling pathways involved in these were examined using primary cultured mouse cortical neurons subjected to H 2 O ‐induced oxidative stress. specific function PDGF β‐receptor (PDGFR‐β) was by selective deletion corresponding gene Cre‐loxP system vitro. In wild‐type neurons, PDGF‐BB enhanced survival suppressed caspase‐3 activation. prosurvival effect PDGF‐AA less than that PDGF‐BB. highly activated...
The effect of resveratrol on various human cancer cells was investigated with special focus apoptotic cell death, in an attempt to further characterize its mechanism action. There were great differences the anti-viability between different types cells. While inhibition viability by marked U937 and MOLT-4 leukemia cells, moderately inhibited MCF-7 breast, HepG2 liver, A549 lung slight Caco-2, HCT116, SW480 colon Following treatment, markedly increased population late but underwent apoptosis...
Electron paramagnetic resonance (EPR)-spin trapping and flow cytometry were used to identify free radicals generated using argon-cold atmospheric plasma (Ar-CAP) in aqueous solutions intracellularly comparison with those by X-irradiation. Ar-CAP was a high-voltage power supply unit low-frequency excitation. The characteristics of estimated vacuum UV absorption emission spectra measurements. Hydroxyl (·OH) hydrogen (H) atoms identified the spin traps 5,5-dimethyl-1-pyrroline N-oxide (DMPO),...
Metastatic breast cancer is an incurable form of that exhibits high levels epithelial-mesenchymal transition (EMT) markers. Angiotensin II has been linked to various signaling pathways involved in tumor cell growth and metastasis. The aim this study investigate, for the first time, anti-proliferative activity azilsartan, angiotensin receptor blocker, against lines MCF-7 MDA-MB-231 at molecular level. Cell viability, cycle, apoptosis, colony formation, migration assays were performed. RT-PCR...
Idiopathic pulmonary fibrosis is a progressive, irreversible lung disease that leads to respiratory failure and death. Vincamine an indole alkaloid obtained from the leaves of Vinca minor acts as vasodilator. The present study aims investigate protective activity vincamine against EMT in bleomycin (BLM)-induced via assessing apoptotic TGF-β1/p38 MAPK/ERK1/2 signaling pathways. In bronchoalveolar lavage fluid, protein content, total cell count, LDH were evaluated. N-cadherin, fibronectin,...
Please cite this paper as: Protective effects of platinum nanoparticles against UV‐light‐induced epidermal inflammation. Experimental Dermatology 2010; 19 : 1000–1006. Abstract: Intracellular reactive oxygen species (ROS) and apoptosis play important roles in the ultraviolet (UV)‐induced inflammatory responses skin. Metal have been developed to increase catalytic activity metals, which is because large surface area smaller particles. Platinum (nano‐Pt) protected by poly acrylic acid were...
Platinum nanoparticles (Pt-NPs) are known to possess anti-tumouric activity and the ability scavenge superoxides peroxides indicating that they can act as superoxide dismutase (SOD)/catalase mimetics. These potentials seem useful in protection and/or amelioration of oxidative stress-associated pathologies, but, when combined with a therapeutic modality depends upon mediation reactive oxygen species cell killing induction, effect Pt-NPs might be questionable. Here, effects polyacrylic...
Fluoroquinolones (FQs) are synthetic broad-spectrum antimicrobial agents that have been recently repurposed to anticancer candidates. Designing new derivatives of FQs with different moieties target DNA topoisomerases could improve their efficacy. The present study aimed synthesize a novel ciprofloxacin derivative, examine its activity against HepG2 and A549 cancer cells, investigate the possible molecular mechanism underlying this by examining ability inhibit topo I/II induce apoptotic...
AbstractPurpose : To investigate the mechanisms and pathways of X-ray apoptosis in Molt-4 cells, focusing on mitochondrial cytosolic Ca2+ ([Ca2+]i) regulation. Materials methods X-irradiated cells cell extract (CE) were used to analyse: (1) induced (Giemsa stain), (2) p53, Bcl-2 Bax expressions (immunoblot), (3) potential Deltapsi (4) [Ca2+]i (flow cytometry), (5) caspasem 3 activity, (6) roles [Ca2+]- caspase-3-mediated by inhibiting either or both for apoptosis. Results sensitive since 5Gy...
The N-myc downstream-regulated gene 2 (NDRG2) is involved in tumor cell differentiation and apoptosis, but its function angiogenesis remains to be established. Here, we employed adenovirus overexpressing NDRG2 (Ad-NDRG2) efficiently up-regulate target expression the NDRG2-low-expressing, breast cancer line MCF-7. Moreover, VEGF secretion was decreased MCF-7 cells infected by Ad-NDRG2, medium conditioned these could significantly inhibit proliferation, tube formation invasion of human...
There are intensive debates about the effects and mechanisms of radiofrequency (RF) hyperthermia in oncology. We theoretically modelled mechanism nanoheating effect RF current at cellular subcellular level. Then, we experimentally investigated heating comparison with selective modulated electrohyperthermia water-bath conventional (WHT) using U937 suspension cell line model. The two heating-processes resulted different distributions energy-absorption, causing thermal processes. Both (fit to...