A5101932666- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Schizophrenia research and treatment
- Parkinson's Disease Mechanisms and Treatments
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Blood groups and transfusion
- Microtubule and mitosis dynamics
- Genetic Neurodegenerative Diseases
- Metabolism and Genetic Disorders
- Bipolar Disorder and Treatment
- Peroxisome Proliferator-Activated Receptors
- Diabetes Treatment and Management
- Systemic Lupus Erythematosus Research
- DNA Repair Mechanisms
- T-cell and B-cell Immunology
- Effects and risks of endocrine disrupting chemicals
- Ethics in Clinical Research
- Moyamoya disease diagnosis and treatment
- Musculoskeletal pain and rehabilitation
- Rheumatoid Arthritis Research and Therapies
- Immune Cell Function and Interaction
- Meningioma and schwannoma management
Hokkaido University Hospital
2010-2024
Tohoku University
2018
Okayama University
2018
Asahi Kasei (Japan)
2002-2017
Hokkaido University
2004-2010
Kyushu University
1998-2001
Single-incision laparoscopic cholecystectomy (SILC) is a promising alternative to standard multi-incision (LC). However, generalization of SILC still hampered by technical difficulties mainly associated with the lack trocars used for retraction gallbladder. We therefore developed modified method use needle graspers (SILC-N) optimal and exposure.In addition two inserted through single transumbilical incision, ports were placed on right subcostal lateral abdominal wall, which Since December,...
Potent immunosuppressive drugs have significantly improved early patient survival after liver transplantation (LT). However, long‐term results remain unsatisfactory because of adverse events that are largely associated with lifelong immunosuppression. To solve this problem, different strategies been undertaken to induce operational tolerance, for example, maintenance normal graft function and histology without therapy, but achieved limited success. In pilot study, we aimed tolerance using a...
Long-term outcomes are unknown in patients with asymptomatic moyamoya disease. In this report, we aimed to clarify their 5-year risk of stroke and its predictors.We conducting a multicenter, prospective cohort study (Asymptomatic Moyamoya Registry) Japan. Participants were eligible if they 20 70 years, had bilateral or unilateral disease, experienced no episodes suggestive TIA stroke; functionally independent (modified Rankin Scale score 0-1). Demographic radiological information was...
During mitosis, 2 centrosomes ensure accurate assembly of bipolar spindles and fidelity the chromosomal segregation. The presence more than copies during mitosis can result in formation multipolar spindles, unbalanced chromosome segregation, aneuploidy. Recent studies have provided evidence that centrosome hyperamplification plays a pivotal role carcinogenesis. Using immunofluorescence analysis with gamma-tubulin pericentrin antibodies, paraffin-embedded sections from 40 malignant biliary...
Abstract: Objectives : Some studies have indicated patients who received rituximab as adjuvant to stem cell transplantation had an increased risk of developing severe hypogammaglobulinemia. The mechanism this hypogammaglobulinemia is unknown, although investigators hypothesized a further delay in the B‐cell recovery one potential etiology. aim study clarify mechanism(s) Methods A total 14 with high‐risk CD20 + lymphoma underwent autologous peripheral blood (APBSCT). After hematological...
Fatty acid oxidation disorders (FAODs) are rare diseases caused by defects in mitochondrial fatty (FAO) enzymes. While the efficacy of bezafibrate, a peroxisome proliferator-activated receptor agonist, on vitro FAO capacity has been reported, vivo remains controversial. Therefore, we conducted clinical trial bezafibrate Japanese patients with FAODs.This was an open-label, non-randomized, and multicenter study treatment 6 very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency 2 carnitine...
Abstract We report a patient with relapsed in bone marrow of extremities after allogeneic peripheral blood stem cell transplantation for acute lymphoblastic leukemia (ALL). The complained pain the right upper arm and left leg 15 months transplantation. Magnetic resonance imaging (MRI) fluorine‐18 fluorodeoxyglucose positron emission tomography (FDG‐PET) showed abnormal findings lower extremities. There were no relapse aspirates from sternum iliac marrow. Biopsy specimen normocellular without...
Recent studies have indicated that patients who receive stem cell transplantation (SCT) and rituximab demonstrate an increased risk of developing hypogammaglobulinemia. Such hypogammaglobulinemia has been found to be due delayed recovery memory B cells with abnormal marker expression impaired immunoglobulin production in vitro. However, no predictive factors for the levels after autologous SCT therapy reported. The aim this study is clarify relationships between FCGR3A-158V/F genotype serum...
The aim of this study is to determine whether the 'programmed' infliximab (IFX) treatment strategy (for which dose IFX was adjusted based on baseline serum tumour necrosis factor α (TNF-α)) beneficial induction clinical remission after 54 weeks and sustained discontinuation for 1 year.In multicentre randomised trial, patients with IFX-naïve rheumatoid arthritis inadequate response methotrexate were two groups; in programmed group received 3 mg/kg until week 6 14 levels TNF-α 54; standard...
Objectives Multiple system atrophy (MSA) is a refractory neurodegenerative disease, but novel treatments are anticipated. An accurate natural history of MSA important for clinical trials, insufficient. This regional registry was launched to complement information on MSA. Setting Patient recruitment started in November 2014 and ongoing at the time submission. The number participating facilities 66. Postal surveys were sent medical patients with Hokkaido, Japan. Participants After obtaining...
Herniated nucleus pulposus (NP), one of the most common diseases spine, is surgically treated by removing sequestered NP. However, intervertebral disc (IVD) defects may remain after discectomy, leading to inadequate tissue healing and predisposing patients IVD degeneration. An acellular, bioresorbable, ultra-purified alginate (UPAL) gel (dMD-001) implantation system can be used fill any in order prevent degeneration discectomy. This first-in-human pilot study aims determine feasibility,...
The effect of highly active antiretroviral therapy (HAART) on hepatitis C virus (HCV) infection remains uncertain. This report describes the case a man with hemophilia HIV-HCV coinfection persistent disappearance HCV RNA after changing HAART regimen. He had been treated zidovudine, lamivudine, and indinavir for initial HIV level undetectable more than 8 years. suffered from chronic hepatitis. regimen was changed to emtricitabine/tenofovir, atazanavir, ritonavir because patient preferred once...
Abstract Introduction Global data sharing is essential. This the premise of Academic Research Organization (ARO) Council, which was initiated in Japan 2013 and has since been expanding throughout Asia into Europe United States. The volume growing exponentially, providing not only challenges but also clear opportunity to understand treat diseases ways previously considered. Harnessing knowledge within a successful way can provide researchers clinicians with new ideas for therapies while...
Fatty acid oxidation disorders (FAODs) are rare diseases caused by a defective mitochondrial fatty (FAO) enzyme. We recently reported that bezafibrate improved patient quality of life (QOL) based on the SF-36 questionnaire score in patients with FAODs during 50-week, open-label, clinical trial. Herein we conducted further survey assessments trial to define long-term efficacy and safety bezafibrate. This was an non-randomized, multicenter study treatment five very long-chain acyl-CoA...