A5030491895- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Neuroblastoma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Neutropenia and Cancer Infections
- CAR-T cell therapy research
- Sarcoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Blood disorders and treatments
- Cancer therapeutics and mechanisms
- Lung Cancer Treatments and Mutations
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Polyomavirus and related diseases
- Chronic Lymphocytic Leukemia Research
- Renal and related cancers
- Tumors and Oncological Cases
- Renal Transplantation Outcomes and Treatments
- Blood groups and transfusion
- Cancer, Hypoxia, and Metabolism
Fukushima Medical University Hospital
2014-2024
Tohoku University Hospital
2023
Kobe University Hospital
2016-2023
Saitama Medical University
2023
Imperial Household Agency
1993-2023
Tokai University
2020-2023
Japanese Society for Dialysis Therapy
2023
Fukushima Medical University
2013-2022
Pediatric Oncology Group
2022
Kyoto University
2020-2021
Recent studies revealed that a substantial proportion of patients with high-risk B-cell precursor acute lymphoblastic leukemia (BCP-ALL) harbor fusions involving tyrosine kinase and cytokine receptors, such as ABL1, PDGFRB, JAK2 CRLF2, which are targeted by inhibitors (TKIs). In the present study, transcriptome analysis or multiplex reverse transcriptase-PCR 373 BCP-ALL without recurrent genetic abnormalities identified 29 fusions. Clinically, male predominance (male/female: 22/7), older age...
Abstract Background Genome‐wide analysis studies have demonstrated that IKZF1 , CRLF2 and JAK2 gene alterations correlate with poor prognosis in pediatric B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL). However, the prognostic significance for these has not been clarified Japanese patients. Procedure A total of 194 patients BCP‐ALL enrolled Children's Cancer & Leukemia Study Group ALL 2004 clinical trial were assessed presence three different alterations: deletions, expression...
Purpose: To evaluate the safety and efficacy of multimodality treatment with vincristine, actinomycin-D, cyclophosphamide (VAC) therapy, surgery, radiotherapy according to U.S. Intergroup Rhabdomyosarcoma Study IV (IRS-IV), establish a central review system standard for intermediate-risk pediatric rhabdomyosarcoma in Japan. Patients methods: The JRS-I was single-arm, phase II trial open enrollment from June 2004 March 2009. received 12 cycles VAC every 3 weeks 42 weeks, local therapy...
Epstein‐Barr virus (EBV)‐related lymphoproliferative disorder (LPD) is a serious complication of haematopoietic stem cell transplantation (HSCT). To clarify the frequency, natural course and risk factors for LPD, we prospectively monitored 38 allogeneic (allo)‐HSCT patients, focusing on use anti‐thymocyte globulin (ATG). We used recently developed real‐time polymerase chain reaction assay to monitor EBV genome load. The subjects consisted 19 patients given ATG conditioning not ATG. Of ATG,...
Aplastic anaemia (AA) is defined as a pancytopenia caused by bone marrow failure, and its pathogenesis thought to involve autoimmune processes. Several predictive markers of the response immunosuppressive therapy (IST) have been proposed, which appear reflect immune pathophysiology. We prospectively investigated presence human leucocyte antigen (HLA)-DR15, minor population paroxysmal nocturnal haemoglobinuria (PNH)-type cells, antibodies recently identified autoantigen postmeiotic...
Steroid-induced osteonecrosis (ON) is a challenging complication encountered during modern chemotherapy for childhood acute lymphoblastic leukemia (ALL). We retrospectively assessed the incidence of ON and its risk factors in total 1095 patients enrolled 3 consecutive Japanese Children's Cancer Leukemia Study Group ALL studies (ALL941 [1994 to 2000], n=464; ALL2000 [2000 2004], n=305; ALL2004 [2004 2010], n=326). was diagnosed 16 patients, whom 15 were symptomatic. The cumulative 0.76%...
Long-term survival rates for pediatric patients with cancer have significantly improved, but novel approaches are desired those refractory/relapsed solid tumors. Recently, programed cell death-1/programed death-ligand-1 blockade has emerged as an effective option many intractable cancers. However, not all show objective response to such therapy. On the other hand, several checkpoint pathways, including Herpes virus entry mediator (HVEM)/B- and T-lymphocyte attenuator (BTLA), galectin-9...
The majority of minimal residual disease (MRD)-positive patients with acute lymphoblastic leukemia (ALL) have poor outcomes. ALL2000 study was performed to evaluate the efficacy augmented chemotherapy based on MRD-restratification in childhood ALL.Between 2000 and 2004, 305 eligible precursor B or T-cell ALL were enrolled study. ALL941-based therapy protocol utilized PCR MRD assays using Immunoglobulin receptor gene rearrangements. They initially stratified into three risk-groups according...
Background Although the therapeutic outcome of acquired aplastic anemia has improved markedly with introduction immunosuppressive therapy using antithymocyte globulin and cyclosporine, a significant proportion patients subsequently relapse require second-line therapy. However, detailed analyses relapses in children are limited.Design Methods We previously conducted two prospective multicenter trials for anemia: AA-92 AA-97, which began 1992 1997, respectively. In this study, we assessed...
Abstract This study reviewed the clinical characteristics of 112 pediatric B‐cell precursor acute lymphoblastic leukemia ( BCP ‐ ALL ) patients with TCF 3‐ PBX 1 fusion treated according to Japan Association Childhood Leukemia Study JACLS 02 protocol n = 82) and Children's Cancer Group CCLSG 2004 30). The 3‐year event‐free survival EFS overall OS rates were 85.4 ± 3.9% 89.0 3.5% in cohort, 5‐year 82.8 7.0% 86.3 6.4% respectively, which are comparable those reported western countries....
ACD-A solution containing sodium citrate and citric acid is used as an anticoagulant agent during peripheral blood progenitor cell (PBPC) harvesting, in rare cases can cause fatal intoxication. The aim of this study was to establish effective methods for stabilizing ionized calcium (ICa) levels PBPC harvesting.ICa measured 46 apheresis procedures conducted 26 patients. Four patients four were infused with gluconate before harvesting; three six when symptoms intoxication appeared; five...
Abstract Background Despite the progress of therapy, about 25% patients with hepatoblastoma succumb to disease. Prognostic factors, as well improved therapies, are needed for these patients. We investigated incidence and clinical significance genetic epigenetic aberrations in hepatoblastoma. Procedure β ‐ catenin mutation was analyzed by sequencing promoter hypermethylation RASSF1A SFRP genes methylation‐specific PCR after bisulfate treatment DNA samples from 39 hepatoblastomas. Association...
Clinical and pharmacokinetic studies were performed regarding the toxicity of methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-α-D-glucopyranoside (MCNU) with other drugs, in conjunction a peripheral blood stem cell autograft (PBSCT), for treating 26 children acute leukemia or lymphoma associated high-risk features. In early phase study, MCNU (300 to 500 mg/m2) was administered cytosine arabinoside (Ara-C) (1.6 16 g/m2),etoposide (VP-16) (0.8 1.6 g/m2), cyclophosphamide (CY) (100 200...