A5016654061- Birth, Development, and Health
- Maternal Mental Health During Pregnancy and Postpartum
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Air Quality and Health Impacts
- Child Nutrition and Feeding Issues
- Breastfeeding Practices and Influences
- Fatty Acid Research and Health
- Obesity, Physical Activity, Diet
- Asthma and respiratory diseases
- Pregnancy and Medication Impact
- Neonatal Respiratory Health Research
- Maternal and Perinatal Health Interventions
- Child and Adolescent Psychosocial and Emotional Development
- Heavy Metal Exposure and Toxicity
- Diet and metabolism studies
- Nutritional Studies and Diet
- Vitamin D Research Studies
- Infant Development and Preterm Care
- Climate Change and Health Impacts
- Lipoproteins and Cardiovascular Health
- Adipose Tissue and Metabolism
- Allergic Rhinitis and Sensitization
- Infant Health and Development
- Effects and risks of endocrine disrupting chemicals
University of Toyama
2016-2025
Hyogo University
2024
National Institute for Environmental Studies
2021-2024
Kumamoto University
2024
Chiba University
1990-2021
East Asia School of Theology
2021
Tokyo Medical and Dental University
2021
Chubu University
2021
Nagoya University
2021
Japan Science and Technology Agency
2001-2003
Fatty acids and thiazolidinediones act as potent activators of the adipose differentiation program in established preadipose cell lines. In this report, effects these agents on pathway myoblasts have been investigated. Exposure C2C12N (a subclone C2C12 line) to or fatty prevents expression myogenin, α-actin, creatine kinase, thus abolishing formation multinucleated myotubes. These treatments lead parallel a typical including acquisition adipocyte morphology activation adipose-related genes....
Abstract Background Lower socioeconomic status is often thought to be associated with an elevated risk of postpartum depression; however, this relationship exhibits noticeable heterogeneity between studies. The present study examined in Japan. Methods Data were obtained from 90,194 mothers ongoing birth cohort the Japan Environment and Children’s Study. Socioeconomic was assessed based on mothers’ highest education level during pregnancy. Postpartum depression identified at 1 6 months...
Capturing epidemiological signatures is essential to document burdens of disease and design health care services, including prevention measures, clinical interventions, policies. There are large geographical ethnic variations in the epidemiology allergic immunological diseases. Various data available from North America Europe, but diseases Asia not well documented.
The pathogenesis of severe pulmonary hypertension seems to be related inflammatory response in diseased sites. Monocyte chemoattractant protein-1 (MCP-1) has been reported play a role the development congestive heart failure. In this immunological response, activation and migration leukocytes including macrophages region are important factors. We hypothesized that severity may MCP-1, which is thought upregulated by blood pressure or shear stress vasculature as well reactions chronic...
Postpartum depression is a major mental health issue. It not only adversely affects the mother's quality of life, but also mother-infant bonding. However, relationship between postpartum (at multiple points after childbirth) and bonding failure one year birth well understood. This study investigates at 1-month 6-month 1 with large cohort.Data from 83 109 mothers Japan Environment Children's Study were analyzed. Mother-infant 1-year delivery was assessed using Mother-to-Infant Bonding Scale...
This research aimed to examine the efficacy of early initiation breastfeeding within 1 h birth, skin-to-skin contact, and rooming-in for continuation exclusive until 6 months postpartum. The used data from Japan Environment Children's Study (JECS), a nationwide government-funded birth cohort study. A total 80,491 mothers in between January 2011 March 2014 who succeeded or failed exclusively breastfeed were surveyed JECS. Multiple logistic regression model was analyse data. percentage is...
The extremes of maternal pre-pregnancy body mass index (BMI) are known to be risk factors associated with obstetric and adverse perinatal outcomes. Among Japanese women aged 20 years or older, the prevalence underweight (BMI < 18.5 kg/m2) was 11.5% in 2019. Maternal thinness is a health problem caused by desire become slim. This study aimed investigate association between severity low BMI outcomes, including preterm birth (PTB), weight (LBW), small-for-gestational age (SGA).We conducted...
It is unclear whether increased television (TV) and DVD viewing in early childhood from age 1 year decreases development or poor increases TV/DVD viewing.
Abstract The association between maternal pre-pregnancy smoking status and asthma risk is unclear. This study aimed to investigate the pre- post-pregnancy bronchial at 3 years of age in a large birth cohort. Data 75,411 mother–child pairs from Japan Environment Children's Study (JECS) were analysed using multivariate logistic regression analysis. Overall, 7.2% children had asthma. before childbirth was as follows: Never = 60.0%, Quit recognising current pregnancy 24.1%, after finding out...
Monocyte chemoattractant protein-1 (MCP-1) is a member of chemokines with activity for monocytes, T cells, mast and basophils. Precursor mRNA or protein was detected at high levels in the lesions several diseases, such as pulmonary fibrosis, rheumatoid arthritis, atherosclerosis, some types tumors. The regulation MCP-1 production role this chemokine pathophysiologic states, however, remain largely unknown. In study, using an enzyme-linked immunosorbent assay (ELISA), we measured circulating...
Accumulating data suggest that endocrine disruptors affect not only the reproductive system, but also immune system. We demonstrate here including diethylstilbestrol (DES) and bisphenol-A (BPA) enhance autoantibody production by B1 cells both in vitro vivo. BWF1 mice, a murine model for systemic lupus erythematosus (SLE), implanted with Silastic tubes containing DES after orchidectomy developed characterized immunoglobulin G (IgG) anti-DNA antibody IgG deposition glomeruli kidney as well...
Background The aim of this study was to examine how physical activity (PA) before and during pregnancy influences outcomes, particularly preterm delivery mode delivery. Methods This based on the Japan Environment Children's Study. A total 92,796 pregnant women who gave birth live singleton babies were included. Information mean PA per week extracted from responses questionnaires completed by second third trimesters pregnancy. obtained answered recall at participation. level stratified into...
Recent research suggests that melatonin (Mel), an endogenous hormone and natural supplement, possesses anti-proliferative effects can sensitise cells to anti-cancer therapies. Although shikonin (SHK) also potential properties, the poor solubility severe systemic toxicity of this compound hinders its clinical usage. In study, we combined Mel SHK, a potentially promising chemotherapeutic drug combination, with aim reducing SHK enhancing overall effects. We demonstrate for first time...
The results of several epidemiological studies have shown a moderate association between postpartum depression (PPD) and mother-infant bonding (MIB); however, associations changes that longitudinally considered parity were not reported. We investigated the possible PPD MIB at one month after birth, in addition, these indices by parity. From dataset comprising 103,099 maternal registrations Japan Environment Children's Study, present study analyzed complete data on questionnaires for 76,363...
In 1952, the Japanese Society for Hygiene had once passed a resolution at its 22nd symposium on population control, recommending suppression of growth based idea cultivating healthier in area eugenics. Over half century has now since this recommendation; Japan is witnessing an aging (it estimated that over 65-year-olds made up 27.7% 2017) and decline birth rate (total fertility 1.43 births per woman unparalleled world; faced with "super-aging" society low rate. 2017, to encourage all...