A5101664367- Shoulder Injury and Treatment
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Shoulder and Clavicle Injuries
- Cerebral Palsy and Movement Disorders
- Glioma Diagnosis and Treatment
- Occupational Therapy Practice and Research
- Orthopedic Surgery and Rehabilitation
- Meningioma and schwannoma management
- Bone fractures and treatments
- Elbow and Forearm Trauma Treatment
- Hip and Femur Fractures
- Peripheral Nerve Disorders
- Ultrasound and Hyperthermia Applications
- Neurogenesis and neuroplasticity mechanisms
- Delphi Technique in Research
- Hip disorders and treatments
- Orthopedic Infections and Treatments
- Spine and Intervertebral Disc Pathology
- Medical Imaging Techniques and Applications
- Head and Neck Surgical Oncology
- Botulinum Toxin and Related Neurological Disorders
- Functional Brain Connectivity Studies
- Radiation Dose and Imaging
- Spatial Neglect and Hemispheric Dysfunction
Fujita Health University
2013-2024
Fukushima Medical University
2013-2024
Laboratory of Racing Chemistry
2008-2024
Niigata Institute of Technology
2014-2015
Fujita Health University Hospital
2000-2015
Kanagawa Institute of Technology
2015
Kyushu University
2014
Central Institute for Experimental Animals
2006-2010
Hitachi Maxell (Japan)
2010
Keio University Hospital
2008
In the adult brain, neuroblasts born in subventricular zone migrate from walls of lateral ventricles to olfactory bulb. How do these cells orient over such a long distance and through complex territories? Here we show that neuroblast migration parallels cerebrospinal fluid (CSF) flow. Beating ependymal cilia is required for normal CSF flow, concentration gradient formation guidance molecules, directional neuroblasts. Results suggest polarized epithelial contribute important vectorial...
Delayed transplantation of neural stem/progenitor cells (NS/PCs) into the injured spinal cord can promote functional recovery in adult rats and monkeys. To enhance after NS/PC transplantation, we focused on galectin-1, a carbohydrate-binding protein with pleiotropic roles cell growth, differentiation, apoptosis, neurite outgrowth. Here, to determine combined therapeutic effect galectin-1 injury (SCI), human NS/PCs were transfected by lentivirus green fluorescent (GFP), (Gal-NS/PCs) or GFP...
The adult subventricular zone (SVZ) of the lateral ventricle contains neural stem cells. In rodents, these cells generate neuroblasts that migrate as chains toward olfactory bulb along rostral migratory stream (RMS). neural-stem-cell niche at ventricular wall is conserved in various animal species, including primates. However, it unclear how SVZ and RMS organization nonhuman primates relates to rodents humans. Here we studied neonatal common marmoset (Callithrix jacchus), a New World primate...
Purpose To investigate the use of diffusion-tensor imaging (DTI) to detect denervation nigrostriatal pathway in a nonhuman primate model Parkinson disease (PD) after treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Materials and Methods This study was approved by institutional committee for animal experiments. DTI performed marmosets (n = 6) using 7-T magnetic resonance (MR) imager before 10 weeks administration MPTP. Fixed brains normal marmoset PD 1) were analyzed...
Abstract Allodynia, a form of neuropathic pain, is defined as pain in response to non-nociceptive stimulus. The brain regions responsible for which are not normally activated, can be activated allodynic mice by providing suitable stimulus Aβ-fibers, transmit signals from tactile sensory fibers. Functional MRI (fMRI) used objectively observe abnormal activation. In the present study, fMRI was conducted investigate allodynia mice; generated surgical injury at L4 spinal nerve root, thus...
医薬品副作用データベース(英名: Japanese Adverse Drug Event Report database,略称; JADER)が,2012年4月に公開され,医薬品の適正使用情報としての活用が期待されている.本論文では,副作用発現時期の新たな評価方法として,副作用発現日を Weibull 分布にあてはめて推定した形状パラメータによる発現時期プロファイルの分析を取り上げ,自殺関連または糖尿病関連副作用のインターフェロン製剤間の違いを検討した.2013年8月の JADER から重複を除いた薬剤と副作用の組合せ件数 702,925 件のデータを用いた.自殺関連または糖尿病関連副作用は,PRR 等でシグナルと判断された.糖尿病関連副作用は,製剤間で副作用発現時期の分布が異なり,Weibull 分布の形状パラメータは,α 製剤では1.49(1.09-1.94)(点推定値および両側 95%信頼区間)と下側 95%信頼区間が有意に 1 を超え,摩耗故障型副作用時期プロファイルが示唆された.β 製剤では 0.84(0.66-1.05)と上側 95%信頼区間が...
