A5020342259- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Respiratory viral infections research
- Birth, Development, and Health
- Immunodeficiency and Autoimmune Disorders
- Vitamin D Research Studies
- Dermatology and Skin Diseases
- Pregnancy and Medication Impact
- Vaccine Coverage and Hesitancy
- Gestational Diabetes Research and Management
- Breastfeeding Practices and Influences
- Pregnancy and preeclampsia studies
- Maternal Mental Health During Pregnancy and Postpartum
- Vitamin C and Antioxidants Research
- Eosinophilic Esophagitis
- Nutritional Studies and Diet
- Neonatal Respiratory Health Research
- Reproductive System and Pregnancy
- Climate Change and Health Impacts
- Effects and risks of endocrine disrupting chemicals
- Thyroid Disorders and Treatments
- Iron Metabolism and Disorders
- Urticaria and Related Conditions
- Heart Rate Variability and Autonomic Control
National Center For Child Health and Development
2019-2024
University of Fukui
2017
Capturing epidemiological signatures is essential to document burdens of disease and design health care services, including prevention measures, clinical interventions, policies. There are large geographical ethnic variations in the epidemiology allergic immunological diseases. Various data available from North America Europe, but diseases Asia not well documented.
Oxytocin (OT) signalling represents one of the most critical systems involved in human social behaviour. Although several studies have examined relationship between functioning and peripheral OT levels, association development attention has not been well studied. Therefore, we investigated developmental gaze fixation for cues levels during young childhood. We visual using an eye tracking system infants children (5-90 months age) measured concentration saliva samples. observed a negative age...
Skin inflammation leads to altered cytokine/chemokine production and causes systemic inflammation. The mechanism of atopic dermatitis (AD) is recognized affect metabolism. This study aimed examine the relationship between early-onset persistent eczema body weight, height, mass index (BMI), in addition food allergy a birth cohort among infants. design was nationwide, multicenter, prospective study—the Japan Environment Children’s Study (JECS). Generalized linear models were fitted for z...
Understanding the influence of both genetics and environment on human health, especially early in life, is essential for shaping long-term health. Here, we utilize a nationwide prospective birth cohort, Japan Environment Children's Study (JECS), to conduct large-scale population-based genetic study using biannual questionnaire surveys biological physical measurements collected from parents their children since participant mothers were pregnant. Analyses genome-wide genotyping 80,638 child...
The influence of family allergic history on food allergy in offspring Japan is unknown. We analyzed data from a nationwide birth cohort study using logistic regression models to examine the associations maternal, paternal, and both parental histories diseases (food allergy, atopic dermatitis, asthma, rhinitis) with their child’s at 1.5 3 years age. This analysis included 69,379 singleton full-term mothers 37,179 fathers children. All showed significant positive allergy. When parents had...
Previous epidemiological studies have reported an increased risk of anemia in people with allergic disorders. However, previous followed a cross-sectional design. The aim this study was to investigate the association between two conditions cohort dataset. We used data 80,943 children Japan Environment and Children’s Study, largest birth Japan. disorders evaluated logistic regression model propensity score analysis. After adjusting for potential confounders, asthma (odds ratio [OR], 1.85; 95%...
Abstract Background Food allergy children and their families tend to have emotional distress anxiety. There been few reports of differences in parenting stress a child's food phenotypes. Methods We examined the associations between phenotypes assessed by Parenting Stress Index‐Short Form (PSI‐SF) from national birth cohort (Japan Environment Children's Study). Results included 65,805 for statistical analysis. Of them, 7.2% had diagnosis at 2 years old. The means total PSI‐SF (39.9 ± 10.3,...
Abstract Background Adjuvants used in inactivated vaccines often upregulate type 2 immunity, which is dominant allergic diseases. We hypothesised that cumulative adjuvant exposure infancy may influence the development of allergies later life by changing balance 1/type immunity. examined relationship between immunisation with different vaccine types and disease development. Methods obtained information regarding vaccinations diseases through questionnaires were The Japan Environment...
Abstract Aims/Introduction We aimed to evaluate the metabolic status of pregnant women by assessing biomarkers participants in Japan Environment and Children’s Study, a nationwide, multicenter, pregnancy birth cohort. Materials Methods Pregnant aged 14–50 years were studied 15 centers across Japan. Clinical information was obtained using self‐administered questionnaires. Blood samples taken during first two trimesters measure biomarkers. Samples divided into seven groups according weeks...
Tobacco smoke exposure is known to lower serum 25-hydroxyvitamin D (25(OH)D) concentrations. This study evaluated the association between passive smoking and vitamin deficiency (VDD) in young children using data from Japan Environment Children’s Study (JECS), largest birth cohort Japan. Information on parental status was extracted a survey of JECS for aged 1.5 years 25(OH)D concentrations were obtained blood tests Sub-Cohort performed at age 2 years. Logistic regression linear models fitted...
Maternal dietary zinc intake and childhood allergy have inconsistent relationships. Thus, this study aimed to evaluate the influence of low maternal during pregnancy on developing pediatric allergic diseases. This was designed using Japan Environment Children’s Study dataset. The model building used data from 74,948 mother–child pairs. estimated based food frequency questionnaire, collecting information 171 beverage items. Fitted logistic regression models generalized estimating equation...
