Yonehiro Kanemura
A5010885703- Glioma Diagnosis and Treatment
- Pluripotent Stem Cells Research
- Radiomics and Machine Learning in Medical Imaging
- Neurogenesis and neuroplasticity mechanisms
- Brain Metastases and Treatment
- Hedgehog Signaling Pathway Studies
- Fetal and Pediatric Neurological Disorders
- Meningioma and schwannoma management
- Medical Imaging Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Mesenchymal stem cell research
- Genetics and Neurodevelopmental Disorders
- Brain Tumor Detection and Classification
- Cerebrospinal fluid and hydrocephalus
- Microtubule and mitosis dynamics
- Cancer, Hypoxia, and Metabolism
- 3D Printing in Biomedical Research
- Neuroblastoma Research and Treatments
- Biomedical Ethics and Regulation
- MRI in cancer diagnosis
- MicroRNA in disease regulation
- Advanced MRI Techniques and Applications
- Tissue Engineering and Regenerative Medicine
- Cancer Cells and Metastasis
Osaka National Hospital
2016-2025
Asahikawa Medical University
2025
Japanese Society of Medical Oncology
2024
Yamagata University Hospital
2023
Osaka International Cancer Institute
2019-2023
Stony Brook University
2022
Neurological Surgery
1996-2022
Shinshu University
2022
Foundation for Biomedical Research and Innovation
2021
Hyogo Medical University
2020
Recent studies have shown that delayed transplantation of neural stem/progenitor cells (NSPCs) into the injured spinal cord can promote functional recovery in adult rats. Preclinical using nonhuman primates, however, are necessary before NSPCs be used clinical trials to treat human patients with injury (SCI). Cervical contusion SCIs were induced 10 common marmosets a stereotaxic device. Nine days after injury, vitro-expanded transplanted five randomly selected animals, and other...
Multiple independent genomic profiling efforts have recently identified clinically and molecularly distinct subgroups of ependymoma arising from all three anatomic compartments the central nervous system (supratentorial brain, posterior fossa, spinal cord). These advances motivated a consensus meeting to discuss: (1) utility current histologic grading criteria, (2) integration molecular-based stratification schemes in future clinical trials for patients with (3) therapy context molecular...
The prognostic impact of TERT mutations has been controversial in IDH-wild tumors, particularly glioblastomas (GBM). controversy may be attributable to presence potential confounding factors such as MGMT methylation status or patients' treatment. This study aimed evaluate the on patient outcome association with various a large series adult diffuse gliomas. We analyzed total 951 gliomas from two cohorts (Cohort 1, n = 758; Cohort 2, 193) for IDH1/2, 1p/19q, and promoter status. combined...
Our group has conducted extensive basic and preclinical studies of the use human induced pluripotent cell (iPSC)-derived neural stem/progenitor (hiPSC-NS/PC) grafts in models spinal cord injury (SCI). Evidence from animal experiments suggests this approach is safe effective. We are preparing to initiate a first-in-human clinical study hiPSC-NS/PC transplantation subacute SCI.NS/PCs were prepared at Good Manufacturing Practice-grade processing facility Osaka National Hospital using...
Abstract Transplantation of human neural stem cells (NSCs) is a promising potential therapy for neurologic dysfunctions after the hyperacute stage stroke in humans, but large amounts NSCs must be expanded long‐term culture such therapy. To determine their possible therapeutic stroke, fetal stem/progenitor (NSPCs) (i.e., neurosphere‐forming cells) were isolated originally from forebrain tissues one fetus, and neurosphere (exceeding 24 weeks), then xenografted into lesioned areas brains...
We integrated clinical, histopathological, and molecular data of central nervous system germ cell tumors to provide insights into their management.Data from the Intracranial Germ Cell Tumor Genome Analysis (iGCT) Consortium were reviewed. A total 190 cases classified as primary (GCTs) based on pathological reviews.All but one that bifocal (neurohypophysis pineal glands) with multiple lesions including neurohypophysis or gland germinomas (34 35). Age was significantly higher in patients...
