A5033857037- Mechanical stress and fatigue analysis
- T-cell and Retrovirus Studies
- HIV Research and Treatment
- Engineering Structural Analysis Methods
- Fatigue and fracture mechanics
- Mechanical Behavior of Composites
- Metal Forming Simulation Techniques
- Immune Cell Function and Interaction
- Vibration and Dynamic Analysis
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Galectins and Cancer Biology
- Tuberculosis Research and Epidemiology
- HIV/AIDS drug development and treatment
- Electrical Contact Performance and Analysis
- Mycobacterium research and diagnosis
- Structural Load-Bearing Analysis
- Bone and Dental Protein Studies
- Engineering Applied Research
- Mechanical Failure Analysis and Simulation
- High-Velocity Impact and Material Behavior
- Mechanical Engineering and Vibrations Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Crystallization and Solubility Studies
- COVID-19 Clinical Research Studies
Tohoku University
2010-2024
Kibi International University
2016-2024
Gifu University
2007-2023
University of Shizuoka
2023
Nihon University
2017-2019
University of Milan
2018
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2018
Shizuoka Institute of Science and Technology
2014-2018
National Research Institute of Fire and Disaster
1992-2016
National Disaster Medical Center
2012
A monoclonal antibody was produced to the exterior envelope glycoprotein (gp120) of human T-cell lymphotropic virus (HTLV)-IIIB isolate immunodeficiency (HIV). This binds gp120 HTLV-IIIB and lymphadenopathy-associated type 1 (LAV-1) surface HTLV-IIIB- LAV-1-infected cells, neutralizes infection by cell-free virus, prevents fusion virus-infected cells. In contrast, it does not bind, or weakly binds, four heterologous HIV isolates neutralize HTLV-IIIRF HTLV-IIIMN. The antibody-binding site...
The penetration of various viruses into host cells is accomplished by hijacking the endocytosis machinery. In case severe acute respiratory syndrome coronavirus (SARS-CoV) infection, viral entry reported to require a low pH in intracytoplasmic vesicles; however, little known about how SARS-CoV invades such compartments. Here we demonstrate that mainly utilizes clathrin-mediated pathway for its target using infectious SARS-CoV, as well pseudovirus packaged envelope. entered...
The adult T cell leukemia (ATL) is a neoplasm etiologically associated with human lymphotropic virus type I (HTLV-I) infection. ATL cells often abnormally express interleukin 2 (IL-2) receptors, and patients may show clinical evidence of hypercalcemia, osteolytic bone lesions, or increased turnover. Whereas 1 (IL-1) not generally recognized as product cells, this cytokine capable both altering IL-2 receptor expression activating osteoclasts. Thus, we investigated the possibility that primary...
When murine thymocytes were stimulated by mitogens such as concanavalin A, the Ca2+ ionophore A23187, or 4 beta-phorbol 12-myristate 13-acetate, there was a marked increase of 32P incorporation into immunoprecipitable lipomodulin, phospholipase inhibitory protein. These compounds enhanced 45Ca2+ influx thymocytes, which, in turn, increased protein phosphorylation, probably Ca2+- and phospholipid-dependent kinase (protein C). Cyclic 8-bromo-AMP, an inhibitor lymphocyte mitogenesis, blocked...
Along with large-scale loss of life, infrastructural damage, and material losses, health issues have become a crucially important problem after natural disasters. Survivors must confront the threat risks, especially infectious diseases, as result limited supplies, services, facilities. Limited knowledge about risks following disasters, in addition to lack awareness, contributes occurrence diseases that are fundamentally preventable. This study was conducted review eight major disasters...
Apart from localized gastrointestinal infections, Escherichia coli and Salmonella species are major causes of systemic disease in both humans animals. spp. cause invasive infections such as enteric fever, septicemia, osteomyelitis meningitis while certain types E. can including pyelonephritis, septicemia. These characteristic requires the involvement a myriad virulence factors. This study investigated factors clinical specimens patients with diarrhoea presenting to health care centres Oliver...
