A5101889062- T-cell and Retrovirus Studies
- Vector-Borne Animal Diseases
- Animal Disease Management and Epidemiology
- Platelet Disorders and Treatments
- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- Hemoglobin structure and function
- Chronic Myeloid Leukemia Treatments
- Multiple Myeloma Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Mycobacterium research and diagnosis
- Viral-associated cancers and disorders
- Autoimmune and Inflammatory Disorders
- Kruppel-like factors research
- Blood Coagulation and Thrombosis Mechanisms
- Body Composition Measurement Techniques
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Liver physiology and pathology
- Blood disorders and treatments
- Immune Cell Function and Interaction
- Clinical Nutrition and Gastroenterology
- Fungal Infections and Studies
- Blood transfusion and management
- Peripheral Neuropathies and Disorders
- Quality and Safety in Healthcare
Kagoshima University Hospital
2011-2024
Sendai Shakai Hoken Hospital
2024
Kagoshima University
2019-2023
Imamura Hospital
2006-2019
Adult T cell leukemia/lymphoma (ATL) is an aggressive peripheral neoplasm with very poor prognosis. Allogeneic hematopoietic stem transplantation (allo-HSCT) has been reported as a curative treatment modality for ATL. However, there are no reports comparing chemotherapy alone allo-HSCT in In this report, we retrospectively analyzed data patients treated (n = 29, median age 55 years) or without 37, 58 ATL Kagoshima University Hospital, located one of the most endemic areas human lymphotropic...
Mogamulizumab (Mog), an anti-C-C motif chemokine receptor 4 (CCR4) antibody, is a therapeutic for adult T-cell leukemia/lymphoma (ATL). Injuries of normal regulatory T cells (Tregs) which express CCR4 by Mog could result in immune-related adverse events including graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). In this study, we retrospectively analyzed 25 patients among 39 with ATL who received allo-HSCT. We found that the risk grade II...
Adult T-cell leukemia/lymphoma (ATL) is a peripheral malignancy caused by human leukemia virus type-I (HTLV-1). This study investigated whether the number of newly diagnosed patients with ATL decreasing in background declining individuals infected HTLV-1 Kagoshima, Japan, one most endemic areas world. We retrospectively analyzed between January 2001 and December 2021 three major hospitals. The B-cell non-Hodgkin lymphoma (B-NHL) same period was examined as an internal control. One thousand...
7504 Background: No standard of care for elderly patients with aggressive adult T-cell leukemia/lymphoma (ATL) has been established yet. We assessed the efficacy an anti-CCR4 antibody, mogamulizumab (Moga) combined biweekly cyclophosphamide (CPA), doxorubicin (DXR), vincristine (VCR), and prednisone (PSL) (Moga-CHOP-14) untreated ATL. Methods: In this phase 2 trial conducted at 21 centers in Japan, CCR4-positive ATL aged 66 years or older 56-65 who were not candidates allogeneic...
Abstract Objectives Adult T‐cell leukemia/lymphoma (ATL) is an intractable malignancy caused by long‐term infection with human leukemia virus type‐1 (HTLV‐1). While ATL pathogenesis has been associated HTLV‐1‐derived oncogenic proteins, including Tax and HBZ, the contribution of genomic aberrations remains poorly defined. Methods To elucidate basis ATL, whole exome sequencing was performed on cells from 47 patients aggressive ATL. Results We discovered novel mutation RLTPR Q575E in four...
A 24-year-old man was found to have an ileocecal ulcer by colonoscopy. pathological diagnosis of diffuse large B-cell lymphoma (DLBCL) with positive reaction Epstein-Barr encoding region (EBER) in situ hybridization made based on analysis the specimen. Acquired immunodeficiency syndrome (AIDS) complicated pneumocystis jirovecii pneumonia also diagnosed. As no other significant lymphomatous lesions were identified further examination, a clinical EBV-positive mucocutaneous (EBVMCU) made....
Essential thrombocythemia (ET) cases without canonical JAK2, CALR, or MPL mutations, that is, triple-negative (TN) ET, have been found in 10%-20% of ET cases. Owing to the limited number TN cases, its clinical significance remains unclear. This study evaluated ET's characteristics and identified novel driver mutations. Among 119 patients with 20 (16.8%) had no JAK2/CALR/MPL Patients tended be younger lower white blood cell counts lactate dehydrogenase values. We putative mutations 7 (35%):...
A tyrosine kinase inhibitor (TKI) was used to treat the patient, a 35-year-old woman who diagnosed with chronic myeloid leukemia at age of 22 years. Since four-year deep molecular response (DMR) obtained, spontaneous pregnancy planned under TKI withdrawal. Even though her disease had advanced MR2.0 time confirmation, 2 months from cessation, interferon α therapy initiated in light patient's history. Later, patient reached MR3.0, gave birth healthy baby, and maintained MR3.0-4.0. resumed...
Background: No standard of care for elderly patients with aggressive adult T-cell leukemia/lymphoma (ATL) has been established yet. We assessed the efficacy an anti-CCR4 antibody, mogamulizumab (Moga)combined biweekly cyclophosphamide (CPA), doxorubicin (DXR), vincristine (VCR), and prednisone (PSL) (Moga-CHOP-14) untreated ATL. Methods: In this phase 2 trial conducted at 21 centers in Japan, CCR4-positive ATL aged 66 years or older 56–65 who were not candidates allogeneic hematopoietic stem...
POEMS syndrome is often complicated by pulmonary hypertension. The standard therapy for patients with high-dose chemotherapy followed autologous stem cell transplantation. However, the safety of hypertension remains unclear, and optimal these yet to be establishment. Herein, we report case a 54-year-old woman accompanied We successfully safely performed lenalidomide dexamethasone (Ld) transplantation, which improved her Thus, Ld can considered as safe effective syndrome.
Adult T-cell leukemia-lymphoma (ATL) is a peripheral malignancy caused by the human lymphotropic virus, type I and it has an extremely poor prognosis. A 66-year-old man with severe hepatic damage, massive pleural effusion ATL cell infiltration-induced ascites was referred to our department. Reduced-intensity cytotoxic chemotherapy attempted, but could not continue due persistent hyperbilirubinemia. Laboratory results also showed elevated lactate dehydrogenase (LDH) serum albumin levels were...