A5028146410- Exercise and Physiological Responses
- Sports injuries and prevention
- Physical Activity and Health
- Muscle Physiology and Disorders
- Cardiovascular and exercise physiology
- Balance, Gait, and Falls Prevention
- Adipokines, Inflammation, and Metabolic Diseases
- Nutrition and Health in Aging
- Muscle metabolism and nutrition
- Respiratory viral infections research
- Sports Performance and Training
- Musculoskeletal pain and rehabilitation
- Obesity, Physical Activity, Diet
- Muscle activation and electromyography studies
- Ubiquitin and proteasome pathways
- Nutritional Studies and Diet
- Immune Cell Function and Interaction
- Adipose Tissue and Metabolism
- Context-Aware Activity Recognition Systems
- Asthma and respiratory diseases
- Quantum Chromodynamics and Particle Interactions
- Body Composition Measurement Techniques
- Particle physics theoretical and experimental studies
- Heart Rate Variability and Autonomic Control
- Motor Control and Adaptation
Tohoku University
2016-2025
The University of Tokyo
2009-2024
Tokyo Medical and Dental University
2024
Osaka University
2019-2022
San Antonio College
2018
University of Coimbra
2018
Waseda University
2006-2016
Tokyo Gas (Japan)
2016
University of South Carolina
2016
Tianjin Medical University
2015
We evaluated the association of nocturia with fracture and death in a large, community based sample Japanese individuals 70 years old or older.The baseline this population study was determined 2003 by an extensive health interview each participant. In we followed 784 mean ± SD age 76.0 4.6 (range to 97). Information on mortality during period provided National Health Insurance system details fractures were collected from medical records. compared risk bone without multivariate Cox...
Many issues prevent elderly individuals from exercising in daily life. There is a need for system that allows to engage exercise regularly at low cost. We developed an exergame uses Kinect(®) sensor (Microsoft Corp., Redmond, WA) and conducted randomized controlled trial of the effects using this on muscle strength balance healthy individuals.We enrolled 57 randomly divided them into intervention group (n=29) control (n=28) table random numbers. All participants underwent gait analyses were...
Nrf2 (NF-E2-related factor 2) contributes to the maintenance of glucose homeostasis in vivo. suppresses blood levels by protecting pancreatic β cells from oxidative stress and improving peripheral tissue utilization. To elucidate molecular mechanisms which homeostasis, we generated skeletal muscle (SkM)-specific Keap1 knockout (Keap1MuKO) mice that express abundant their SkM then examined target gene expression tissue. In Keap1MuKO mice, were significantly downregulated glycogen branching...
Enveloped viruses have caused the majority of epidemics and pandemics over past decade. Direct sensing virus particles (virions) holds great potential for functional analysis enveloped viruses. Here, we explore a series viral membrane-targeting amphipathic helical (AH) peptide-based molecular probes assessment infectious titers human coronavirus 229E (HCoV-229E). The M2-protein-derived AH peptide is identified as strong binder HCoV-229E, its conjugate with Nile Red, M2-NR, exhibits...
Abstract The objective of the present study was to evaluate association between suicidal ideation and potentially related factors in an elderly urban Japanese population. This a community‐based, cross‐sectional study. Urban community residents aged 70 years or more were interviewed regarding sociodemographic health‐related variables. Subjects with depressive symptoms underwent further evaluation by psychiatrists using criteria Diagnostic Statistical Manual Mental Disorders, 4th edition....
Adult muscle stem cells (satellite cells) are required for adult skeletal regeneration. A proper balance between quiescence, proliferation, and differentiation is essential the maintenance of satellite cell pool their regenerative function. Although ubiquitin-proteasome most protein degradation in mammalian cells, how its dysfunction affects tissue remains unclear. Here, we investigated function proteasome using mice lacking crucial proteasomal component, Rpt3. Ablation Rpt3 decreased...
Interleukin (IL)-6 is locally produced in skeletal muscles and shows a remarkable increase plasma after eccentric exercises.To elucidate the cell types responsible for IL-6 production exercises.Controlled laboratory study.An contraction model was made using electrical stimulation. The authors investigated muscle damage regeneration processes exercises histologically, expressing its subcellular compartimentalization with time immunohistochemically exercises.Swollen myofibers were detected...
