A5072499747- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Herpesvirus Infections and Treatments
- Hepatitis C virus research
- Respiratory viral infections research
- Hepatitis B Virus Studies
- Influenza Virus Research Studies
- Cytomegalovirus and herpesvirus research
- Animal Disease Management and Epidemiology
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Immunodeficiency and Autoimmune Disorders
- T-cell and Retrovirus Studies
- Immune Cell Function and Interaction
- Child Nutrition and Feeding Issues
- Gestational Diabetes Research and Management
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Toxin Mechanisms and Immunotoxins
- Click Chemistry and Applications
- HIV-related health complications and treatments
- Diabetes Management and Education
- Poxvirus research and outbreaks
- Monoclonal and Polyclonal Antibodies Research
Tottori University Hospital
2023-2025
Tottori University
2011-2024
Hyogo University
2024
Kumamoto University
2024
Tottori Prefectural Museum
2013-2021
Nishikawa Hospital
2017
University of Toyama
2007-2011
Kanazawa University
2004-2010
Japan International Cooperation Agency
2001-2004
Tohoku Medical and Pharmaceutical University
1996-2003
It is unclear whether increased television (TV) and DVD viewing in early childhood from age 1 year decreases development or poor increases TV/DVD viewing.
Transition state mimetic tripeptide human immunodeficiency virus (HIV) protease inhibitors containing allophenylnorstatine [(2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid] were synthesized and tested for activity against HIV in vitro. Two compounds, KNI-227 KNI-272, which highly potent with little inhibition of other aspartic proteases, showed the most infectivity cytopathic effect a wide spectrum strains. As target CD4+ ATH8 cells, 50% inhibitory concentrations type 1 LAI (HIV-1LAI),...
The prevalence study and the characterization of hepatitis C virus (HCV) was carried out in Philippines sequence determination 5′-untranslated region (5′-UTR)-Core NS5B regions HCV this study. An strain (SE-03-07-1689) collected Metro Manila, Philippines, belonged to discordant subtypes, 2b 1b 5′-UTR-Core regions, respectively. 9.3 kb including entire open reading frame compared with those reference strains retrieved from sequences database (GenBank/EMBL/DDBJ) indicated a recombination...
Introduction: This study was conducted to determine the current molecular prevalence of human immunodeficiency virus (HIV), hepatitis B (HBV), C (HCV), D (HDV), and T lymphotropic virus-1/2 (HTLV-1/2) circulating among drug abuser inmates incarcerated in prisons located Central Java, Indonesia. Methodology: Socio-epidemiological data blood specimens were collected from 375 four prisons. The samples analyzed with serological testing for HIV, HBV, HCV, HDV, HTLV-1/2. Results: seroprevalence...
Understanding the influence of both genetics and environment on human health, especially early in life, is essential for shaping long-term health. Here, we utilize a nationwide prospective birth cohort, Japan Environment Children's Study (JECS), to conduct large-scale population-based genetic study using biannual questionnaire surveys biological physical measurements collected from parents their children since participant mothers were pregnant. Analyses genome-wide genotyping 80,638 child...
Previous studies have demonstrated that paternal involvement in childcare for infants up to 6 months of age can prevent injuries children 18 age. However, the relationship after has not been clearly established. Therefore, this study investigated association between at and birth 4 years This analysed data from 72,343 mothers who participated Japan Environment Children's Study (JECS). Seven items age—indoor play, outdoor feeding child, diaper changing, dressing, bathing, putting child...
Functional constipation is the most common gastrointestinal disorder during childhood. Oral stimulation (mastication and toothbrushing) reportedly improves bowel movements, but association between daily toothbrushing behavior functional remains unknown. Data (n = 83,660) from fetal records 104,059) in Japan Environment Children's Study, an ongoing prospective birth cohort, were analyzed to investigate impact of frequency on childhood, using ROME III diagnostic criteria. After multiple...
Abstract Few studies have evaluated the association between duration of mothers’ digital media use (including mobile phones, tablets, and PCs) while with their children children’s development. Using data from Japan Environment Children’s Study, we explored this relationship through multiple regression analysis. Self-administered questionnaires measured use. Developmental outcomes were assessed using Kyoto Scale Psychological Development 2001 (KSPD), administered to two-year-olds by trained...
The relationship of pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) with continued breastfeeding (BF) in Japanese women remains unclear. To evaluate different maternal BMI GWG categories according to the initial BMI, we conducted an analysis BF until 6 months postpartum a large cohort. This study used data from Japan Environment Children's Study, which included approximately 100,000 pregnant women. Pre-pregnancy (kg/m2) was categorized as underweight (BMI < 18.5),...
We established a method to estimate the amounts of HIV-1 particles in plasma from patients with infection by using polymerase chain reaction (PCR) following reverse transcription (RT) viral RNA (RNA-PCR) and assessed potential usefulness this approach monitor changes load AIDS or AIDS-related complex (ARC) receiving 2′,3′-dideoxyinosine (ddI). Plasma samples were obtained 77 (49 AIDS/ARC 28 asymptomatic seropositives). Following ultracentrifugation plasma, was extracted pelleted virus...
