A5078026176- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Immunotherapy and Immune Responses
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- CAR-T cell therapy research
- Inflammatory Myopathies and Dermatomyositis
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Allergic Rhinitis and Sensitization
- Neonatal Respiratory Health Research
- Eosinophilic Esophagitis
- Eosinophilic Disorders and Syndromes
- Mycobacterium research and diagnosis
- Medical Imaging and Pathology Studies
- Respiratory and Cough-Related Research
- Tuberculosis Research and Epidemiology
- COVID-19 Clinical Research Studies
- Gastric Cancer Management and Outcomes
- Pulmonary Hypertension Research and Treatments
- Diagnosis and treatment of tuberculosis
- Noise Effects and Management
- Lung Cancer Treatments and Mutations
- Phagocytosis and Immune Regulation
- Urticaria and Related Conditions
Niigata University
2014-2025
Nikken Sekkei (Japan)
2015-2024
Chiba University
2018-2024
Niigata University Medical and Dental Hospital
2015-2024
Niigata Cancer Center Hospital
2022
BoZo Research Center (Japan)
2008
The University of Tokyo
2002
Interferon-γ neutralizing autoantibodies (nIFNγ-autoAbs) are reported in patients with disseminated nontuberculous mycobacteria (NTM) infection and may function by increasing the risk. Notwithstanding, prevalence of nIFNγ-autoAbs as well clinical presentation, diagnosis, natural history NTM these is poorly understood.In this retrospective observational study, data sera for 331 Japanese subjects mycobacterial were collected analyzed. IFNγ-autoAb titers quantified using an enzyme-linked...
Introduction: Mucus plugs are associated with airway obstruction in severe asthma and involved the formation of activated eosinophils. Benralizumab, an anti-interleukin-5 receptor antibody, markedly reduces not only peripheral blood eosinophils but also eosinophils; however, its effects on mucus have been clarified. In this study, we examined efficacy benralizumab using computed tomography (CT) imaging. Methods: Twelve patients who were administered underwent CT before approximately 4 months...
Abstract Tumor-specific CD8+ T cells play a pivotal role in antitumor immunity and are key target of immunotherapeutic approaches. Intratumoral heterogeneous; Tcf1+ stemlike give rise to their cytotoxic progeny—Tim-3+ terminally differentiated cells. However, where how this differentiation process occurs has not been elucidated. We herein show that can be generated within tumor-draining lymph nodes (TDLN) CD69 expression on tumor-specific controls its through regulating the transcription...
The mortality of coronavirus disease 2019 (COVID-19) is strongly correlated with pulmonary vascular pathology accompanied by severe acute respiratory syndrome 2 (SARS-CoV-2) infection–triggered immune dysregulation and aberrant activation platelets. We combined histological analyses using field emission scanning electron microscopy energy-dispersive X-ray spectroscopy the lungs from autopsy samples single-cell RNA sequencing peripheral blood mononuclear cells to investigate pathogenesis...
Background: Biological agents are essential treatment options for severe asthma, particularly in cases with Type 2 (T2) inflammation, due to their ability improve symptoms, prevent exacerbations, and reduce the use of oral corticosteroids. However, limited data exist regarding long-term effects on lung function, forced expiratory volume one second (FEV₁). This study aimed analyze longitudinal changes FEV₁ before after initiation biological by following over an extended period. Methods:...
Abstract Purpose Auto-antibodies (auto-abs) to type I interferons (IFNs) have been identified in patients with life-threatening coronavirus disease 2019 (COVID-19), suggesting that the presence of auto-abs may be a risk factor for severity. We therefore investigated mechanism underlying COVID-19 exacerbation induced by IFNs. Methods evaluated plasma from 123 measure performed single-cell RNA sequencing (scRNA-seq) peripheral blood mononuclear cells and conducted epitope mapping auto-abs....
Benralizumab, an anti-interleukin-5 receptor chain monoclonal antibody, is used to treat severe asthma and control symptoms or exacerbations. The aim of this study was examine the changes in airway morphology using computed tomography (CT) images accordance with clinical efficacy following administration benralizumab.The benralizumab evaluated 11 patients by analyzing parameters, such as test, quality life questionnaire, pulmonary function, exacerbation count. We also investigated wall...
A 59‐year‐old Japanese man diagnosed with interstitial lung disease associated amyopathic dermatomyositis anti‐melanoma differentiation‐associated gene 5 ( MDA ‐5) antibodies was treated intravenous methyl prednisolone PSL ) 1000 mg, oral 1 mg/kg, and cyclosporin 200 mg daily. His respiratory condition worsened after treatment two times of cyclophosphamide another steroid pulse therapy as well cyclosporin. Addition mycophenolate mofetil MMF ), 1.5 g daily improved PaO 2 / FiO PF ratio the...
Very recently, a modest but significant efficacy of granulocyte-macrophage colony-stimulating factor (GM-CSF) inhalation therapy for the treatment mild to moderate autoimmune pulmonary alveolar proteinosis (aPAP) has been reported. As ability measure level GM-CSF autoantibody (GMAb) in serum is required decide indication this therapy, we developed high-performance GMAb testing kit clinical use. succeeded reducing nonspecific IgG binding ELISA plate, predictive performance shown training...
Anaplastic lymphoma kinase (ALK)-positive lung cancer is a rare that occurs in approximately 5% of non-small-cell (NSCLCs) patients. Despite the excellent efficacy ALK-tyrosine inhibitor ALK-positive NSCLCs, most patients experience resistance. We conducted phase II study to investigate combination alectinib with bevacizumab NSCLC after failure alectinib. In this study, nonsquamous previously treated received 15 mg/kg on day 1 every 3 weeks and 600 mg/day until disease progression. The...
In the present survey, historical data for spontaneous tumors observed in our laboratory was compared relation to time-related changes between recent (2000-2004) and past (1990-1999) samples from Fischer 344 rats used carcinogenicity studies. samples, there were statistically increased incidences of islet cell adenomas males uterine adenocarcinomas females. On other hand, decreased pheochromocytomas, prostatic adenomas, pituitary anterior large granular lymphocytic (LGL) leukemias Leydig...