A5089394265- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Cytomegalovirus and herpesvirus research
- Neuroblastoma Research and Treatments
- Renal Transplantation Outcomes and Treatments
- Immunotherapy and Immune Responses
- Viral-associated cancers and disorders
- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immunodeficiency and Autoimmune Disorders
- Autoimmune and Inflammatory Disorders Research
- Polyomavirus and related diseases
- Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Pancreatic function and diabetes
- Pneumothorax, Barotrauma, Emphysema
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Ubiquitin and proteasome pathways
- Pleural and Pulmonary Diseases
Fukushima Medical University Hospital
2017-2024
Pediatric Oncology Group
2022
Fukushima Medical University
2016-2021
Long-term survival rates for pediatric patients with cancer have significantly improved, but novel approaches are desired those refractory/relapsed solid tumors. Recently, programed cell death-1/programed death-ligand-1 blockade has emerged as an effective option many intractable cancers. However, not all show objective response to such therapy. On the other hand, several checkpoint pathways, including Herpes virus entry mediator (HVEM)/B- and T-lymphocyte attenuator (BTLA), galectin-9...
Abstract Background Epstein–Barr virus‐related post‐transplantation lymphoproliferative disease ( EBV ‐ PTLD ) is a serious complication in hematopoietic stem cell transplantation HSCT recipients. Methods We conducted retrospective study to investigate the incidence and potential risk factors for reactivation assess efficacy of management with pre‐emptive rituximab children who had T‐cell‐replete haploidentical TCR ‐haplo‐ SCT low‐dose anti‐thymocyte globulin ATG ). DNA level peripheral...
GF is one of the fatal complications allogeneic HSCT. To rescue patients with primary GF, a second HSCT should be conducted as soon possible, but optimal donor source and technique have yet to established. In this study, we retrospectively analyzed six children hematologic malignancies who received TCR-haploidentical for GF. The median interval between prior was 37.5 days. All fludarabine ATG containing reduced-intensity re-conditioning before patients, except died early, achieved both...
Pneumorrhachis refers to the clinical presentation of air within spinal canal, and it is rarely associated with pneumomediastinum, particularly in young children. pneumomediastinum generally asymptomatic. Here we report 2 unusual cases involving very children pneumorrhachis secondary present a review relevant literature. Case 1 involved 4-year-old girl who presented wheezing, violent coughing, dyspnea bronchiolitis. 3-year-old boy interstitial pneumonia possibly caused by graft-versus-host...
Ganglioneuroblastoma, nodular is defined as a composite tumor of biologically distinct clones. The peripheral neuroblastic tumors in this category are characterized by the presence grossly visible neuroblastoma nodules coexisting with ganglioneuroblastoma, intermixed, or ganglioneuroma. Making correct diagnosis often difficult biopsy partial resection, because nodule could be hidden and not sampled for pathological examination. We report case Japanese boy aged 3 years, 8 months, an...
Abstract Background: Haploidentical hematopoietic stem cell transplantation (HSCT) is a useful therapy for relapsed/refractory acute leukemia or lymphoma because of the strong graft‐vs‐leukemia (GVL) effect. However, it often accompanied by severe graft‐versus‐host disease (aGVHD), which most serious complication after haploidentical HSCT. Thus, important to control severity aGVHD while maintaining GVL In our experience pediatric HSCT, takes several days become appearance initial symptoms,...
Chronic myeloid leukemia (CML) is an uncommon entity in pediatric patients. CML chronic phase (CML-CP) has a relatively favorable outcome. Leukostasis occurs 9.7% of patients with CML. One the most serious leukostasis-related complications intracranial hemorrhage (ICH). However, this very rare CML-CP, and few early mortalities have been reported leukostasis. We report case 14-year-old female patient CML-CP who developed ICH 8 days after admission. A girl symptoms fatigue slight fever was...
Despite intensive multimodal therapies, the prognosis of relapsed/ refractory Ewing sarcoma family tumors (RR-ESFTs) is dismal. Some case reports using allogeneic stem cell transplantation (allo SCT) for RR-ESFTs have been reported, however, efficacy allo SCT yet to be established.The purpose this study was evaluate response and toxicity T-cell replete haploidentical (TCR-haplo-SCT) in RR-ESFTs.In study, we retrospectively analyzed six patients with who received TCR-haplo-SCT. Four had...
Background: The prognosis of refractory/relapsed B-cell precursor acute lymphoblastic leukemia (BCP-ALL) remains dismal owing to acquired resistance chemotherapeutic agents. This study aimed evaluate the efficacy T-cell replete HLA haploidentical hematopoietic stem cell transplantation (TCR-haplo-HSCT) for pediatric BCP-ALL (RR-BCP-ALL). Methods: Nineteen patients with RR-BCP-ALL underwent TCR-haplo-HSCT between 2010 and 2019 at Fukushima Medical University Hospital. disease status included...
TCF3-HLF-positive B-cell precursor acute lymphoblastic leukemia (BCP-ALL) has an extremely poor prognosis. A 2-year-old boy with BCP-ALL had isolated extramedullary relapse in multiple bones after allogeneic hematopoietic stem cells transplantation (HSCT) from a human leukocyte antigen-matched unrelated donor. In this study, he received T-cell-replete haploidentical HSCT (TCR-haplo-HSCT) his father when nonremission state, which resulted sustained complete remission for over 3 years. Immune...
Cancer vaccines that induce endogenous antitumor immunity represent an ideal strategy to overcome intractable cancers. However, doing this against a pre-established cancer using autologous immune cells has proven be challenging. "Allogeneic effects" refers the induction of response upon adoptive transfer allogeneic lymphocytes without utilizing hematopoietic stem cell transplantation. While have potent ability activate host as adjuvant, novel strategies can activity in patients remain unmet...
HLA半合致造血細胞移植（haploidentical hematopoietic stem cell transplantation: Haplo-HSCT）は再発や治療抵抗性，予後不良因子を認める造血器腫瘍症例を対象に，強力な抗腫瘍効果を期待し実施されている。Haplo-HSCT後再発した症例の一部では白血病細胞の不適合HLA喪失が報告されている。Haplo-HSCT後再発した6症例について，白血病細胞を含む末梢血，骨髄血由来DNAを用いてHLA DNA typingを実施し，患者特異的HLAハプロタイプの有無から不適合HLA喪失の可能性について評価した。6症例中2症例で不適合HLAが検出できない水準までの喪失（低下）を認めた。Haplo-HSCT後の再発症例では以後の治療方針決定のため，不適合HLA喪失の有無の評価が重要である。
10544 Background: Despite the significant improvements of long-term survival rates for pediatric cancers, prognosis refractory/relapsed solid tumors are extremely poor, and novel strategies desired. Recently, tumor immunotherapies such as anti-PD-1/PD-L1 antibodies have been recognized an effective option many intractable cancers. However, there still a substantial number patients who do not show objective responses to PD-1/ PL-L1 blockades. On other hand, like PD-1/PD-L1, immune checkpoint...