A5064879694- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Asthma and respiratory diseases
- Lung Cancer Treatments and Mutations
- Neonatal Respiratory Health Research
- Blood Coagulation and Thrombosis Mechanisms
- Pulmonary Hypertension Research and Treatments
- Peptidase Inhibition and Analysis
- Respiratory Support and Mechanisms
- Protease and Inhibitor Mechanisms
- Lung Cancer Research Studies
- Inhalation and Respiratory Drug Delivery
- TGF-β signaling in diseases
- Tracheal and airway disorders
- Colorectal Cancer Treatments and Studies
- Pediatric health and respiratory diseases
- Medical Imaging and Pathology Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Phagocytosis and Immune Regulation
- Cancer Immunotherapy and Biomarkers
- Cell death mechanisms and regulation
- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Atrial Fibrillation Management and Outcomes
- Cardiac tumors and thrombi
Mie University
2016-2025
Tsu City College
2016-2024
Tokyo Metropolitan University
2022-2024
Osaka Metropolitan University
2022-2024
Mie University Hospital
2016-2023
Soka Municipal Hospital
2020-2021
Osaka City University
2018-2021
Jesse Brown VA Medical Center
2020
University of Illinois Chicago
2020
Hyogo Prefectural Amagasaki General Medical Center
2019
Abstract The neonatal FcR (FcRn) binds to the Fc domain of IgG at acidic pH in endosome and protects from degradation, thereby contributing long serum half-life IgG. To date, more than 20 mAb products 5 Fc-fusion protein have received marketing authorization approval United States, European Union, or Japan. Many these therapeutic proteins human IgG1; however, half-lives differ each protein. elucidate role FcRn pharmacokinetics domain-containing proteins, we evaluated affinity clinically used...
<b>Objective</b> To determine the efficacy of a 23-valent pneumococcal polysaccharide vaccine in people at high risk pneumonia. <b>Design</b> Prospective, randomised, placebo controlled double blind study. <b>Setting</b> Nursing homes Japan. <b>Participants</b> 1006 nursing home residents. <b>Interventions</b> Participants were randomly allocated to either (n=502) or (n=504). <b>Main outcome measures</b> The primary end points incidence all cause pneumonia and Secondary deaths from...
Matrix metalloproteinase-9 (MMP-9) is a matrix-degrading enzyme implicated in many biological processes, including inflammation. It produced by cells, fibroblasts. When cultured three-dimensional (3D) collagen gels, fibroblasts contract the surrounding matrix, function that thought to model contraction characterizes both normal wound repair and fibrosis. The current study was designed evaluate role of endogenously MMP-9 fibroblast 3D gels. Fibroblasts from mice lacking expression human lung...
Abstract Idiopathic pulmonary fibrosis is an incurable disease of unknown etiology. Acute exacerbation idiopathic associated with high mortality. Excessive apoptosis lung epithelial cells occurs in acute exacerbation. We recently identified corisin, a proapoptotic peptide that triggers fibrosis. Here, we provide insights into the mechanism underlying processing and release corisin. Furthermore, demonstrate anticorisin monoclonal antibody ameliorates by significantly inhibiting human...
Bone marrow (stem/progenitor) cells have been shown to "differentiate" into in multiple tissues, including lung. A low number of hematopoietic stem/progenitor also circulate peripheral blood. The physiologic roles these are still uncertain. This study was designed test, using parabiotic mice that were joined surgically, whether blood contributed the regeneration lung after injury. Parabiotic generated surgically by joining green fluorescent protein transgenic and wild-type littermates. These...
It is well recognized that activation of the coagulation system plays an important role in bleomycin (BLM)-induced lung injury and fibrosis. The protein C (PC) pathway regulator system. In this study, we evaluated bronchoalveolar lavage fluid (BALF) concentration activated PC (APC) therapeutic effect intratracheal administration APC on BLM-induced fibrosis mice. levels BALF were significantly lower BLM-treated animals than saline-treated group. Fibrotic changes progressive mice treated with...
Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal disease of unknown etiology; however, apoptosis lung alveolar epithelial cells plays role in progression. This intractable associated with increased abundance Staphylococcus Streptococcus the lungs, yet their roles pathogenesis remain elusive. Here, we report that nepalensis releases corisin, peptide conserved diverse staphylococci, to induce cells. The mice exhibits acute exacerbation after intrapulmonary instillation...