Human influenza viruses attach to sialic acid with an α2,6linkage (SAα2,6Gal) on the airway epithelial cells, and entry of into cells uncoating require low pH endosomes. Bafilomycin A<sub>1</sub>, a macrolide antibiotic specific inhibitor vacuolar H<sup>+</sup>-ATPase, inhibits growth type A B human in Madin-Darby canine kidney cells. However, inhibitory effects clinically used antibiotics virus infection airways have not been studied. To examine clarithromycin seasonal infection, cultured...
Inflammation has been strongly related to metabolic syndrome (MetS). Periodontal disease is the most common chronic infection in adults. We investigated a cross-sectional (n = 925) and 3-year longitudinal 685) relationship between daily frequency of toothbrushing MetS. In analysis, prevalence MetS was 15.7%. After adjustment for potential confounding factors (including all lifestyle factors), odds ratios (95% confidence interval [CI]) having those who brushed 2 times/day ≥ 3 were 0.71...
Aging is associated with decreased skeletal muscle function. Increased levels of advanced glycation end products (AGEs) in tissue are observed advancing age and diabetes. Although serum AGE level negatively grip strength elderly people, it unknown whether this association present adult males. To determine the relationship between accumulation power among Japanese men. Skin autofluorescence (AF) (a noninvasive method for measuring AGEs), (n = 232), leg extension 138) were measured men [median...
Abstract Background Uric acid (UA) may protect muscle function from oxidative damage due to reactive oxygen species through its powerful antioxidant capacity. However, several studies have demonstrated that hyperuricemia is closely related systemic inflammation and has oxidant properties effects, both of which increase the risk strength loss. The purpose this study was examine association serum UA concentration with grip leg extension power in adult men. Methods This a cross-sectional survey...
The ubiquitin-proteasome and autophagy-lysosome pathways are the two major routes of protein organelle clearance. role proteasome pathway in mammalian muscle has not been examined vivo. In this study, we report that muscle-specific deletion a crucial proteasomal gene, Rpt3 (also known as Psmc4), resulted profound growth defects decrease force production mice. Specifically, developing muscles conditional Rpt3-knockout animals showed dysregulated activity. autophagy was upregulated, but...
Abstract Exercise can alter the composition of gut microbiota. However, studies examining effects exercise on microbiota in elderly are lacking. This study aims to investigate whether an 8-week training affect physically inactive women. Fourteen women were randomly assigned either group or control group. Repeated-measures analysis variance was used reveal changes Alpha diversity did not change significantly. A tendency form 2 clusters observed for operational taxonomic units (OTU) after...
The differential cross sections of the Σ^{-}p→Λn reaction were measured accurately for Σ^{-} momentum (p_{Σ}) ranging from 470 to 650 MeV/c at J-PARC Hadron Experimental Facility. Precise angular information about was obtained first time by detecting approximately 100 events each step Δcosθ=0.1. show a slightly forward-peaking structure in regions. integrated -0.7≤cosθ≤1.0 as 22.5±0.68 [statistical error(stat.)] ±0.65 [systematic error(syst.)] mb and 15.8±0.83(stat)±0.52(syst)...
Preclinical studies reveal maternal exercise as a promising intervention to reduce the transmission of multigenerational metabolic dysfunction caused by obesity. The benefits on offspring health may arise from multiple factors and have recently been shown involve DNA demethylation critical hepatic genes leading enhanced glucose metabolism in offspring. Histone modification is another epigenetic regulator, yet effects obesity histone methylation are not known. Here, we find that high-fat diet...
Chronic inflammation induces lymphangiogenesis and blood vessel remodelling. Since aged pneumonia patients often have repeated episodes of aspiration pneumonia, the pathogenesis may involve chronic inflammation. For lymphangiogenesis, VEGFR-3 its ligand VEGF-C are key factors. No previous studies examined or vascular changes in mouse models. In lung inflammation, little is known about effect blocking on and, moreover, disease condition. This study aimed to establish a model examine presence...