KNI-272 represents a peptide-based protease inhibitor having potent antiretroviral activity against human immunodeficiency virus (HIV) in vitro. The structure contains allophenylnorstatine [(2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid] with hydroxymethylcarbonyl isostere. We asked whether this experimental anti-HIV agent could exert its vitro the presence of relatively high concentrations fetal calf serum (FCS) and assessed protein-binding properties by using fresh plasma preparations. 50...
Objectives Septic shock and sequential multiple organ failure remain the cause of death in septic patients. Vascular endothelial cell apoptosis may play a role pathogenesis syndrome. Caspase-8 is presumed to be apex receptor-mediated pathway, whereas caspase-3 belongs "effector" protease cascade. Synthetic small interfering RNAs (siRNAs) specifically suppress gene expression by RNA interference. Therefore, we evaluated therapeutic efficacy caspase-8/caspase-3 siRNAs murine model...
N-3 polyunsaturated fatty acids (PUFAs) have anti-inflammatory properties and are expected to prevent the onset of allergies. However, epidemiological studies investigating relationship between child allergies maternal intake n-3 PUFAs or fish yielded inconsistent results. Following exclusions from a dataset comprising 103,057 records Japan Environment Children's Study, 72,105 participants were divided into five groups according mothers' during pregnancy assess risk their children being...
Abstract Purpose The effects of general anesthesia on neurodevelopment in children remain controversial. We explored the relationship between and participating Japan Environment Children’s Study (JECS). Methods This study enrolled born 37 41 weeks pregnancy via single-vaginal delivery to pregnant women registered JECS January 2011 March 2014. Data were collected from mother-completed questionnaires medical transcripts. Neurodevelopment five domains was assessed every 6 months 12 48 age,...
C2 symmetry-based human immunodeficiency virus (HIV) protease inhibitors were examined in vitro as single agents or combination with 3'-azido-2',3'-dideoxythymidine (AZT) 2',3'-dideoxyinosine for activity against HIV type 1 (HIV-1). Ten pseudo-C2 active a laboratory strain (HIV-1IIIB) the HIV-1 cytopathic effect inhibition assay. Three inhibitors, A75925, A76928, and A77003, selected to represent range of aqueous solubility antiviral activity, four different strains tested. These three...
The relationships between host immune factors and HIV-1 disease progression are still in dispute. Unlike CCR5Delta32, which has been found to delay of HIV-1, there remain several whose effect on the clinical course is unconfirmed. To clarify relationships, we selected seven single-nucleotide polymorphisms (SNPs) out previously reported factors, namely, RANTES promoter -28G/-403A, In1.1C, SDF-1 3'A, IL-4 -589T, DC-SIGN -139C/-336C, examined these Japanese HIV-1-infected hemophiliacs (n =...
<b><i>Objective:</i></b> To define the molecular epidemiology of respiratory viral infections in adult patients. <b><i>Methods:</i></b> Nasal and throat swabs were collected from all patients with influenza-like illness (ILI), acute infection (ARI), or severe ARI (SARI) admitted to a tertiary hospital Surakarta, Indonesia, between March 2010 April 2011 analyzed for 19 viruses torque teno virus (TTV) human gyrovirus (HGyV)....
2',3'-Dideoxyadenosine (ddAdo) and its deamination product 2',3'-dideoxyinosine (ddIno) (didanosine) inhibit the replication infectivity of human immunodeficiency virus (HIV) in a number vitro assay systems. Early clinical studies (phase I) have indicated role for ddIno treatment patients with severe HIV infection. In present study, formation T cells (MOLT-4, ATH8, CCRF-CEM) pharmacologically active metabolite ddAdo, 2',3'-dideoxyadenosine-5'-triphosphate (ddATP), was found to be stimulated...
Abstract An experimental study on the absorption of low concentration sulfur dioxide into limestone slurries in a stirred tank reactor has been performed. The rates under various conditions were measured and processes have discussed. analysis data shows that dissolution process seems to play very important role absorption.
We evaluated the prevalence and profile of antiretroviral treatment (ART)-associated resistance mutations among HIV-1 strains in northern Vietnam by genotypically analyzing isolated from ART-naive individuals Hai Phong, a city which is highly prevalent. Plasma samples were collected injecting drug users (IDU, n = 760), female sex workers (FSW, 91), seafarers (n 94), pregnant women 200), blood donors 210), screened for antibodies. viral RNA was extracted HIV-1-positive samples, amplified...
Abstract In order to prevent cervical cancer, vaccines against human papilloma virus types 16 (HPV‐16) and 18 (HPV‐18) have been implemented worldwide. However, the HPV that cause cancer can differ according geographical area ethnicity. this new era of vaccine, it is important elucidate prevalent in each area. Therefore, prevalence infection abnormalities among 369 female commercial sex workers Philippines were examined. L1 gene was amplified by polymerase chain reaction (PCR) using modified...