Galectin-9 (Gal-9), a β-galactoside binding mammalian lectin, regulates immune responses by reducing pro-inflammatory IL-17-producing Th cells (Th17) and increasing anti-inflammatory Foxp3(+) regulatory T (Treg) in vitro vivo. These functions of Gal-9 are thought to be exerted receptor molecules on the cell surface. However, lacks signal peptide for secretion is predominantly located cytoplasm, which raises questions regarding how secrete Since expression does not necessarily correlate with...
Trypstatin, a new cellular Kunitz‐type protease inhibitor purified from rat mast cells, inhibited syncytium formation in human immunodeficiency virus type 1 (HIV‐1)‐infected CCRF‐CEM and uninfected Molt‐4 clone 8 at concentration of μM. Anti‐rat tongue cell tryptase antibodies reacted with as determined by Western blot immunofluorescence. In addition, the antibody formation. These findings along homologous sequences trypstatin neutralizing epitope gp120 HIV‐1 suggest that tryptase‐like...
A trans-acting regulatory gene product p40tax (Tax) of human T-cell leukemia virus type I (HTLV-I) is one the main target antigens recognized by cytotoxic T lymphocytes (CTL) specific for HTLV-I. CTL epitope within Tax protein was identified in this report. HTLV-I-specific CD8+ lines established from two HTLV-I carriers with HTLV-I-associated myelopathy or Sjögren syndrome were previously demonstrated to kill predominantly cells expressing Tax. The patients showed significant levels...
Epigallocatechin gallate (EGCG), the most abundant catechin in green tea, has been reported to inhibit HIV-1 replication prior its integration into host DNA via various proposed mechanisms; however, specific main target(s) of EGCG remain unclear. In this study, we investigated a number these detailed mechanism(s) using cell-based model.Multinuclear activation galactosidase indicator assays were used for all experiments, including examination time addition and synergisms with nucleoside...
SUMMARY Dengue fever (DF) and leptospirosis are serious public problems in tropical regions, especially Manila, the Philippines. In attempting to understand causes of DF seasonality, meteorological factors have been suspected, but quantitative correlation between seasonality has not fully investigated. this study, we investigated temporal patterns reported numbers laboratory-confirmed cases both with conditions (temperature, relative humidity, rainfall) Manila. We used time-series analysis...
Objective: The aim of this study was to improve the detection COPD in a primary care setting and evaluate subsequent management these patients by general practitioners. Methodology: A two‐step protocol followed: were screened for airway obstruction their status reviewed. Screening spirometry performed 56 settings (23 hospitals 33 practices). Inclusion criteria screening subjects were: (i) ≥40‐year‐old smokers (both current past smokers) and/or (ii) with respiratory symptoms chronic cough...
Effects of human fibroblast (beta) or leukocyte (alpha) interferon (IFN) on differentiations a histiocytic lymphoma-derived cell line (U937) promyelocytic leukemia-derived (HL-60) were studied. When cultured with beta-IFN (400-1,000 U/ml), U937 cells showed gross morphologic and microscopic changes consisting clumping, increased cytoplasmic-to-nuclear ratio, enhanced prominence cytoplasmic granules, membrane ruffling. After culture beta-IFN, the number reactive B43.4.1 monoclonal antibody,...
For the last decade China has occupied second place, after India, among top five countries with high burdens of tuberculosis (TB). Heilongjiang Province is located in northeastern China. The prevalence drug-resistant TB higher than average level To determine transmission characteristics Mycobacterium strains isolated this area and their genetic relationships, especially Beijing family strains, we investigated genotypes. From May 2007 to October 2008, 200 M. isolates from patients presenting...
Several herbs are traditionally used in the treatment of a variety ailments particularly rural areas South Africa where herbal medicine is mainly source health care system. Many these have not been assessed for safety or toxicity to tissue organs mammalian recipients.