Vadadustat is a newly launched hypoxia-inducible factor stabilizer with anti-anemia and erythropoietic effects; however, its use in horses expressly forbidden both racing equestrian competitions. Following our previous report on the pharmacokinetic study of vadadustat horse plasma urine, long-term longitudinal analysis hair after nasoesophageal administration (3 g/day for 3 days) to three thoroughbred mares described this study. Our main objective further extend detection period purpose...
固相抽出法は，高速液体クロマトグラフィー（HPLC），ガスクロマトグラフィー（GC）などの有機化合物の機器分析における前処理法として，試料マトリックスからの目的化合物の分離濃縮法として利用されてきた．近年，金属イオンに選択性のある分離剤を利用した固相抽出法により，無機分析においても高感度化，金属の形態別分離分析が広く検討されるようになった．無機分離剤には，イオン交換樹脂，キレート樹脂が広く固相抽出法の分離剤として利用されている．近年では，クラウンエーテルに代表される大環状官能基を導入した高選択性樹脂の事例が報告されるようになり，誘導結合プラズマ（ICP）発光分析における分光干渉の緩和などに応用されている．本論文では，近年応用事例の報告が著しい，無機分析のための固相抽出法について，分離剤の種類と特長を基礎事項として体系立てて論ずる．また，近年の報告事例を引用しながら，環境水中の微量元素群を濃縮しICP発光分析や原子吸光光度法により検出する手法，高マトリックスの産業試料中から目的元素を選択的に分離検出する手法，土壌中の微量元素を分離分析する手法について論ずる．
[Purpose] The aim of this study was to examine the applicability Objective Structured Clinical Examination (OSCE) postgraduate education systems for novice and mid-career therapists in workplaces. [Subjects] Physical occupational with 1 5 years clinical experience took OSCE assess their learning, a physical or therapy faculty member supervisor as examiners. Another acted simulated patient. [Methods] A Wilcoxon signed-rank test performed compare skills between before after OSCE-based...
[Purpose] To examine agreement rates between faculty members and clinical supervisors as OSCE examiners. [Subjects] The study subjects were involved physical occupational therapists working in environments for 1 to 5 years after graduating from training schools examinees, a or therapy member supervisor Another acted simulated patient. [Methods] rate the examiners each item was calculated based on Cohen's kappa coefficient confirm inter-rater reliability. [Results] behavioral aspects of items...
[Purpose] A major issue in physical/occupational therapist education is the improvement of students' clinical techniques. In this study, we introduced an system using Objective Structured Clinical Examination (OSCE), and made attempt at standardization its evaluation. [Subjects] The subjects were 227 students classes 2008 to 2010 who enrolled our university between 2004 2006, before introduction OSCE, 221 2011 2013 2007 2009, after introduction. [Methods] Performances attitude skills...
We conducted a feasibility study to investigate the therapeutic effect of bevacizumab on vestibular schwannomas (VS) associated with neurofibromatosis type 2 (NF2) in sample Japanese patients. Ten NF2 patients were selected between 2013 and 2018: nine women one man, ages ranging from 12 45 years (mean: 29.4). Bevacizumab was administered intravenously 5 mg/kg doses four times, an inter-dose interval weeks. Seventeen tumors followed for 3–72 months 39). A reduction baseline tumor volume at...
[Purpose] This study investigated the progress of standardization "clinical competencies evaluation with definition" in education physical therapists and occupational by searching for relevancies between performance Objective Structured Clinical Examination (OSCE), university practical training. [Subjects Methods] Subjects were 227 students who graduated 2007 2009, 174 2010 2011. For data analyses, comparisons among different timings training as well before after reform OSCE compliant system...
6価クロム｛Cr(VI)｝は，高周波誘導結合プラズマ発光分析法（ICP-AES）において直接分別定量することが困難であり，JIS K 0102，JIS H 8625，EPA3060Aなどの各種試験法においてジフェニルカルバジドによる発色後の吸光光度法が指定されている．ICP-AESを採用するには事前に6価クロムのみ分離してから導入する必要があり，従来陰イオン交換固相抽出が検討されてきたが，酸性条件や塩濃度が高い条件下での分離操作が煩雑であった．一方，ジフェニルカルバジド法における検出では，実試料が有機物や油分の影響により着色・白濁していることが想定され，正確な測定が困難になる場合がある．本研究では陰イオン交換樹脂と比較して6価クロムへの選択性が高い分子認識能のある高選択性樹脂を固相抽出カートリッジとして作製し，複数元素群からの選択分離の検証，最適抽出条件を検討した．本研究で確立した手法を実試料に適用したところ，白濁着色した工業廃液において89.2～96.2％，着色した土壌抽出液において88.5％ の良好な回収率が得られた．