A5077889129- Meningioma and schwannoma management
- Advanced Neuroimaging Techniques and Applications
- Neurofibromatosis and Schwannoma Cases
- Vascular Malformations Diagnosis and Treatment
- Neurobiology of Language and Bilingualism
- Intraoperative Neuromonitoring and Anesthetic Effects
- Glioma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Functional Brain Connectivity Studies
- Cerebrospinal fluid and hydrocephalus
- Hemispheric Asymmetry in Neuroscience
- Ophthalmology and Eye Disorders
- Intracranial Aneurysms: Treatment and Complications
- Pituitary Gland Disorders and Treatments
- Transcranial Magnetic Stimulation Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Adrenal and Paraganglionic Tumors
- Infectious Aortic and Vascular Conditions
- Growth Hormone and Insulin-like Growth Factors
- Anesthesia and Neurotoxicity Research
- RNA modifications and cancer
- Testicular diseases and treatments
- Medical History and Innovations
- IgG4-Related and Inflammatory Diseases
- Migraine and Headache Studies
Fukushima Medical University
2017-2024
Southern Tohoku General Hospital
2021
Social Insurance Saitama Chuo Hospital
2021
Dokkyo Medical University
2021
We conducted a feasibility study to investigate the therapeutic effect of bevacizumab on vestibular schwannomas (VS) associated with neurofibromatosis type 2 (NF2) in sample Japanese patients. Ten NF2 patients were selected between 2013 and 2018: nine women one man, ages ranging from 12 45 years (mean: 29.4). Bevacizumab was administered intravenously 5 mg/kg doses four times, an inter-dose interval weeks. Seventeen tumors followed for 3–72 months 39). A reduction baseline tumor volume at...
BACKGROUND Bifocal germ cell tumors, with primarily identical tissue composition, occur concurrently in the neurohypophyseal and pineal regions. OBSERVATIONS A 16-year-old male patient exhibited increased intracranial pressure symptoms, concurrent tumors regions, causing obstructive hydrocephalus. His serum human chorionic gonadotropin level was elevated, measuring 506.6 mIU/mL. Upon gross endoscopic examination, tumor appeared white, whereas red hemorrhagic. Because of limited sample size...
Neurofibromatosis type 2 (NF2) causes bilateral vestibular schwannomas (VSs), leading to deafness. VS is treated by surgery or radiation, but neither treatments prevent hearing loss. Bevacizumab was found be effective in suppressing the tumor’s growth and may help improve hearing. We are conducting a randomized, double-blind, multicenter clinical trial verify efficacy safety of bevacizumab NF2-related VS. The primary objective evaluate improving affected ear. One secondary objectives...
Objective Tissue injuries caused by the thermal effects of xenon light microscopes have previously been reported. Due to this, development a safe microscope source became necessity. A newly developed laser is evaluated regarding its effectiveness and safety as an alternative conventional source. Methods We tested new for surgical microscopes. Four experiments were conducted compare lights: 1) visual luminance comparison, 2) luminous chromaticity measurements, 3) examination analysis fatigue,...
OBJECTIVE Although sphenoidotomy is more commonly performed via the transnasal approach than transcranial approach, (TCS) remains indispensable for en bloc resection of locally advanced sinonasal malignant tumors (SNMTs) extending to skull base. TCS also enables transsphenoidal transposition temporoparietal galeal flap (TPGF) compensate lack vascularized reconstructive tissue after endoscopic base surgery. The objective this study was review authors’ surgical experience using with an...
Sinking skin flap syndrome or paradoxical brain herniation is an uncommon neurosurgical complication, which usually occurs in the chronic phase after decompressive craniectomy. We report a unique case presenting with these complications immediately craniectomy for severe traumatic injury.A 65-year-old man had right acute subdural hematoma (SDH), contusion of temporal lobe, and diffuse subarachnoid hemorrhage midline shift to left side. He underwent emergency evacuation SDH frontotemporal...
<b><i>Background:</i></b> Intraoperative indocyanine green videoangiography (ICG-VA) has been reported to be utilized in various cerebrovascular surgeries, wherein the blood flow is noticeably shown white with a black background. ICG alone, but not other structures, can observed using ICG-VA. We developed novel high-resolution intraoperative imaging system laser light source for simultaneously visualizing both visible and near-infrared (NIR) fluorescence images of...
Double or multiple pituitary adenomas expressing different types of transcription factors and collision tumors craniopharyngiomas are rare. In this report, we present a case adenoma two cell populations, Pit-1 SF-1, an craniopharyngioma tumor with coexisting Graves' disease. The patient had 16-mm stalk calcification optic chiasm compression but no visual dysfunction. Based on hormonal profile results, the in sella was considered nonfunctioning adenoma; nevertheless, invaded by lesion, which...
Abstract A few studies have identified the structural connection between premotor area and lateral prefrontal cortex (DLPFC) as frontal longitudinal system (FLS). This study investigated existence of a direct segment (none U-fibre) superior part FLS (sFLS), which connects dorsal (PMd) DLPFC analysed its asymmetry termination point patterns. dataset diffusion-weighted images from 48 subjects was used for generalised q-sampling imaging tractography. Additionally, white-fibre dissection...
Introduction Research on gender-based disparities in human brain structure has spanned over a century, yielding conflicting results and ongoing debate. While some studies indicate minimal distinctions, others consistently highlight differences the corpus callosum (CC), even after accounting for average size. Methods Diverging from previous approaches, this study examines morphology of entire CC fiber rather than solely focusing its midsagittal structure. Utilizing advanced neuroimaging...
Background Sialic acid, a critical component for cell membrane integrity, undergoes complex biosynthesis involving enzymes like sialyltransferases (STs), impacting cancer progression. Aberrant sialylation by STs is implicated in growth, invasion, and therapy resistance. Medulloblastoma (MB), pediatric brain tumor with distinct subgroups variable genetic alterations, poses uncertainty regarding the implications of sialylation. Methodology This study employs bioinformatic analyses on bulk...
White fiber dissection is essential for studying brain connections. However, preparation protocols have not been validated.
Introduction The degree to which each human brain hemisphere governs specific cognitive processes, such as language and handedness (the preference or dominance of one hand over the other), varies across individuals. Research has explored nature laterality in left-handed (LH) individuals, indicating that left-hemisphere for is commonly observed both left- right-handed populations. Advanced imaging techniques, including functional transcranial Doppler sonography fMRI, have revealed subtle...
Prosthetic valve endocarditis (PVE) can cause large cerebral vessel occlusion. Many reports suggested that mechanical thrombectomy (MT) is effective and useful for early diagnosis from the histopathological findings of thrombus. We present case a 62-year-old man, with history prosthetic aortic replacement pulmonary vein isolation his atrial fibrillation, who developed high fever an acute neurological deficit, left hemiplegia speech disorder. He was diagnosed as having right middle artery...
Abstract Introduction Meningioma is the most common adult primary brain tumor originating from meningeal coverings of and spinal cord. Commonly, World Health Organization (WHO) grade-I meningiomas are slowly growing surgically curative, some present with clinically aggressive behavior, invading skull base bone soft tissues by extending into extracranial spaces. Methods To detect genetic background Skull Base Invasive Low-grade (SBILM), we conducted a comprehensive analysis gene expression...
Objective: We evaluated the efficacy of intraoperative motor evoked potential monitoring (MEP) and a novel laser light imaging system to simultaneously visualize visual near-infrared fluorescence for indocyanine green angiography (dual-image VA [DIVA]) in aneurysm surgery.