A5063819703- Moyamoya disease diagnosis and treatment
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Intracranial Aneurysms: Treatment and Complications
- T-cell and Retrovirus Studies
- Liver Disease and Transplantation
- Neurological Complications and Syndromes
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Immunodeficiency and Autoimmune Disorders
- Cerebrovascular and Carotid Artery Diseases
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Multiple Myeloma Research and Treatments
- T-cell and B-cell Immunology
- Vector-Borne Animal Diseases
- Glycosylation and Glycoproteins Research
- Hematopoietic Stem Cell Transplantation
- Inflammatory mediators and NSAID effects
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Folate and B Vitamins Research
- Biochemical and Molecular Research
Hokkaido University
2016-2025
Stanford University
2020-2025
Hokkaido University Hospital
2011-2024
Montreal General Hospital
2024
University of Toyama
2016-2022
Stanford Medicine
2021
Hokkaido University of Science
2021
Tokyo Medical University
1999-2019
Kurashiki Central Hospital
2015-2019
Kyoto University
1988-2017
Abstract A nation‐wide sero‐epidemiologic survey of adult T‐cell leukemia virus (ATLV), detected es anti‐ATLA (ATLV‐associated antigen), was made in Japan. Sera from donors 15 different locations were screened for anti‐ATLA. High incidences (6 to 37%) antibody‐positive found seven regions, one northern Japan, and the others southwestern regions. These areas are ATLV‐endemic corresponding ATL‐endemic areas. Examination sera healthy aged 6 80 years showed an age‐dependent increase seropositive...
Two-color fluorescence analysis revealed that Tac antigen, which was previously reported to be restricted T cells, expressed on a proportion of normal B cells activated by Staphylococcus aureus Cowan I (SAC). Immunoaffinity-purified interleukin 2 (IL-2) induced the proliferation SAC-activated and completely inhibited anti-Tac antibody, blocked membrane binding action IL-2. These results suggest an IL-2 receptor system is directly involved in cell immune response.
The "congestion index" is used to mean the ratio between cross-sectional area (cm2) and blood flow velocity (cm/sec) of portal vein, as determined by a duplex Doppler system. indices in normal subjects patients with liver disease were follows: (n = 85), 0.070 +/- 0.029 cm X sec; acute hepatitis 11), 0.071 0.014 chronic active 42) 0.119 0.084 cirrhosis 72), 0.171 0.075 idiopathic hypertension 0.180 0.107 sec. There was statistically significant difference congestion from subject group...
We studied the expression of interleukin-2 (IL-2) receptor and proliferative response to exogenous IL-2 peripheral blood leukemic cells from patients with adult T cell leukemia (ATL) in order see whether expressed on ATL is different normal it plays a role neoplastic growth ATL. Peripheral 42 examined receptors that were detected by anti-Tac monoclonal antibody when immediately after separation or culture for 24 48 h. The number binding sites ranged 3,100 11,400 fresh 3,600 96,000/cell...
Abstract The ultrasonic duplex system, which is composed of a pulsed Doppler flow‐meter and linear array B‐mode scanner, was developed for the purpose quantitative transcutaneous measurement blood flow. It applied here to study portal flow in normal series with healthy volunteers as subjects. A preliminary experiment, prepared by setting up simulation model circulation, demonstrated an excellent correlation between values obtained electromagnetic flowmeter (EMF) combined system (duplex...
Clinical features and pathophysiology of postoperative hyperperfusion in moyamoya disease are still unclear. This study was aimed to clarify the incidence time course determine independent predictors disease.This prospective included 41 patients who underwent surgical revascularization for disease. Using (15)O-gas positron emission tomography, hemodynamic metabolic parameters were quantified before surgery. single photon computed cerebral blood flow serially measured just after surgery on 2...
Long-term outcomes are unknown in patients with asymptomatic moyamoya disease. In this report, we aimed to clarify their 5-year risk of stroke and its predictors.We conducting a multicenter, prospective cohort study (Asymptomatic Moyamoya Registry) Japan. Participants were eligible if they 20 70 years, had bilateral or unilateral disease, experienced no episodes suggestive TIA stroke; functionally independent (modified Rankin Scale score 0-1). Demographic radiological information was...
Abstract. The incidence of selective IgA deficiency (SIgAD) was determined in a healthy adult population 222,597 Japanese volunteer blood donors. Of the donors screened, only 0.007% (1:14,840) were found to be IgA‐deficient (less than 10 mg/dl) by means double diffusion method, while 0.005% (1:18,500) less 5 mg/dl, and 0.003% (1:31,800) 1 mg/dl single radial immunodiffusion method. Statistical analysis results clearly showed that SIgAD is very much lower European ancestry. may occupy unique...
Background: The mechanism of the neuroprotective effects propofol was compared to two other types intravenous (i.v.) anesthetics (i.e., benzodiazepine; midazolam and barbiturate; pentobarbital) using Mongolian gerbils focusing on GABA receptor subtypes. Methods: Neuronal injury induced by a 4‐min occlusion common carotid arteries followed reperfusion. One week after occlusion, animals were transcardially perfused for histochemistry. death in four brain regions evaluated direct visual...
Human cytotoxic T cells (Tc) specific for autologous adult cell leukemia virus- (ATLV) bearing were induced in vitro. Peripheral blood leukocytes (PBL) from healthy donors stimulated repeatedly with ATLV-bearing cells. In two out of four seropositive and one seronegative donors, the responder showed cytotoxicity cells, but not PBL, cloned lines, Epstein Barr virus-transformed lymphoblastoid B line (LCL) or various ATLV-negative The effector possessing Leu-1 Leu-2a antigens that able to...
Human interleukin 2 receptors ( IL2R ) from various cell sources such as mitogen-activated normal human T cells, adult leukemia (ATL)-derived line cells (MT-1, ATL-6, Hut-102), and a natural killer-like YT were studied both by one- two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), with monoclonal anti- antibody (anti-Tac). In synthetic labeling [35S]methionine, anti-Tac specifically precipitated two glycoproteins, one m.w. of 60,000 to 65,000 pI 4.2 4.7,...
Whether additional indirect bypasses effectively contribute to revascularization in combined procedures remains unclear patients with moyamoya disease.To evaluate the longitudinal changes associated while following up pediatric and adult long term assess whether any other clinical factors or hemodynamic parameters affected these determine an optimal surgical strategy.We studied 58 hemispheres 43 adults 39 26 children who underwent for disease. To bypass development, we assessed sizes of...