A5047487286- Health disparities and outcomes
- Frailty in Older Adults
- Dementia and Cognitive Impairment Research
- Nutrition and Health in Aging
- Plant Physiology and Cultivation Studies
- EEG and Brain-Computer Interfaces
- Technology Use by Older Adults
- Esophageal and GI Pathology
- Postharvest Quality and Shelf Life Management
- Physical Activity and Health
- Fermentation and Sensory Analysis
- Nutritional Studies and Diet
- Cardiac Ischemia and Reperfusion
- Urban Transport and Accessibility
- Phytochemicals and Antioxidant Activities
- Older Adults Driving Studies
- Body Composition Measurement Techniques
- Congenital Heart Disease Studies
- Horticultural and Viticultural Research
- Geriatric Care and Nursing Homes
- Gastrointestinal disorders and treatments
- Foreign Body Medical Cases
- Musculoskeletal pain and rehabilitation
- Health Systems, Economic Evaluations, Quality of Life
- Muscle activation and electromyography studies
National Center for Geriatrics and Gerontology
2020-2025
Japan Society for the Promotion of Science
2021-2024
Columbia University Irving Medical Center
2024
Kyoto Tachibana University
2019-2024
Columbia University
2023-2024
Community Living
2024
Kio University
2015-2019
Sakurabashi Watanabe Hospital
2015-2019
Nitto (Japan)
2009
Kobe University
1991-2002
Importance Loneliness is suggested to negatively affect physical and mental health influence the development of disability; however, a consensus on relationship between loneliness disability has not been reached. Age-related hearing impairment worsens daily-life activities older adults, association incidence may be influenced by impairment. Objective To examine among adults stratified Design, Setting, Participants This prospective observational cohort study included 5563 community-dwelling...
Cognitive reserve (CR) is a property of the brain that allows for better-than-expected cognitive performance relative to degree change over course life. However, neurophysiological markers CR remain under-investigated. Electroencephalography (EEG) features may function as suitable CR. To assess this, we investigated whether dorsal attention network (DAN) and ventral (VAN) activities, measured during resting-state EEG, moderate relationship between hippocampal volume episodic memory.
The metabolism of 20:4 (arachidonic acid) in alkenylacyl, alkylacyl and diacyl lipid classes choline glycerophospholipids (CGP) ethanolamine (EGP) rabbit alveolar macrophages was examined. [3H]20:4 very rapidly incorporated into glycerophosphocholine (GPC). After the removal free 20:4, radioactivity gradually lost from GPC. Concomitantly, radioactivities GPC alkenylacyl glycerophosphoethanolamine (GPE) were increased, indicating that mobilized to GPE. mobilization considered be a...
Regular physical activity throughout life is generally recommended to prevent dementia; however, there little evidence regarding the association between lifetime and mild cognitive impairment (MCI), which often precedes dementia. This study aimed examine of their transitions with late-life MCI.
Aim Fatigue is a common health problem in older adults. Chronic pain associated with fatigue. However, the longitudinal association between chronic and incidence of subjective fatigue among community‐dwelling adults remains unclear. Therefore, this study aimed to investigate using prospective data. Methods The included 2060 (age 70.5 ± 6.4 years; male: n = 944) without at baseline. other data were assessed Subjective was investigated follow‐up examination 2.5 years from Results In total, 389...
Abstract INTRODUCTION Low cognitive function and poor health literacy are risk factors for dementia have a bidirectional relationship. Here, we examined their individual combined effects on the incidence of dementia. METHODS This longitudinal study included 2445 community‐dwelling Japanese older adults aged ≥ 65 years without at baseline. We assessed participants’ baseline using multidomain neurocognitive test Communicative Critical Health Literacy Scale, respectively. Participants were...
Background/Objectives: This study evaluated the effects of a tactile-discrimination compensatory real-time feedback device on hand sensorimotor function in cervical spinal cord injury patients. The assessed changes numbness, dexterity, and electroencephalogram (EEG) activity, particularly γ-wave power area during skilled finger movements. Methods: Three patients with who presented dysfunction underwent treatment this device. All cases intervention using an AB design; A is exercise task...
The present study aimed to examine the prospective associations of physical frailty with future falls and fear falling (FOF) among community-dwelling older adults.A cohort a 48-month follow-up was conducted in Japanese community. Participants were 2469 adults aged 65 years or who completed baseline assessments at intervals 48 ± 2 months. Primary outcomes recent (defined as least one fall within past year) FOF (determined by response "Are you afraid falling?") survey. Physical frailty,...
Physical frailty is associated with social activity. However, the relationship between physical and levels of engagement other people during activities remains unclear. Thus, we aimed to clarify activity using a taxonomy among community-dwelling older adults in Japan.This cross-sectional observational study analyzed data from 12,788 (7001 women, mean age: 73.8 years, standard deviation = 5.9; range: 60-96 years) National Center for Geriatrics Gerontology-Study Geriatric Syndromes. was...
Study objective – The aim of the study was to investigate effect reperfusion with adenosine after prolonged cardioplegic arrest in isolated working rat heart. Design After 3 h hypothermic (20°C) ischaemic multidose (every 30 min) infusions St Thomas's Hospital soluton No 1, hearts were reperfused either ordinary perfusion fluid (Krebs-Henseleit bicarbonate buffer) or additional (1 mg·litre−1) for 15 min prior assessing recovery function. Experimental material Hearts (n=10 each group)...
The present study developed a simplified decision-tree algorithm for fall prediction with easily measurable predictors using data from longitudinal cohort study: 2520 community-dwelling older adults aged 65 years or participated. Fall history, age, sex, fear of falling, prescribed medication, knee osteoarthritis, lower limb pain, gait speed, and timed up go test were assessed in the baseline survey as predictors. Moreover, recent falls follow-up survey. We created fall-prediction analysis...
Seven healthy volunteers and 3 hospitalized patients were given the same diet for 6 days. The mean intake of cholesterol was 359 mg/day. There a large difference in fecal amount coprostanol amongthe subjects. ratio coprostanol/cholesterol ranged from 0.01 to 4.27. subjects whose feces contained smaller amountof excreted larger amounts β-sitosterol crude fiber, suggesting that various activities intestinal flora lower than other subjects.The activity convert into ascertained by incubating...
Nearly half of older adults with frailty experience chronic pain. Chronic pain contributes to activity restrictions. Decreased physical is associated not only dysfunction but also reduced engagement in social activities. We aimed verify the hypothesis that and decreased are incidence.
This study clarified the patterns of possessing modifiable risk factors dementia that can be corrected by elderly who were primarily determined to have mild cognitive impairment (MCI), and then relationship between retention outcomes from MCI through a 4-year follow-up study. The participants 789 community-dwelling elders ≥65 years old with at baseline. After 4 years, classified into reverters nonreverters, according their function. Repeated measures analysis was performed after imputing...
The aim of this study was to examine the association between lifestyle activities, including physical, cognitive, and social Alzheimer's disease (AD) signature cortical thickness, as well mediating role AD thickness in activities cognitive function community-dwelling healthy older adults. Participants were 1026 adults who met inclusion criteria. daily life assessed using a self-reporting questionnaire. determined FreeSurfer software. Cognitive evaluated National Center for Geriatrics...