A5089397194- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Neurobiology of Language and Bilingualism
- Advanced Neuroimaging Techniques and Applications
- Neurofibromatosis and Schwannoma Cases
- Vascular Malformations Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- Brain Metastases and Treatment
- Cerebrospinal fluid and hydrocephalus
- Pituitary Gland Disorders and Treatments
- Intraoperative Neuromonitoring and Anesthetic Effects
- Cancer, Hypoxia, and Metabolism
- Functional Brain Connectivity Studies
- Cerebrovascular and Carotid Artery Diseases
- Augmented Reality Applications
- Bone Tumor Diagnosis and Treatments
- RNA Interference and Gene Delivery
- Reconstructive Surgery and Microvascular Techniques
- Neuroblastoma Research and Treatments
- Surgical Simulation and Training
- Medical Imaging Techniques and Applications
- Pediatric Hepatobiliary Diseases and Treatments
- Moyamoya disease diagnosis and treatment
Fukushima Medical University
2010-2024
Hokkaido University
2020
The University of Texas Medical Branch at Galveston
2020
Nagoya University
2007-2016
Nagoya University Hospital
2004-2015
Nagoya City University
2015
Graduate School USA
2015
Osaka Medical Center for Cancer and Cardiovascular Diseases
2013
Yonsei University
2011
Okayama University
2007-2011
We explored susceptibility to injury after global ischemia in SV-129 and C57Black/6 mice, two commonly used-background strains genetically engineered mice.Mice (n = 84) were subjected 15, 30, or 75 minutes of bilateral common carotid artery (BCCA) occlusion followed by reperfusion for 72 hours. BCCA was performed under halothane chloral hydrate anesthesia, one experiment, mean arterial blood pressure regional cerebral flow (laser Doppler flowmetry) matched controlled exsanguination. Baseline...
The deep frontal pathway connecting the superior gyrus to Broca's area, recently named aslant tract (FAT), is assumed be associated with language functions, especially speech initiation and spontaneity. Injury lobe known cause aphasia that mimics caused by damage supplementary motor area. Although fiber dissection tractography have revealed existence of tract, little about its function. aim this study was determine function FAT via electrical stimulation in patients glioma who underwent...
The purpose of this study was to compare the analgesic effect pulsating ultrasound treatment and placebo on delayed onset muscle soreness produced by an eccentric exercise bout. In addition, pulsed muscular performance following bout studied. Eighteen untrained subjects were randomly assigned to: 1) (A) [N = 6] over areas concentrated soreness, i.e. proximal vastus lateralis distal medialis; 2) (B) 6]; 3) no therapeutic intervention (C) 6]. Baseline data recorded for maximum isometric knee...
To evaluate whether plasma high molecular weight (HMW) adiponectin provides prognostic information in addition to that obtained from clinical, haemodynamic, and biochemical variables previously known be associated with a mortality chronic heart failure (CHF) patients.We measured the levels of total HMW adiponectin, atrial natriuretic peptide, brain peptide (BNP), N-terminal-proBNP (NT-proBNP), haemodynamic parameters 449 consecutive CHF patients. Based on body mass index (BMI), patients were...
Transfer of interferon β gene via cationic liposomes has been found to induce regression experimental glioma. We performed a pilot clinical trial safety and effectiveness this therapy in five patients with malignant glioma (glioblastoma multiforme or anaplastic astrocytoma). Transgene expression antitumor activity were detected four patients. Two showed partial response (>50% tumor reduction) two others had stable disease 10 weeks after beginning therapy. One patient could not be evaluated...
Gliomas are the most frequently occurring primary brain tumor in central nervous system of adults. Glioblastoma multiformes (GBMs, WHO grade 4) have a dismal prognosis despite use alkylating agent, temozolomide (TMZ), and even low gliomas (LGGs, 2) eventually transform to malignant secondary GBMs. Although GBM patients benefit from promoter hypermethylation O(6)-methylguanine-DNA methyltransferase (MGMT) that is main determinant resistance TMZ, recent studies suggested MGMT methylation...
