A5090411944- Antenna Design and Analysis
- Antenna Design and Optimization
- Advanced Antenna and Metasurface Technologies
- Electromagnetic Compatibility and Measurements
- Cardiac Valve Diseases and Treatments
- Metal complexes synthesis and properties
- Microwave Engineering and Waveguides
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Reproductive Biology and Fertility
- Microwave Imaging and Scattering Analysis
- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- Millimeter-Wave Propagation and Modeling
- Antimicrobial Resistance in Staphylococcus
- Magnetism in coordination complexes
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Indoor and Outdoor Localization Technologies
- Cardiac Arrhythmias and Treatments
- Advanced MIMO Systems Optimization
- Sperm and Testicular Function
- Advanced SAR Imaging Techniques
- Cellular and Composite Structures
- Engineering Applied Research
Hokkaido Institute of Public Health
2021-2024
Keio University
2016-2024
SoftBank Group (Japan)
2015-2024
Toyohashi Heart Center
2019-2024
Nihon University
2024
National Center for Geriatrics and Gerontology
2022-2024
Isesaki Municipal Hospital
2022-2024
Shinshu University
2023-2024
Osaka Institute of Technology
2023-2024
University of Tsukuba
2003-2024
Our group has conducted extensive basic and preclinical studies of the use human induced pluripotent cell (iPSC)-derived neural stem/progenitor (hiPSC-NS/PC) grafts in models spinal cord injury (SCI). Evidence from animal experiments suggests this approach is safe effective. We are preparing to initiate a first-in-human clinical study hiPSC-NS/PC transplantation subacute SCI.NS/PCs were prepared at Good Manufacturing Practice-grade processing facility Osaka National Hospital using...
Sperm from four different gene-disrupted mouse lines (calmegin [Clgn], Adam1a, Adam2, and Ace) are known to have defective zona-binding ability. Moreover, it is also reported that the sperm all of these exhibit another common phenotype impaired migration into oviduct despite large number found in uterus after coitus. On other hand, Adam3-disrupted line was defects binding ability zona, but were able move oviduct. In order clarify difference, we investigated ADAM3-null precisely by...
Local control of sperm maturation Newly produced spermatozoa within the testis do not have fertilizing ability but become fully functional when they mature in epididymis. The development epididymis itself is dependent on testicular factors arriving via luminal flow. Improper signaling between and hypothesized to result male infertility. Kiyozumi et al. identified NELL2 as a protein that binds its receptor, ROS1, surface induces epididymal differentiation (see Perspective by Lord Oatley). In...
Streptococcus pyogenes causes mild human infections as well life-threatening invasive diseases. Since the mutations known to enhance virulence date account for only half of severe infections, additional mechanisms/mutations need be identified. Here, we conducted a genome-wide association study emm 89 S. strains comprehensively identify pathology-related bacterial genetic factors (SNPs, indels, genes, or k-mers). Japanese ( n =311) and global =666) cohort studies isolated from non-invasive...
Male mice deficient for the calmegin (Clgn) or angiotensin-converting enzyme (Ace) gene show impaired sperm migration into oviduct and loss of sperm-zona pellucida binding ability in vitro. Since CLGN is a molecular chaperone membrane transport target proteins ACE protein, we looked on membranes from Clgn-/- mice. was present showed normal activity, indicating that not involved transporting to membranes. The ablation Adam2 Adam3 genes generated animals whose did bind zona pellucida, which...
Importance Loneliness is suggested to negatively affect physical and mental health influence the development of disability; however, a consensus on relationship between loneliness disability has not been reached. Age-related hearing impairment worsens daily-life activities older adults, association incidence may be influenced by impairment. Objective To examine among adults stratified Design, Setting, Participants This prospective observational cohort study included 5563 community-dwelling...
Cognitive reserve (CR) is a property of the brain that allows for better-than-expected cognitive performance relative to degree change over course life. However, neurophysiological markers CR remain under-investigated. Electroencephalography (EEG) features may function as suitable CR. To assess this, we investigated whether dorsal attention network (DAN) and ventral (VAN) activities, measured during resting-state EEG, moderate relationship between hippocampal volume episodic memory.
A palmitate linked to the inositol in glycosylphosphatidylinositol (GPI) is removed endoplasmic reticulum immediately after conjugation of GPI with proteins most cells. Previously, we identified PGAP1 (post attachment 1) as a inositoldeacylase that removes from inositol. defect caused delay transport GPI-anchored (GPI-APs) cell surface Chinese hamster ovary cells, although cell-surface expression GPI-APs steady state was normal. Nevertheless, undergo deacylation. To elucidate biological...
Incorporation of an azobenzene core into tethered bis(trityl alcohol) allows the photoswitchable arrangement two trityl alcohol units through photoisomerization azobenzene. The differently arranged change their cooperative function to reflect positional relationships, and thus, activity as a acid can be controlled by light stimuli (see figure). Detailed facts importance specialist readers are published "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset....
