A5066882766- Mast cells and histamine
- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- Receptor Mechanisms and Signaling
- IL-33, ST2, and ILC Pathways
- Urticaria and Related Conditions
- Adenosine and Purinergic Signaling
- Tuberous Sclerosis Complex Research
- Dental materials and restorations
- Immune Response and Inflammation
- Polyamine Metabolism and Applications
- Renal and related cancers
- Allergic Rhinitis and Sensitization
- Reconstructive Surgery and Microvascular Techniques
- Pediatric health and respiratory diseases
- Vitamin D Research Studies
- Renal cell carcinoma treatment
- Bone Metabolism and Diseases
- Oral health in cancer treatment
- Dental Erosion and Treatment
- Medical and Biological Sciences
- melanin and skin pigmentation
- Monoclonal and Polyclonal Antibodies Research
- Eosinophilic Esophagitis
- Advanced materials and composites
South Australia Pathology
2013-2025
Centre for Cancer Biology
2013-2025
University of South Australia
2016-2025
University Health Network
2020
Princess Margaret Cancer Centre
2020
Chinese University of Hong Kong
2005-2014
Singapore General Hospital
2007-2009
University of Hong Kong
1998-2005
Infineon Technologies (Singapore)
2003
Queen Mary Hospital
1998
Abstract Acute respiratory distress syndrome (ARDS) is triggered by various aetiological factors such as trauma, sepsis and viruses including SARS-CoV-2 influenza A virus. Immune profiling of severe COVID-19 patients has identified a complex pattern cytokines granulocyte macrophage-colony stimulating factor (GM-CSF) interleukin (IL)-5, which are significant mediators viral-induced hyperinflammation. This strong response prompted the development therapies that block GM-CSF other individually...
Cross-linkage of the high-affinity immunoglobulin E (IgE) receptor (FcɛRI) on mast cells by antigen ligation has a critical role in pathology IgE-dependent allergic disorders, such as anaphylaxis and asthma. Restraint intracellular signal transduction pathways that promote release cell-derived pro-inflammatory mediators is necessary to dampen activation restore homoeostasis. Here we show ligase Nedd4-2 adaptor Ndfip1 (Nedd4 family interacting protein 1) limit intensity duration...
This study aimed to evaluate whether patients presenting with spontaneous haemorrhage from renal tumours could be accurately diagnosed and initially managed conservatively, the role of imaging in guiding timing type subsequent operation. The clinical features, findings management seven rupture tumour over a 5-year period were reviewed. information various studies was evaluated relation course intervention. consisted six angiomyolipomas one cell carcinoma. In all cases, diagnostic, computed...
Background: There are no published studies comparing the clinical performances of more-viscous glass-ionomer cement (GIC) restorations when placed using conventional and atraumatic restorative treatment (ART) cavity preparation methods to restore root surface caries. Methods: One dentist used encapsulated Fuji IX GP Ketac-Molar 72 74 ART preparations for 15 patients who had received cervicofacial radiation therapy. Two assessors evaluated at six, 12, 24 months retention, marginal defects...
Adenosine is believed to participate in the pathological development of asthma through a mast cell-dependent mechanism. Our study aimed pharmacologically characterize functions adenosine receptor (AR) subtypes (A₁, A(2A) , A(2B) and A₃) primary human cultured cells (HCMC).HCMC were derived from progenitor stem buffy coat effects ligands on basal IgE-dependent histamine release evaluated.Adenosine analogues alone did not induce HCMC degranulation. When activated by anti-IgE after 10 min...
Abstract Objectives Mast cells are believed to contribute the pathogenesis of osteoporosis as their number is increased in osteoporotic bones. Herba Epimedii, Fructus Ligustri Lucidi and Psoraleae three Chinese herbs traditionally for tonifying ‘kidney system’ a herbal formula (ELP) containing respective at weight ratio 5 : 4 1 was shown prevent osteoporosis. This study evaluated if suppression mast cell accumulation activity anti-osteoporotic action ELP. Methods The were boiled under reflux...
Mast cells are pivotal in the pathogenesis of allergy and inflammation. In addition to classical IgE-dependent mechanism involving crosslinking high-affinity receptor for IgE (FcεRI), mast also activated by Toll-like receptors (TLRs) which at center innate immunity. this study, we demonstrated that response LAD2 (a human cell line) anti-IgE was altered presence TLR2 agonists peptidoglycan (PGN) tripalmitoyl-S-glycero-Cys-(Lys)4 (Pam3CSK4). Pretreatment PGN Pam3CSK4 inhibited induced calcium...
BackgroundPatients with severe asthma can present eosinophilic type 2 (T2), neutrophilic, or mixed inflammation that drives airway remodeling and exacerbations represents a major treatment challenge. The common β (βc) receptor signals for 3 cytokines, GM-CSF, IL-5, IL-3, which collectively mediate T2 neutrophilic inflammation.ObjectiveTo determine the pathogenesis of βc receptor–mediated in to investigate antagonism as therapeutic strategy granulocytic disease.Methodsβc gene expression was...
Mast cells play important roles in innate immunity through their activation via toll-like receptors (TLRs) but also contribute to neuroimmunological responses and inflammation by the neuropeptide substance P (SP) Gα i/o proteins. This study aims compare effects of TLR2 agonists peptidoglycan (PGN) tripalmitoyl-S-glycero-Cys-(Lys)4 (Pam3CSK4) on SP-induced human mast cell activation. The line LAD2 was employed determined assays β-hexosaminidase, IL-8 intracellular calcium. did not cause...
Although the mast cell is a source of nitric oxide (NO), effect NO on human cells has not been defined. This study investigated if exogenous could affect activation.Effects different donors immunoglobulin E (IgE)-dependent activation human-cultured (HCMC) derived from precursors in buffy coat were by measuring histamine release. Intracellular HCMC was monitored with confocal microscopy using fluorescent indicator 4-amino-5-methylamino-2', 7'-difluorofluorescein.Diethylamine NONOate (DEA/NO)...