A5102844710- Intracranial Aneurysms: Treatment and Complications
- Meningioma and schwannoma management
- Traumatic Brain Injury and Neurovascular Disturbances
- Intraoperative Neuromonitoring and Anesthetic Effects
- Vascular Malformations Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Cerebrospinal fluid and hydrocephalus
- Glioma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Neurosurgical Procedures and Complications
- Pituitary Gland Disorders and Treatments
- Neurofibromatosis and Schwannoma Cases
- Oral and Maxillofacial Pathology
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Aortic Disease and Treatment Approaches
- Bone Tumor Diagnosis and Treatments
- Genetic Associations and Epidemiology
- Fetal and Pediatric Neurological Disorders
- Esophageal and GI Pathology
- Peripheral Nerve Disorders
- Spinal Fractures and Fixation Techniques
- Moyamoya disease diagnosis and treatment
- Gout, Hyperuricemia, Uric Acid
- Adrenal and Paraganglionic Tumors
Tokyo Medical and Dental University
2024
Fukushima Medical University
2012-2021
Japan Science and Technology Agency
2017-2018
Tokushima Red Cross Hospital
2018
University of Tsukuba
2017
RIKEN Center for Advanced Intelligence Project
2017
Object. The lack of a specified intraoperative method for monitoring anterior choroidal artery (AChA) blood flow insufficiency (BFI) led the authors to devise checking BFI in this during aneurysm surgery. To end, relied on motor evoked potentials (MEPs) elicited by electrical stimulation hand cortex. Methods. study population consisted 108 patients with internal carotid (ICA) aneurysms who underwent surgery via standard frontotemporal craniotomy. After dura mater had been opened, grid...
Object. The usefulness of motor evoked potential (MEP) monitoring to detect blood flow insufficiency (BFI) in the cortical branches middle cerebral artery (MCA) and lenticulostriate arteries (LSAs) during MCA aneurysm surgery was investigated based on correlation between MEP somatosensory (SEP) monitoring. Methods. Fifty-three patients with aneurysms underwent accompanied by intraoperative SEP There no postoperative paresis 43 whom results remained unchanged. In other 10 patients, nine...
To obtain a clinically useful method of intraoperative monitoring visual evoked potentials (VEPs), the authors developed new light-stimulating device and introduced electroretinography (ERG) to ascertain retinal light stimulation after induction venous anesthesia.The stimulating consists 16 red light-emitting diodes embedded in soft silicone disc avoid deviation axis frontal scalp-flap reflection. After anesthesia with propofol, performed ERG VEP recording 100 patients (200 eyes) who were at...
The object of this study was to investigate patients with cerebral infarction in the area perforating arteries after aneurysm surgery.The authors studied incidence 1043 using computed tomography or magnetic resonance imaging and affected arteries, clinical symptoms, prognosis, operative maneuvers resulting blood flow disturbance.Among 46 (4.4%) infarction, were anterior choroidal artery (AChA) nine patients, lenticulostriate (LSA) hypothalamic two posterior thalamoperforating five vertebral...
✓ The authors report a case in which anterior choroidal artery (AChA) blood flow insufficiency due to aneurysm clip rotation was detected intraoperatively by motor evoked potential (MEP) monitoring and ischemia successfully avoided. patient had an incidentally discovered for occlusion of its neck performed through standard frontotemporal craniotomy without changing the MEP amplitude. After it confirmed that surrounding arteries were not stenotic, brain retractor on frontal lobe released;...
Object Dysphasia is one of the most serious complications skull base surgeries and results from damage to brainstem and/or cranial nerves involved in swallowing. Here, authors propose a method monitor function vagus nerve using endotracheal tube surface electrodes transcranial electrical stimulation during surgeries. Methods Fifteen patients with or tumors were enrolled. The used an record compound electromyographic responses vocalis muscle. Motor neurons stimulated corkscrew placed...
We report on a 24‐year‐old woman who was diagnosed as having Maffucci syndrome with anaplastic astrocytoma. analyzed the IDH 1 and 2 mutations of enchondroma, hemangioma astrocytoma tissues same somatic mosaic mutation in gene identified all these tissues. In addition, we additional TP 53 tissue but not other benign tumors. This is first detection an identical multiple patient syndrome. case unique supports 2‐dependent genetic pathway second‐hit model for gliomagenesis.