Bronchial asthma is a chronic disease characterized by inflammation, obstruction, and hyperresponsiveness of the airways. There currently no curative therapy for asthma. Type 2 helper T cell response plays critical role in pathogenesis disease. Protein S glycoprotein endowed with anticoagulant, anti-inflammatory, anti-apoptotic properties. Whether protein can suppress bronchial be useful its unknown.To address this question here we compared development allergen-associated between wild type...
Section:ChooseTop of pageAbstract <<MATERIALS AND METHODSRESULTSDISCUSSIONReferencesCITING ARTICLES
Eosinophilic inflammation and remodeling of the airways including subepithelial fibrosis myofibroblast hyperplasia are characteristic pathological findings bronchial asthma. Epithelial to mesenchymal transition (EMT) plays a critical role in airway remodelling. In this study, we hypothesized that infiltrating eosinophils promote remodelling To demonstrate hypothesis evaluated effect on EMT by vitro vivo studies. was assessed mice received intra-tracheal instillation mouse bone marrow derived...
Abstract Background Immune checkpoint inhibitors have recently become the standard of care in first‐line treatment extensive‐stage small cell lung cancer. Although immune‐related adverse events been reported to influence prognosis non‐small cancer patients, few studies investigated prognostic value patients. In this study, we evaluated patients who developed after with immune inhibitor‐based chemotherapy for Methods We enrolled 90 received as from September 2019 December 2022 six hospitals...
BACKGROUND: The peripheral blood concentrations of several proteases the clotting system have been shown to predict survival in patients with malignancy. A study was undertaken investigate independent value plasma levels D-dimer degradation product fibrin before treatment for predicting prognosis lung cancer. METHODS: comprised 70 cancer (49 non-small cell and 21 small cancer). Plasma were measured using an enzyme immunoassay kit. Multivariate statistical analysis carried out Cox's...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Apoptosis of lung structural cells is crucial in the process normal tissue repair. Insufficient apoptosis fibroblasts may contribute to development fibrosis. Since CC chemokine ligand 2 (CCL2) associated with fibrotic disease and cytokine IL-6 blocks many cell types, we hypothesized that CCL2 fibrosis by inducing IL-6, which, turn, inhibits fibroblast apoptosis. Fibroblasts were cultured presence CCL2, which stimulated production mRNA expression a concentration-dependent manner (250-1,000...
Abstract Background We have previously reported that low concentrations of cigarette smoke extract induce DNA damage without leading to apoptosis or necrosis in human bronchial epithelial cells (HBECs), and IL-6/STAT3 signaling contributes the cell survival. Since NF-κB is also involved regulating survival, current study was designed investigate role mediating survival response exposure HBECs. Methods Both pharmacologic inhibitor NF-κB, curcumin, RNA interference targeting p65 were used...
Fibrotic diseases are characterized by the accumulation of extracellular matrix together with distortion and disruption tissue architecture. Phosphodiesterase (PDE)4 inhibitors, preventing breakdown cAMP, can inhibit fibroblast functions may be able to mitigate remodeling. Transforming growth factor (TGF)-beta1, a mediator fibrosis, potentially modulate cAMP altering PGE(2) metabolism. The present study assessed whether PDE4 inhibitors functionally antagonize profibrotic activity fibroblasts...
Interstitial lung diseases (ILD) are characterized by progressive interstitial pulmonary fibrosis and a decline in function. Fibrocytes bone marrow-derived mesenchymal progenitor cells that may play role the pathogenesis of fibrosis. Circulating fibrocyte numbers have been correlated with prognosis patients idiopathic The aim present study was to evaluate relationship between circulating fibrocytes, parameters disease activity progression several groups ILD.The population comprised 41 ILD...
Idiopathic pulmonary fibrosis is a chronic devastating disease of unknown etiology. No therapy currently available. A growing body evidence supports the role transforming growth factor (TGF)-β1 as major player in pathogenesis disease. However, attempts to control its expression and improve outcome have been disappointing. We tested hypothesis that TGF-β1 dominant acute phases developed short interfering (si)RNAs directed toward molecules implicated This study novel sequences siRNAs targeting...