A5021620288- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Medical Imaging Techniques and Applications
- T-cell and Retrovirus Studies
- Radiation Detection and Scintillator Technologies
- Lymphoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Chronic Myeloid Leukemia Treatments
- Platelet Disorders and Treatments
- Vector-Borne Animal Diseases
- Spine and Intervertebral Disc Pathology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Nuclear Physics and Applications
- Acute Myeloid Leukemia Research
- Peptidase Inhibition and Analysis
- Cancer Treatment and Pharmacology
- Advanced MRI Techniques and Applications
- Ubiquitin and proteasome pathways
- Dental Implant Techniques and Outcomes
- Neutropenia and Cancer Infections
- Musculoskeletal pain and rehabilitation
- Immune Cell Function and Interaction
- Automotive and Human Injury Biomechanics
- Atomic and Subatomic Physics Research
- Oral microbiology and periodontitis research
Iwate Medical University
2016-2025
Mirai Hospital
2022-2024
Kumamoto University
2014-2024
National Institutes for Quantum Science and Technology
2023
Japanese Red Cross Nagoya Daiichi Hospital
2018-2019
Furukawa Electric (Japan)
2012-2017
Heart Life Hospital
2016
Kumamoto University Hospital
2016
Sasebo City General Hospital
2016
Ehime University Hospital
2016
Purpose Few treatment options exist for adult T-cell leukemia/lymphoma (ATL), and the prognosis this disease is poor. A phase I study of lenalidomide demonstrated preliminary antitumor activity in patients with relapsed ATL. The current II evaluated efficacy safety monotherapy or recurrent Patients Methods 20 years age older acute, lymphoma, unfavorable chronic subtype ATL, who had received one more prior anti-ATL systemic chemotherapy achieved stable better on their last therapy subsequent...
Due to the accident of Fukushima Daiichi Nuclear Power Plant, some areas were contaminated by released radioisotopes (mainly 137Cs and 134Cs). Effective decontamination is demanded encourage evacuated people return. This paper proposes a new survey system using an unmanned helicopter equipped with Compton camera for localizing radionuclides. As prototype, 32 Ce:Gd3(Al,Ga)5O12 (GAGG) crystals coupled 16 silicon photomultipliers avalanched photodiodes as scatterer absorber, respectively. A...
Adult T-cell leukemia/lymphoma (ATL) is a mature neoplasm and classified into four subtypes (acute, lymphoma, chronic, smoldering) according to the Shimoyama classification, established in 1991 through several nationwide surveys based on clinical diversity of patients diagnosed 1983-1987 Japan. Thereafter, no such studies have been conducted. Recently, we conducted hospital survey using method 1980s studies, collected baseline data 996 ATL 2010-2011 from 126 hospitals, reported their unique...
Abstract It remains elusive how driver mutations, including those detected in circulating tumor DNA (ctDNA), affect prognosis relapsed/refractory multiple myeloma (RRMM). Here, we performed targeted-capture sequencing using bone marrow plasma cells (BMPCs) and ctDNA of 261 RRMM cases uniformly treated with ixazomib, lenalidomide, dexamethasone a multicenter, prospective, observational study. We 24 47 recurrently mutated genes BMPC ctDNA, respectively. In addition to clonal...
Abstract: The chemokine stromal cell‐derived factor‐1 (SDF‐1/CXCL12) and its receptor, CXCR4, are involved in a number of facets the regulation hematopoiesis at level hematopoietic stem (HSCs) progenitor (HPCs) cells. Modulation this ligand–receptor interaction may be clinical utility. We now report that: (1) CC chemokine, macrophage inflammatory protein‐1α (MIP‐1α/CCL3) synergizes with AMD3100 (an antagonist binding SDF‐1/CXCL12 to CXCR4) rapidly mobilize HPCs blood mice; moreover,...
The prognostic value of models such as the international index (IPI) in patients with malignant lymphomas treated a combination rituximab, doxorubicin, cyclophosphamide, vincristine, and prednisolone is well established. However, whether these apply to tetrahydropyranyl adriamycin, (R-THP-COP) unclear. This retrospective analysis included 101 Diffuse large B-cell lymphoma (DLBCL) R-THP-COP. primary endpoint was overall survival (OS). secondary endpoints were progression-free (PFS), complete...
