A5101417476- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Planetary Science and Exploration
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Genetic Syndromes and Imprinting
- Pharmacological Effects and Toxicity Studies
- Lung Cancer Treatments and Mutations
- Astro and Planetary Science
- Genetics and Neurodevelopmental Disorders
- Neurological disorders and treatments
- Neural dynamics and brain function
- Environmental Toxicology and Ecotoxicology
- Glycogen Storage Diseases and Myoclonus
- Marine Biology and Environmental Chemistry
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Alzheimer's disease research and treatments
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Space Exploration and Technology
- Neonatal and fetal brain pathology
- Metabolism and Genetic Disorders
- Diet and metabolism studies
Dokkyo Medical University
2024-2025
Hokkaido University Hospital
2017-2024
Ludwig-Maximilians-Universität München
2024
Friedrich Baur Stiftung
2024
Hokkaido University
2014-2023
Mitsui Memorial Hospital
2020-2023
Iwata City Hospital
2021
Nagasaki University
2006-2017
Nagasaki University Hospital
2017
Stichting Epilepsie Instellingen Nederland
2017
Rates of occurrence and degrees imposex, tissue concentrations organotin compounds (tributyltin, TBT; dibutyltin, DBT; butyltin, MBT; triphenyltin, TPT; diphenyltin, DPT; phenyltin, MPT) in the rock shell, Thais clavigera T. bronni (Mollusca: Gastropoda) were investigated at 32 sites Japan from May 1990 to October 1992. The rate imposex was 100% both species, almost all surveyed. Degrees indicated by relative penis length (RPL) index reflected pollution levels not only TBT, but also TPT. In...
<b>Background: </b> Although detection of concordant lesions on MRI significantly improves postsurgical outcomes in focal epilepsy (FE), many conventional MR studies remain negative. The authors evaluated the role phased array surface coil performed at 3 Tesla (3T PA MRI). <b>Methods: Forty patients with medically intractable epilepsies were prospectively imaged 3T PA-MRI including high matrix TSE T2, fluid attenuated inversion recovery, and magnetization prepared rapid gradient echo. All...
Summary Phthalate esters, commonly used as plasticizers, show anti‐androgenic activity and cause male reproductive malformation in experimental animals. However, the effects of prenatal exposure to phthalate esters humans have not been extensively studied. The purpose this study was examine relationship between anogenital distance (AGD) a endpoint human newborns. Spot urine samples were collected from 111 Japanese pregnant women after obtaining their informed consent. Seven urinary ester...
Abstract Epilepsy of infancy with migrating focal seizures (EIMFS) is one the early-onset epileptic syndromes characterized by polymorphous seizures. Whole exome sequencing (WES) in ten sporadic and familial case EIMFS revealed compound heterozygous SLC12A5 (encoding neuronal K + -Cl − co-transporter KCC2) mutations two families: c.279 1G > C causing skipping exon 3 transcript (p.E50_Q93del) c.572 >T (p.A191V) individuals 1 2, c.967T (p.S323P) c.1243 A G (p.M415V) individual 3. Another...
The human IgG4 monoclonal antibody nivolumab targets programmed cell death-1 (PD-1) and promotes antitumor response by blocking the interaction of PD-1 with its ligands. This single-center phase Ib study investigated tolerability, safety, pharmacokinetics combined standard chemotherapy in patients advanced non-small-cell lung cancer (NSCLC).Patients who had stage IIIB without indication for definitive radiotherapy, IV, or recurrent NSCLC were eligible. Regimens 10 mg/kg +...
Abstract The phase III double-blind PROPEL study compared the novel two-component therapy cipaglucosidase alfa + miglustat (cipa mig) with alglucosidase placebo (alg pbo) in adults late-onset Pompe disease (LOPD). This ongoing open-label extension (OLE; NCT04138277) evaluates long-term safety and efficacy of cipa mig. Outcomes include 6-min walk distance (6MWD), forced vital capacity (FVC), creatine kinase (CK) hexose tetrasaccharide (Hex4) levels, patient-reported outcomes safety. Data are...
Vici syndrome (VICIS) is a rare, autosomal recessive neurodevelopmental disorder with multisystem involvement characterized by agenesis of the corpus callosum, cataracts, cardiomyopathy, combined immunodeficiency, developmental delay, and hypopigmentation. Mutations in EPG5, gene that encodes key autophagy regulator, have been shown to cause VICIS, however, precise pathomechanism underlying VICIS yet be clarified. Here, we describe detailed clinical (including brain MRI muscle biopsy)...
Joubert syndrome (JS) is rare recessive disorders characterized by the combination of hypoplasia/aplasia cerebellar vermis, thickened and elongated superior peduncles, a deep interpeduncular fossa which defined neuroimaging termed 'molar tooth sign'. JS genetically highly heterogeneous, with at least 29 disease genes being involved. To further understand genetic causes JS, we performed whole-exome sequencing in 24 newly recruited families. Together six previously reported families,...
Abstract Objective To determine whether sirolimus, a mechanistic target of rapamycin (mTOR) inhibitor, reduces epileptic seizures associated with focal cortical dysplasia (FCD) type II. Methods Sixteen patients (aged 6–57 years) FCD II received sirolimus at an initial dose 1 or 2 mg/day based on body weight (FCDS‐01). In 15 patients, the was adjusted to achieve trough ranges 5–15 ng/mL, followed by 12‐week maintenance therapy period. The primary endpoint lower seizure frequency during...
In neuromyelitis optica (NMO), B-cell autoimmunity to aquaporin-4 (AQP4) has been shown be essential. However, the role of T cells remains ambiguous. Here, we first showed an increase in CD69+ activated PBMCs during NMO relapses. Next, T-cell responses AQP4 and myelin peptides were studied 12 NM0 patients, 10 multiple sclerosis (MS) patients healthy subjects (HS). Four hours after adding 1 28 overlapping peptides, a mixture (AQP4-M) or one six distinct 2-day cultured PBMC, CD69 expression on...
Rett syndrome is a rare neurodevelopmental disorder caused by mutations in the MECP2 gene on X chromosome, primarily affecting females. It characterized developmental regression, stereotypic hand movements, seizures, and microcephaly due to decelerated head growth. However, atypical presentations, such as macrocephaly hyperostosis frontalis interna (HFI), are rarely reported. HFI, defined abnormal thickening of frontal bone, uncommon pediatric populations often linked metabolic disturbances,...
Summary: Purpose: To determine whether magnetoencephalography (MEG) has any clinical value for the analysis of seizure discharges in patients with medial frontal lobe epilepsy (FLE). Methods: Four were studied 74‐channel MEG. Interictal and ictal electroencephalographic (EEG) MEG recordings obtained. The equivalent current dipoles (ECDs) spikes calculated. Results: In two postural seizures, interictal EEG occurred at Cz or Fz. ECDs localized around supplementary motor area. other focal...
To examine whether magnetoencephalography (MEG) can be used to determine patterns of brain activity underlying widespread paroxysms epilepsy patients, thereby extending the applicability MEG a larger population patients.We studied two children with symptomatic localization-related epilepsy. Case 1 had spikes in EEG an operation scar from resection tumor; 2 hemispheric slow-wave sensory auras. was collected 204-channel helmet-shaped sensor array. Dynamic statistical parametric maps (dSPMs)...