A5067943705- Systemic Sclerosis and Related Diseases
- Wound Healing and Treatments
- Dermatologic Treatments and Research
- Inflammatory Myopathies and Dermatomyositis
- Dermatology and Skin Diseases
- Pressure Ulcer Prevention and Management
- Autophagy in Disease and Therapy
- Skin Diseases and Diabetes
- Eosinophilic Disorders and Syndromes
- Burn Injury Management and Outcomes
- Retinal and Macular Surgery
- Psoriasis: Treatment and Pathogenesis
- Connective Tissue Growth Factor Research
- Urological Disorders and Treatments
- Mesenchymal stem cell research
- Urologic and reproductive health conditions
- Gas Dynamics and Kinetic Theory
- Computational Fluid Dynamics and Aerodynamics
- Histiocytic Disorders and Treatments
- Retinal Diseases and Treatments
- Genomics, phytochemicals, and oxidative stress
- Botulinum Toxin and Related Neurological Disorders
- Environmental Toxicology and Ecotoxicology
- Hedgehog Signaling Pathway Studies
- Phagocytosis and Immune Regulation
Gunma University Hospital
2024
Gunma University
1982-2023
The University of Tokyo
1992-2003
Tokyo University of Agriculture
1995
Dokkyo University
1992
Cutaneous ischemia-reperfusion (I/R) injury is associated with the early pathogenesis of cutaneous pressure ulcers (PUs). The objective this study was to investigate effect mesenchymal stem cells (MSCs) injection on formation PUs after I/R and determine underlying mechanisms. We found that subcutaneous MSCs into areas injured skin significantly suppressed PUs. I/R-induced vascular damage, hypoxia, oxidative DNA apoptosis were decreased by injection. Oxidative stress signals detected in OKD48...
Abstract Several studies have demonstrated potential roles for apelin/APJ signaling in the regulation of oxidative stress associated with ischemia-reperfusion (I/R) injury several organs. Objective was to assess role development pressure ulcers (PUs) formation after cutaneous I/R mice. We identified that increased expression apelin skin at site. Administration significantly inhibited PUs. The reductions blood vessels, hypoxic area and apoptosis site were by injection. Oxidative signals OKD48...
Abstract Background Autoimmune pulmonary alveolar proteinosis (APAP) is a diffuse lung disease that causes abnormal accumulation of lipoproteins in the alveoli; however, its pathogenesis remains unclear. Recently, APAP cases have been reported during course dermatomyositis. The combination these two diseases may be coincidental; it overlooked because differentiating from flare-up interstitial pneumonia associated with dermatomyositis challenging. This didactic case demonstrates need for...
Ischemia-reperfusion (I/R) is associated with various pathogenic conditions, and there has been increasing evidence that cutaneous I/R injury the pathogenesis of pressure ulcers (PUs), especially at early stage presenting as non-blanchable erythema. Several studies demonstrated oxidative stress a key player in injury, inhibition may be capable protecting tissue damage after organs including skin. Dimethyl fumarate (DMF) approved by Food Drug Administration Nrf2 activator, recent revealed...
Objective Several studies have demonstrated that the secreted glycoprotein and integrin ligand milk fat globule–associated protein with epidermal growth factor– factor VIII–like domains (MFG‐E8) negatively regulates fibrosis in liver, lungs, respiratory tract. However, mechanisms roles of MFG‐E8 skin systemic sclerosis (SSc) not been characterized. We undertook this study to elucidate role SSc. Methods assessed expression serum SSc patients. examined effect recombinant (rMFG‐E8) on latent...
Abstract Dermatomyositis (DM) patients are known to have various infectious complications, such as cytomegalovirus (CMV) reactivation, due immune dysfunction caused by DM itself and immunosuppressants used for treatment. Although CMV reactivation has been be a major cause of mortality in immunocompromised hosts, there not sufficient study patients. The objective this was examine the frequency investigate risk factors potentially associated with development reactivation. We analyzed 52...
Abstract Oxidative stress has been reported to play an important role in the pathogenesis of skin fibrosis systemic sclerosis (SSc). We previously identified that botulinum toxin (BTX) injection suppresses pressure ulcer formation a cutaneous ischemia–reperfusion injury mouse model by regulation oxidative stress. However, therapeutic possibility BTX administration for preventing SSc is unclear. The objective this study was investigate effect BTX‐B on murine and determine underlying...
The nitrous oxide reductase from the photodenitrifier, Rhodobacter sphaeroides f. sp. denitrificans IL106, has been purified under anaerobic conditions. specific activity of enzyme was 78 μmol reduced per min mg protein, which approximately 80% higher than that aerobic form. anaerobically retained most its after storage at 4°C for 2 months without any additives. Visible absorption spectra resembled those enzymes other origins. reduction with sodium dithionite, and could be determined using...
Abstract Patients with systemic sclerosis (SSc) develop various vasculopathy‐induced vascular disorders such as Raynaud’s phenomenon, abnormal nail‐fold capillaries, persistent digital ischemia, ulcers (DU), and sometimes renal crisis pulmonary artery hypertension (PAH), affecting prognosis. Earlobe crease (ELC), also known Frank’s sign, is a wrinkle extending from the tragus to outer border of earlobe generally recognized sign cardiovascular events. However, no previous study analyzed...