A5036941473- Underwater Acoustics Research
- Asthma and respiratory diseases
- Lung Cancer Treatments and Mutations
- Underwater Vehicles and Communication Systems
- Ear Surgery and Otitis Media
- Immunotherapy and Immune Responses
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mycobacterium research and diagnosis
- Particle physics theoretical and experimental studies
- Ear and Head Tumors
- Cancer Immunotherapy and Biomarkers
- Acoustic Wave Phenomena Research
- Tuberculosis Research and Epidemiology
- High-Energy Particle Collisions Research
- Geophysical Methods and Applications
- Pneumonia and Respiratory Infections
- Radioactive element chemistry and processing
- Immune Cell Function and Interaction
- Ultrasonics and Acoustic Wave Propagation
- Lung Cancer Research Studies
- CAR-T cell therapy research
- Colorectal Cancer Treatments and Studies
- Antibiotic Resistance in Bacteria
- Advanced Fiber Optic Sensors
- Pediatric health and respiratory diseases
Niigata University
2016-2025
National Defense Academy of Japan
1996-2024
Niigata University Medical and Dental Hospital
2016-2024
Keio University
2024
Tohoku University
2013-2023
Ann Arbor Center for Independent Living
2022
University of Richmond
2022
Oregon Medical Research Center
2022
Lindsay Unified School District
2022
New York Proton Center
2022
A novel EGFR-tyrosine kinase inhibitor (TKI), osimertinib, has marked efficacy in patients with EGFR-mutated lung cancer. However, some show intrinsic resistance and an insufficient response to osimertinib. This study showed that osimertinib stimulated AXL by inhibiting a negative feedback loop. Activated was associated EGFR HER3 maintaining cell survival inducing the emergence of cells tolerant inhibition reduced viability cancer overexpressing were exposed The addition during either...
Abstract Inflammatory conditions are associated with tumor development. IL-1β is a multifunctional and proinflammatory cytokine that affects nearly all types of cells. To investigate the role in growth vivo, we transduced retroviral vector coding human gene into mouse Lewis lung carcinoma (LLC) cells subsequently inoculated transformant (LLC/IL-1β) to syngeneic C57BL/6 mice. Tumors derived from LLC/IL-1β grew faster (240%, day 18, vs null-vector control LLC/neo; p < 0.01) showed more...
MSCs are nonhematopoietic stem cells capable of differentiating into various mesoderm-type cells. have been considered to be a potential vehicle for cell-based gene therapy because relatively easily expanded in vitro and the propensity migrate proliferate tumor tissue after systemic administration. Here, we demonstrated tropism mouse multiple tissues lung i.v. injection green fluorescent protein-positive vivo. We transduced CX3CL1 (fractalkine), an immunostimulatory chemokine, ex vivo using...
Nephrotoxicity induced by antimicrobial or anticancer drugs is a serious clinical problem. Megalin, an endocytic receptor expressed at the apical membranes of proximal tubules, mediates nephrotoxicity aminoglycosides and colistin, key antimicrobials for multidrug-resistant organisms. The mechanisms underlying vancomycin, methicillin-resistant Staphylococcus aureus, cisplatin, important drug, are unknown, although these gentamicin, aminoglycoside, suppressed experimentally with cilastatin. In...
Current hypotheses suggest that aberrant wound healing has a critical role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). In these hypotheses, continuous TGF-β1 secretion by alveolar epithelial cells (AECs) abnormal promoting fibroblast differentiation into myofibroblasts. Mesenchymal stem (MSCs) home to injury site and reduce secreting multifunctional antifibrotic humoral factors IPF. this study, we show MSCs can correct inadequate-communication between mesenchymal through STC1...
Abstract Purpose: Currently, an optimal therapeutic strategy comprising molecularly targeted agents for treating EGFR-mutated non–small cell lung cancer (NSCLC) patients with acquired resistance to osimertinib is not available. Therefore, the initial intervention crucial prolonged survival of these patients. The activation anexelekto (AXL) signaling known be associated intrinsic and EGFR tyrosine kinase inhibitors (EGFR-TKIs). In this study, we investigated best combat AXL-induced tolerance...
Abstract Background Treatment with epidermal growth factor receptor (EGFR)‐tyrosine kinase inhibitors (TKIs) leads to initial response in most patients EGFR ‐mutated non‐small cell lung cancer (NSCLC). In contrast, little is known of the subpopulation NSCLC mutations who exhibit clinical outcomes that require treatment immune checkpoint (ICIs). Therefore, identify eligible cases treat ICIs, we retrospectively analyzed correlation between features and efficacy ICIs mutations. Patients Methods...