BACKGROUND When skeletal metastasis is the presenting problem and primary site occult, there a need to identify as soon possible. However, search for tumor often time-consuming difficult. The purpose of this study was analyze efficacy particular diagnostic approaches devise an efficient optimal strategy. METHODS Among 213 patients with treated between 1990 1996 were 64 in whom lesions first manifestation malignancy. authors retrospectively analyzed both final diagnosis process by which it...
A kinematic analysis of cervical intervertebral disc deformation during simulated whiplash using the whole spine with muscle force replication model was performed.To quantify anulus fibrosus fiber strain, shear and axial in whiplash.Clinical studies have documented acute injury accelerated degeneration patients, although there has been no biomechanical investigation mechanisms.A bench-top sled used to simulate at 3.5, 5, 6.5, 8 g six specimens. The 30 degrees 150 strains, deformations were...
A newly developed biofidelic whole cervical spine (WCS) model with muscle force replication (MFR) was subjected to whiplash simulations of varying intensity, and the resulting injuries were evaluated through changes in intervertebral flexibility.To identify soft tissue injury threshold based on peak T1 horizontal acceleration association between magnitude severity from simulated using WCS + MFR model.Whiplash has been mathematical models, cadavers, volunteers, WCSs. The measurement...
Most patients with multiple myeloma (MM) are considered to be incurable, and relapse owing minimal residual disease (MRD) is the main cause of death among these patients. Therefore, new technologies assess deeper response required.We retrospectively analyzed 125 MM who underwent high-dose melphalan plus autologous stem-cell transplantation (ASCT) detect MRD in autograft/bone marrow (BM) cells using a next-generation sequencing (NGS)-based method allele-specific oligonucleotide-polymerase...
An improved light-weight Compton camera exhibiting low power consumption was developed to be mountable on an unmanned helicopter detect cesium radiation hot spots and confirm the decontamination effect of cesium-affected areas. increase in Ce:Gd3(Al,Ga)5O12 scintillator array from 4 × 8 expansion interlayer distance enhanced detection efficiency angular resolution, respectively. Measurements were performed over Ukedo riverbed Namie, Fukushima Prefecture (Japan). The helicopter's flight path...
The signaling lymphocytic activation molecule family (SLAMF7; also known as CS1 or CD319) is highly expressed on plasma cells from multiple myeloma (MM) well natural killer (NK) and a well-known therapeutic target of elotuzumab. objective this study was to evaluate the clinical significance serum soluble SLAMF7 (sSLAMF7) levels in patients with MM (n=103) furthermore impact sSLMF7 antitumor activity anti-SLAMF7 antibody. Thirty-one percent patients, but not monoclonal gammopathy undetermined...
Summary Megakaryocytes (MKs) generate platelets via intravascular protrusions termed proplatelets, which are tandem arrays of platelet-sized swellings with a beaded appearance. However, it remains unclear whether all in fact become and MKs without forming proplatelets. Here, we visualised the sequential phases MK fragments living mouse bone marrow (BM), using intravital microscopy, examined their ultrastructure. The formation was observed to be highly dynamic process, size shape changed...
Adult T-cell leukemia-lymphoma (ATL) is a malignancy that endemic to Japan. In this latest nationwide study of ATL, we collected the data from 4 registries patients diagnosed in 2012-2013; Hematology Blood Disease, Skin Cancer Society, Hospital-Based Registries, and information hospitals participated Japanese survey ATL 2010-2011. present study, 2614 with were based on registries, 117 departments registered 1042 patients. Among these patients, 984 eligible for analysis. The median age at...
The surface property of commercially pure titanium (cpTi) was improved by forming a thin hydroxyapatite (HA) layer anodic oxidation and hydrothermal treatment (HA/cpTi). We hypothesize that the adhesion macrophages to HA/cpTi surfaces is important process osseointegration. This study investigates effect on expression bone morphogenetic protein-2 (BMP-2). murine macrophage cell line J774A.1 cultured polished cpTi (S/cpTi). Macrophage examined SEM, 0-72 h following plating onto S/cpTi. BMP-2...
In Brief Study Design. A biomechanical study of intervertebral foraminal narrowing during simulated automotive rear impacts. Objectives. To quantify width, height, and area impact, evaluate the potential for nerve root ganglion impingement in individuals with without spondylosis. Summary Background Data. Muscle weakness paresthesias, documented whiplash patients, have been associated neural compression within cervical foramen. our knowledge, no studies comprehensively examined dynamic...