Background and Objective: Skull base chordomas are clinically malignant because of the difficulty total removal, high recurrence rate, occasional drop metastasis. Although aggressive surgical resection postoperative radiation have been recommended, long-term outcome remains unsatisfactory.Methods: From 1992 to 2011, we treated 24 patients with skull chordoma using removal as a principal strategy. approaches were selected according tumor extension remove surrounding bone completely possible....
Idiopathic normal pressure hydrocephalus (iNPH) is a dementia-inducing disorder. Primary cause of iNPH speculated to be reduction cerebrospinal fluid (CSF) absorption, which secondarily induces hydrocephalus, compression brain, and CSF production. Patients are treated by surgically inserting shunt deliver excess the abdominal cavity. The prognosis for cognitive improvement after surgery has been difficult predict. We therefore investigated various proteins, hoping find biomarker predictive...
To perform intraoperative fluorescence angiography (FAG) under a microscope without an integrated FAG function with reasonable cost and sufficient quality for evaluation, we made small easy to use device fluorescein (FAG filter). We investigated the practical of this filter during aneurysm surgery, revascularization brain tumor surgery. The consists two types filters: excitatory barrier filter. excludes all wavelengths except blue light passes long waves light. By adding function, from...
We performed an exome-wide association study (EWAS) to identify genetic variants - in particular, low‑frequency or rare with a moderate large effect size that confer susceptibility aortic aneurysm 8,782 Japanese subjects (456 patients aneurysm, 8,326 control individuals) and the use of Illumina HumanExome-12 DNA Analysis BeadChip Infinium Exome-24 arrays. The correlation allele frequencies for 41,432 single nucleotide polymorphisms (SNPs) passed quality was examined Fisher's exact test....
In this study, we performed exome-wide association studies (EWASs) to identify genetic variants that confer susceptibility ischemic stroke, intracerebral hemorrhage (ICH), or subarachnoid (SAH). EWAS for stroke was using 1,575 patients with condition and 9,210 controls, EWASs ICH SAH were 673 ICH, 265 9,158 controls. Analyses Illumina HumanExome-12 DNA Analysis BeadChip Infinium Exome-24 arrays. The relation of allele frequencies 41,339 41,332 single nucleotide polymorphisms (SNPs) passed...
We conducted a feasibility study to investigate the therapeutic effect of bevacizumab on vestibular schwannomas (VS) associated with neurofibromatosis type 2 (NF2) in sample Japanese patients. Ten NF2 patients were selected between 2013 and 2018: nine women one man, ages ranging from 12 45 years (mean: 29.4). Bevacizumab was administered intravenously 5 mg/kg doses four times, an inter-dose interval weeks. Seventeen tumors followed for 3–72 months 39). A reduction baseline tumor volume at...
An 8-year-old boy presented with a rare cerebral medulloepithelioma manifesting as headache, nausea, and vomiting. Neuroimaging demonstrated mass containing cyst in the left frontal lobe. Gross total resection of tumor 1-cm margin was performed under intraoperative monitoring. The histological diagnosis medulloepithelioma. Stereotactic radiotherapy (total dose 20 Gy) given to brain up 1 cm from surgical margin. Follow-up neuroimaging 5 years later showed no signs recurrence. He now attends...
To evaluate the usefulness of motor evoked potential (MEP) monitoring and mapping in arteriovenous malformation surgery.Intraoperative MEP was performed 21 patients whose AVMs were located near area or fed by arteries related to corticospinal tract detect blood flow insufficiency and/or direct injury map area.In 4 16 monitored for insufficiency, changed intraoperatively. In 2 patients, changes attributable temporary occlusion feeding artery (anterior choroidal lenticulostriate artery): 1...
Epidermoids tend to grow around and adhere critical neurovascular structures, but total or maximal tumor removal is recommended reduce the risk of recurrence. We describe our method combined microscopic endoscopic resection for extensive epidermoid tumors. Thirteen patients with tumors located in suprasellar, prepontine, surrounding cisterns underwent microsurgical a rigid endoscope high definition camera system. An anterior petrosal and/or pterional approach was selected 6 lateral...