A5026433459- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Semiconductor Quantum Structures and Devices
- Semiconductor Lasers and Optical Devices
- Respiratory Support and Mechanisms
- Respiratory and Cough-Related Research
- Neonatal Respiratory Health Research
- Nitric Oxide and Endothelin Effects
- Sulfur Compounds in Biology
- Inhalation and Respiratory Drug Delivery
- Immune Response and Inflammation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- Photonic and Optical Devices
- Pediatric health and respiratory diseases
- COVID-19 Clinical Research Studies
- Allergic Rhinitis and Sensitization
- Cholesterol and Lipid Metabolism
- Lung Cancer Treatments and Mutations
- Quantum and electron transport phenomena
- Neuroscience of respiration and sleep
- SARS-CoV-2 and COVID-19 Research
- Advanced Semiconductor Detectors and Materials
- Immune Cell Function and Interaction
- Sarcoidosis and Beryllium Toxicity Research
Tohoku University
2016-2025
Tohoku University Hospital
2014-2023
Kanazawa University
2021
Nihon University
2021
Kunming University of Science and Technology
2021
Wuyi University
2021
Zhengzhou University
2021
Sun Yat-sen University
2021
Université Laval
2021
Justus-Liebig-Universität Gießen
2021
Matrix metalloproteinase-9 (MMP-9) is a matrix-degrading enzyme implicated in many biological processes, including inflammation. It produced by cells, fibroblasts. When cultured three-dimensional (3D) collagen gels, fibroblasts contract the surrounding matrix, function that thought to model contraction characterizes both normal wound repair and fibrosis. The current study was designed evaluate role of endogenously MMP-9 fibroblast 3D gels. Fibroblasts from mice lacking expression human lung...
Peroxynitrite, nitrogen dioxide, and other reactive species (RNS) that are formed in the reaction of nitric oxide (NO) with superoxide anion, peroxidase-dependent mechanisms, have a potent inflammatory action. These molecules may therefore increase number role airway diseases. In present study, we quantified RNS using immunostaining nitrotyrosine inducible NO synthase (iNOS) cells obtained by induced sputum technique, also exhaled concentration subjects chronic obstructive pulmonary disease...
Fibroblasts are believed to be the major cells responsible for production and maintenance of extracellular matrix. Alterations in fibroblast functional capacity, therefore, could play a role pathogenesis pulmonary emphysema, which is characterized by inadequate tissue structure.
Idiopathic pulmonary fibrosis (IPF) is a disease with poor prognosis. Although the median survival 3 years, clinical course varies to large extent among IPF patients. To date, there has been no definitive prognostic marker. Extracellular vesicles (EVs) are known hold nucleic acid, including microRNAs, and regulate gene expression in recipient cells. Moreover, EVs have shown express distinct surface proteins or enveloped microRNAs depending on parent cell pathological condition. We aimed...
Abstract Background Repetition of the onset aspiration pneumonia in aged patients is common and causes chronic inflammation. The inflammation induces proinflammatory cytokine production atrophy muscles. cytokines induce muscle proteolysis by activating calpains caspase‐3, followed further degradation ubiquitin‐proteasome system. Autophagy another pathway atrophy. However, little known about relationship between muscle. For swallowing muscles, it not clear whether they produce cytokines. main...
Supersulphides are inorganic and organic sulphides with sulphur catenation diverse physiological functions. Their synthesis is mainly mediated by mitochondrial cysteinyl-tRNA synthetase (CARS2) that functions as a principal cysteine persulphide synthase (CPERS). Here, we identify protective of supersulphides in viral airway infections (influenza COVID-19), aged lungs chronic lung diseases, including obstructive pulmonary disease (COPD), idiopathic fibrosis (IPF). We develop method for breath...
Abstract Background Japanese guidelines recommend triple inhaled corticosteroid (ICS)/long-acting muscarinic antagonist (LAMA)/long-acting β 2 -agonist (LABA) therapy in patients with chronic obstructive pulmonary disease (COPD) and no concurrent asthma diagnosis who experience frequent exacerbations have blood eosinophil (EOS) count ≥ 300 cells/mm 3 , COPD continuing/worsening symptoms despite receiving dual ICS/LABA therapy. These post-hoc analyses of the KRONOS study without an diagnosis,...
Asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) was proposed by the science committees of both Global Initiative for Asthma (GINA) and Chronic Obstructive Lung Disease (GOLD). However, definition ACOS has remained unclear all over world, prevalence rate is basically dependent on patient's symptoms or physician's opinion, based questionnaire testing. In current case report, we investigated COPD patients with high levels fractional exhaled nitric oxide (FENO)...
Oxidative stress is a major aetiological factor driving chronic obstructive pulmonary disease (COPD). Recently recognised as potent antioxidants, reactive persulfide and polysulfide species are biosynthesised by cystathionine β-synthase γ-lyase. The production of in the lungs patients with COPD remain unknown.The aim this study was to examine persulfides polysulfides, such glutathione (GSSH), cysteine (CysSSH) trisulfide (GSSSH), lung-resident cells epithelial lining fluid (ELF) obtained...
We study the basic physical mechanisms determining temperature dependence of threshold current (I/sub th/) InP-based strained-layer (SL) quantum-well (QW) lasers emitting at a wavelength 1.3 /spl mu/m. show that I/sub th/ exhibits different above and below critical T/sub c/. It is indicated c/ maximum which gain linear relationship with temperature. demonstrate Auger recombination dominates th/. On other hand, significant increase in both internal loss radiative...
Focal fatty change of the liver adjacent to falciform ligament: CT and sonographic findings in five surgically confirmed casesJ Yoshikawa, O Matsui, T Takashima, H Sugiura, K Katayama, Y Nishida M TsujiAudio Available | Share
Measurement of the exhaled nitric oxide fraction (FEno) has been proposed as a useful diagnostic test for asthma. However, most data concerning fEno cutoff values diagnosis asthma have not yet examined using standard procedures. Furthermore, there is no detailed study that investigated takes into account patient factors influence FEno levels. Methods: was measured in 142 steroid-naive asthmatics and 224 control subjects an online electrochemical analyzer accordance with current guidelines....
Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, and its possible involvement in pathophysiology of COPD viral-induced exacerbations has been demonstrated. IL-33 shown be increased airway epithelial cells from patients, but regulating mechanism expression remains largely unknown. In current study, we examined whether oxidative stress, which participates pathogenesis COPD, affects also evaluated effect during viral infection. The stress IL-33, signal pathway was after...
Airway remodeling is observed in the airways of patients with asthma, and differentiation fibroblasts to myofibroblasts plays a critical role progress airway remodeling. Viral infection induces not only disease development exacerbations but also The aim this study was evaluate whether activation Toll-like receptor 3 (TLR3) can affect extracellular matrix (ECM) protein production. Human fetal lung (HFL-1) adult were treated synthetic double-stranded RNA, polyinosine-polycytidylic acid...
Fibrotic diseases are characterized by the accumulation of extracellular matrix together with distortion and disruption tissue architecture. Phosphodiesterase (PDE)4 inhibitors, preventing breakdown cAMP, can inhibit fibroblast functions may be able to mitigate remodeling. Transforming growth factor (TGF)-beta1, a mediator fibrosis, potentially modulate cAMP altering PGE(2) metabolism. The present study assessed whether PDE4 inhibitors functionally antagonize profibrotic activity fibroblasts...
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