Regular physical activity throughout life is generally recommended to prevent dementia; however, there little evidence regarding the association between lifetime and mild cognitive impairment (MCI), which often precedes dementia. This study aimed examine of their transitions with late-life MCI.
Abstract Seismic waveforms, including teleseismic body waves, contain information about the irregular behavior of rupture propagation, which is essential for understanding evolution process large earthquakes. Here, a high-degree-of-freedom source inversion applied to P waves 2023 moment magnitude 6.8 Morocco earthquake reveal during growth. The resulting total tensor solution an oblique focal mechanism that exhibits reverse faulting with strike-slip component. There are two distinct peaks at...
Streptococcus pyogenes causes mild human infections as well life-threatening invasive diseases. Since the mutations known to enhance virulence date account for only half of severe infections, additional mechanisms/mutations need be identified. Here, we conducted a genome-wide association study emm 89 S. strains comprehensively identify pathology-related bacterial genetic factors (SNPs, indels, genes, or k-mers). Japanese ( n =311) and global =666) cohort studies isolated from non-invasive...
On August 21, 2021 a large earthquake occurred in the South Sandwich subduction zone, and associated tsunami was widely observed. In order to robustly analyse detailed seismic source process of this long-source duration (over 200 s) event occurring convexly shaped we applied Potency Density Tensor Inversion with non-rectangular non-planar surface broadband teleseismic P-waves. This method allows us suitably reduce effect time-increasing uncertainty Green’s function modelling errors related...
Loss of calmegin, a testis-specific putative chaperone protein the endoplasmic reticulum, leads to male sterility because sperm show defects in migration into oviduct and do not bind zona pellucida. To clarify mechanism defective migration, XY ⟷ chimeras were produced by aggregating wild-type embryos with transgenic mice lacking functional calmegin genes expressing enhanced green fluorescent (EGFP) their acrosomes. Chimeric ejaculates contained wild-type, nonfluorescent as well EGFP-tagged...
We have developed a spectroscopic optical coherence tomography (OCT) for imaging lipid distribution within blood vessel in order to detect coronary artery plaque. A 1.7-μm spectral-domain OCT with A-scan rate of 47 kHz is fabricated using broadband light source based on super-luminescent diodes and spectrometers extended InGaAs line sensors. demonstrate an vitro model lipid. The sensitivity specificity the differentiation between are 87% 90% training, respectively. validation test also shows...
Configuration confirmed: The first total synthesis and structure assignment of the anthrone C-glycoside cassialoin (1) have been achieved by exploiting an isoxazole-containing stereogenic α-ketol a subsequent intramolecular redox reaction (see retrosynthetic analysis; MOM = methoxymethyl).
Eight kinds of gene-disrupted mice (Clgn, Calr3, Pdilt, Tpst2, Ace, Adam1a, Adam2, and Adam3) show impaired sperm transition into the oviducts defective binding to zona pellucida. All these knockout strains are reported lack or aberrant expression a disintegrin metallopeptidase domain 3 (ADAM3) on membrane. We performed proteomic analyses proteins infertile spermatozoa clarify whether abnormal function is caused exclusively by deficiency in ADAM3 expression. Two proteins, named PMIS1 PMIS2,...
We developed a transplantable tissue-engineered skin equivalent composed of autologous cultured keratinocytes, fibroblasts, and decellularized allogeneic dermis (acellular dermal matrix; ADM) obtained from cadavers. In process taking 3 weeks, keratinocytes burn patients were expanded then grown on ADMs. The equivalents (TESEs) transplanted in one-stage procedure to the debrided third-degree wounds 4 patients. mean graft survival rate was 96%. Delayed loss fragility not observed. Histological...
This study sought to systematically evaluate the ability of a high-resolution mapping system (Rhythmia, Boston Scientific, Marlborough, Massachusetts) rapidly and accurately localize residual endocardial epicardial conduction after mitral isthmus (MI) ablation, facilitating MI block. Achieving block across is challenging. Fifty consecutive patients undergoing ablation pulmonary vein isolation were enrolled. After initial radiofrequency (RF) lateral MI, activation with simultaneous coronary...
Tissue-engineered skin equivalents composed of epidermal and dermal components have been widely investigated for coverage full-thickness defects. We developed a tissue-engineered oral mucosa equivalent based on an acellular allogeneic matrix its characteristics. also tried assessed preliminary clinical application. Human mucosal keratinocytes were separated from piece cultured in chemically-defined medium. The seeded to the cultured. Histologically, had well-stratified epithelial layer....
CD52 is a glycosylphosphatidylinositol (GPI)‐anchored antigen expressed on lymphocytes and in epididymal epithelial cells. also known as “maturation‐associated sperm antigen” but its function unknown. We therefore generated Cd52 disrupted mice. The resulting null mice were healthy, even though cells of the immune system. then examined possible role for reproduction. Sperm from ‐deficient males investigated viability, motility, morphology, incidence spontaneous acrosome reactions found to be...