Secretory leukoprotease inhibitor (SLPI) protects tissue against the destructive action of neutrophil elastase at site inflammation. Recent studies on new functions SLPI have demonstrated that may play a larger role in innate immunity than merely as protease inhibitor. To clarify bacterial infections, we generated SLPI-deficient mice (SLPI(-/-) mice) and analyzed their response to experimental endotoxin shock induced by lipopolysaccharide (LPS). SLPI(-/-) showed higher mortality from did...
Previous studies have demonstrated that mesenchymal stromal cells (MSCs) enhance cell survival through upregulation and secretion of stanniocalcin-1 (STC1). This study shows MSC-derived STC1 promotes lung cancer by uncoupling oxidative phosphorylation, reducing intracellular reactive oxygen species (ROS), shifting metabolism towards a more glycolytic metabolic profile. upregulated protein 2 (UCP2) in injured A549 an STC1-dependent manner. Knockdown UCP2 reduced the ability MSCs recombinant...
The exceptional immunostimulatory capacity of DCs makes them potential targets for investigation cancer immunotherapeutics. We show here in mice that TNF-α–stimulated DC maturation was accompanied by increased expression OX40 ligand (OX40L), the lack which resulted an inability mature to generate cellular antitumor immunity. Furthermore, intratumoral administration modified express OX40L suppressed tumor growth through generation tumor-specific cytolytic T cell responses, were mediated CD4+...
Asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) was proposed by the science committees of both Global Initiative for Asthma (GINA) and Chronic Obstructive Lung Disease (GOLD). However, definition ACOS has remained unclear all over world, prevalence rate is basically dependent on patient's symptoms or physician's opinion, based questionnaire testing. In current case report, we investigated COPD patients with high levels fractional exhaled nitric oxide (FENO)...
Interferon-γ neutralizing autoantibodies (nIFNγ-autoAbs) are reported in patients with disseminated nontuberculous mycobacteria (NTM) infection and may function by increasing the risk. Notwithstanding, prevalence of nIFNγ-autoAbs as well clinical presentation, diagnosis, natural history NTM these is poorly understood.In this retrospective observational study, data sera for 331 Japanese subjects mycobacterial were collected analyzed. IFNγ-autoAb titers quantified using an enzyme-linked...
BackgroundThis multicenter phase 2 trial evaluated the safety and efficacy of osimertinib platinum-based chemotherapy (OPP) in patients with previously untreated EGFR-mutated advanced non-squamous non-small cell lung cancer (NSCLC).Patients methodsPatients received 80 mg once daily (QD), either cisplatin 75 mg/m2 (arm A) or carboplatin (area under curve [AUC] = 5; arm B), plus pemetrexed 500 for four cycles maintenance therapy QD every 3 weeks. The primary end-points were objective response...
The prognosis of glioblastoma (GBM) remains poor; therefore, effective therapeutic strategies need to be developed. CD40 is a costimulatory molecule whose agonistic antibody has been shown activate antitumor effects. Recently, extensively targeted for immunotherapeutic purposes. Expressions CD40/CD40L mRNAs were examined in 86 cases World Health Organization grade IV GBM and 36 III gliomas correlated with outcomes. signaling was employed augment the efficacy immunotherapy against gliomas....
Background Pneumonia is a common cause of illness and death the elderly in Japan. Its prevalence escalating globally with aging population. To describe latest trends pneumonia hospitalizations, especially aspiration (AP) cases, we assessed clinical records patients admitted to core acute care hospitals Miyagi prefecture, Methods A retrospective multi-institutional joint research was conducted for hospitalized aged ≥20 years from January 2019 December 2019. Clinical data were collected...
In recent clinical practice, driver gene mutations have been tested using multiplex PCR or next-generation sequencing (NGS), which help determine treatment strategies for non-small cell lung cancer (NSCLC). We developed a new analysis system, the Mutation Investigator Next-era Sequencer (MINtS), NGS, allows detection of even in cytology specimens with low tumor content. Due to its high sensitivity, MINtS has potential detect that are pathologically negative cancer. present study, we examined...
CD40 ligand (CD40L), the for on antigen-presenting cells, is essential initiation of antigen-specific T cell responses, an important component immune response to tumors. This study based hypothesis that in vivo genetic modification tumor cells express CD40L will trigger local present antigen cellular systems, thus eliciting anti-tumor immunity suppress growth tumor. To examine this concept, subcutaneous tumors three different murine models two strains mice were infected with a recombinant...