The association between maternal diet during pregnancy and allergy in offspring remains contentious. Here, we examined the intake of vegetables related nutrients allergic diseases at one year age. A cohort 80,270 pregnant women enrolled Japan Environment Children’s Study were asked to respond a food frequency questionnaire International Asthma Allergies Childhood postpartum. categorized into quintiles according energy-adjusted nutrients. Using categorizations as exposure variables, adjusted...
Few epidemiologic studies have examined the role of maternal iron status in allergic diseases offspring and findings been inconsistent. We used a large birth cohort Japan to explore association markers for (maternal hemoglobin, hematocrit dietary intake during pregnancy) with allergy development early childhood. analyzed information on children age 0–3 years from Environment Children’s Study (JECS). logistic models generalized estimating equation evaluate effect hemoglobin levels allergies...
Abstract Background The study aim was to obtain epidemiological data on vitamin D levels for the pediatric population in Japan. We assessed prevalence of deficiency and insufficiency 2-year-old Japanese children using from a large ongoing birth cohort study. Methods Data analysis obtained Japan Environment Children’s Study (JECS) Sub-Cohort (SCS) JECS. evaluated children’s serum 25(OH) by 5th, 10th, 25th, 50th, 75th, 90th, 95th percentiles, rates or insufficiency. also presented weighted...
Previous studies have reported that maternal asthma increases the risk of preterm birth. We hypothesized inflammatory reactions caused by allergic diseases might affect uterine environment and, subsequently, perinatal outcomes. The objective this study was to examine associations between features among mothers and pregnancy outcomes in a nationwide birth cohort.We analyzed data from pregnant women obtained Japanese Environment Children's Study (JECS), general cohort study. used binomial...
Vitamin D (VitD) may affect immune system modulation and result in the development of atopic dermatitis (AD). However, published findings have remained controversial. We investigated association between early-life 25-hydroxyvitamin (25(OH)D) levels AD risk at childhood with a birth cohort. The data were obtained from "the Japan Environment Children's Study (JECS)" Sub-Cohort study JECS" performed children aged 2 years. "Liquid chromatography-tandem mass spectrometry" was used to measure...
Physical examinations to assess pubertal development are challenging in large epidemiological surveys. This study aimed the reliability of judgment onset Japanese children by original self-assessment sheet.A total 144 aged 10 or 12 years were recruited between March 2019 and September 2020 from pediatric endocrine outpatient clinics participating institutions. Agreement physician- participantassessed onsets was determined using unweighted kappa (UK) Gwet's agreement coefficient (AC1).The...
Hypertensive disorders of pregnancy (HDP) are one the most common medical conditions that women encounter during pregnancy. Whether or not hypertensive associated with allergic in offspring is unclear. This study used data from a large Japanese birth cohort to investigate whether HDP contributes development at 3 years. We also assessed effect blood pressure different trimesters on children's allergies.We obtained Japan Environment and Children's Study (JECS), which included 104 062 fetal...
Although endotoxin concentration in the environment is negatively associated with atopic dermatitis (AD) onset early childhood, association between and eczema resolution children preexisting unclear. The aim of this study was to evaluate house dust persistence young children. authors used data from participating JECS (Japan Environment Children's Study). In who had AD or AD-like lesions at age 1 year, investigated prevalence 3 years (categorized by quartiles) on children's mattresses ages...
The most common hormonal and metabolic disease in early childhood is congenital hypothyroidism (CH). This study aimed to describe CH large-scale birth cohort data summarize the results of serum thyroid-stimulating hormone (TSH) free thyroxine (fT4) levels 2-yr-old children. Data were obtained from Japan Environment Children's Study (JECS), we identified 171 children with detected newborn screenings or medical records (170.5 per 100,000 population). Infants are at higher risk developing...
Abstract Background Numerous studies suggest that sex steroids might play a role in disparity observed allergic diseases adults. However, whether hormones influence children remains unclear. The aim of the present study was to examine association steroid with disease Japanese children. Methods cross-sectional included 145 6-year-old participating pilot birth cohort Japan Environment and Children’s Study. Data on were obtained from questionnaires, serum levels allergen-specific IgE measured....
Changes in household endotoxin concentration may affect the prognosis of food allergy (FA), but data on association between and an already-developed FA are scarce. Thus, we investigated environmental exposure tolerance to hen’s egg (HE) cow’s milk (CM) using from children participating Japan Environment Children’s Study who had HE allergies (n = 204) CM 72) their first year life. We grouped results into quartiles 1–4 (Q1–Q4). In with allergy, there was no significant difference prevalence at...
Pre-pregnancy weight status is related to offspring health and may influence dietary patterns during pregnancy. We aimed evaluate the link between pre-pregnancy pregnancy.Dietary data were collected using a FFQ middle or late Dietary identified principal component analysis. Anthropometric extracted from medical charts. Multiple linear regression was used assess associations (severely moderately underweight, mildly normal weight, overweight obese) pregnancy after adjusting for...