Abstract Molecular biological characterization of tumors has become a pivotal procedure for glioma patient care. The aim this study is to build conventional MRI-based radiomics model predict genetic alterations within grade II/III gliomas attempting implement lesion location information in the improve diagnostic accuracy. One-hundred and ninety-nine patients were enrolled. Three molecular subtypes identified: IDH1/2 -mutant, -mutant with TERT promoter mutation, IDH- wild type. A total 109...
Extensive molecular analyses of ependymal tumors have revealed that supratentorial and posterior fossa ependymomas distinct profiles are likely to be different diseases. The presence C11orf95-RELA fusion genes in a subset (ST-EPN) indicated the existence subgroups. However, pathogenesis RELA fusion-negative remains elusive. To investigate these validate classification tumors, we conducted thorough 113 locally diagnosed from 107 patients Japan Pediatric Molecular Neuro-Oncology Group. All...
Abstract To scale up human neural stem/progenitor cell (NSPC) cultures for clinical use, we need to know how long these cells can live ex vivo without losing their ability proliferate and differentiate; thus, a convenient method is needed estimate the proliferative activity of NSPCs grown in neurosphere cultures, as direct counting laborious potentially inaccurate. Here, isolated from fetal forebrain prepared cultures. We determined number viable estimated long‐term culture using two methods...
Abstract Neural stem/progenitor cells (NSPCs) proliferate as aggregates in vitro, but the mechanism of aggregation is not fully understood. Here, we report that promotes proliferation NSPCs. We found rate was linear and depended on size aggregate; is, population doubling time NSPCs gradually decreased diameter approached 250 μm flattened to a nearly constant value beyond this diameter. Given finding, with intent enhancing efficiency human NSPC expansion, induced form close quickly by...
In a previous study, we showed that murine dendritic cells (DCs) can increase the number of neural stem/progenitor (NSPCs) in vitro and vivo. present identified macrophage migration inhibitory factor (MIF) as novel support proliferation and/or survival NSPCs vitro. MIF is secreted by DCs NSPCs, its function normal brain remains largely unknown. It was previously shown macrophages, binds to CD74-CD44 complex. Here, observed expression receptors mouse ganglionic eminence (GE)-derived...
Abstract We attempted to establish a magnetic resonance imaging (MRI)-based radiomic model for stratifying prognostic subgroups of newly diagnosed glioblastoma (GBM) patients and predicting O (6)-methylguanine-DNA methyltransferase promotor methylation ( pMGMT -met) status the tumor. Preoperative MRI scans from 201 GBM were included in this study. A total 489 texture features including first-order feature, second-order 162 datasets, location data 182 datasets collected. Supervised principal...
Abstract Identification of genotypes is crucial for treatment glioma. Here, we developed a method to predict tumor using pretrained convolutional neural network (CNN) from magnetic resonance (MR) images and compared the accuracy that diagnosis based on conventional radiomic features patient age. Multisite preoperative MR 164 patients with grade II/III glioma were grouped by IDH TERT promoter (pTERT) mutations as follows: (1) wild type, (2) pTERT co-mutations, (3) mutant type. We applied CNN...
Delayed transplantation of neural stem/progenitor cells (NS/PCs) into the injured spinal cord can promote functional recovery in adult rats and monkeys. To enhance after NS/PC transplantation, we focused on galectin-1, a carbohydrate-binding protein with pleiotropic roles cell growth, differentiation, apoptosis, neurite outgrowth. Here, to determine combined therapeutic effect galectin-1 injury (SCI), human NS/PCs were transfected by lentivirus green fluorescent (GFP), (Gal-NS/PCs) or GFP...
18F-fluciclovine (trans-1-amino-3-[18F] fluorocyclobutanecarboxylic acid, [FACBC]) is an artificial amino acid radiotracer used for positron emission tomography (PET) studies, which metabolically stable in vivo and has a long half-life. It already been shown that FACBC-PET useful glioma imaging. However, there have no reports evaluating the efficiency of diagnosis brain tumors comparison with other PET tracers clinical studies. The purpose this study was to investigate efficacy imaging...