In this study, we investigated changes in resting state networks (RSNs) patients with gliomas located the left hemisphere and its relation to cognitive function. We hypothesized that long distance connection, especially between hemispheres, would be affected by presence of tumor. further these correlate with, or reflect observed gliomas. Resting functional MRI datasets from 12 healthy controls were used analysis. The tumor's effect on three well-known RSNs including default mode network...
Abstract Background High‐grade gliomas are highly lethal neoplasms representing approximately 20% of all intracranial tumors. Cationic liposome‐mediated interferon‐beta ( IFN‐ β) gene transfer has been found to induce regression experimental glioma. We have previously performed a pilot clinical trial evaluate the safety and effectiveness this β therapy in five patients with high‐grade Two showed more than 50% reduction while others had stable disease 10 weeks after treatment initiation....
Alexia and agraphia are disorders common to the left inferior parietal lobule, including angular supramarginal gyri. However, it is still unclear how these cortical regions interact with other sites what most important white matter tracts in relation reading writing processes. Here, authors present case of a patient who underwent an awake craniotomy for lobule glioma using direct subcortical electrostimulation. The use stimulation allowed identification specific associated writing. These...
Stricture is a major complication of wide endoscopic mucosal resection (ESD) the esophagus and its management requires multiple balloon dilation sessions [1]. Endoscopic intralesional injection triamcinolone being used as prophylactic treatment in patients whom areas mucosa were removed with ESD [2] [3].
OBJECTIVE Maximum extent of resection (EOR) for lower-grade and high-grade gliomas can increase survival rates patients. However, these infiltrative are often observed near or within eloquent regions the brain. Awake surgery is known benefit treatment associated with in that brain function be preserved. On other hand, intraoperative MRI (iMRI) has been successfully used to maximize tumors, which detect small amounts residual tumors. Therefore, authors assessed value combining awake...
The neurotrophins and the tyrosine kinase (Trk) B receptor may play a protective role in pathophysiology of cerebral ischemia. In this study, authors investigated whether reducing endogenous expression TrkB-binding modifies susceptibility to ischemic injury after 1-hour middle artery occlusion followed by 23 hours reperfusion filament model. Mice lacking both alleles for neurotrophin-4 ( nt4 −/− ) or deficient single allele brain-derived neurotrophic factor bdnf+/−) exhibited larger infarcts...
Central diabetes insipidus (CDI) is caused by deficiency of arginine vasopressin, an antidiuretic hormone. Patients with CDI manifest polyuria which usually compensated for increases in water intake. However, some patients are not able to sense thirst due the destruction osmoreceptors hypothalamus. These adipsic easily dehydrated and consequent dehydration could be life-threatening. The objective this study was investigate prognosis patients. We have reviewed 149 three hospitals using...
Deoxyribonucleic acid (DNA) methylation of tumor origin can be detected in the serum/plasma cancer patients. The aim this study was to detect aberrant p16 promoter as a potential diagnostic marker serum patients with diffuse glioma differentiate between gliomas and, particularly, those brainstem from others; done by using modified methylation-specific polymerase chain reaction technique.The used DNA extracted 20 astrocytic tumors and oligodendroglial corresponding samples. Serum samples 10...
The purpose of this study was to examine the 11C-methionine (MET) and 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) findings central nervous system (CNS) germinoma diagnostic utility these findings. We retrospectively evaluated cases 10 patients who were diagnosed with CNS according their histopathological or clinical All underwent pretreatment MET and/or FDG-PET scans, resultant images assessed qualitatively quantitatively. In qualitative assessments, we used 3- 5-grade...
Initial experiences are reviewed in an integrated operation theater equipped with intraoperative high-field (1.5 T) magnetic resonance (MR) imager and neuro-navigation (BrainSUITE®), to evaluate the indications limitations. One hundred consecutive cases were treated, consisting of 38 gliomas, 49 other tumors, 11 cerebrovascular diseases, 2 functional diseases. The feasibility usefulness evaluated for individual focusing on whether images (including diffusion tensor imaging) affected surgical...