A5088707445- Multiple Myeloma Research and Treatments
- Bone health and treatments
- Peptidase Inhibition and Analysis
- Bone Metabolism and Diseases
- Cancer Mechanisms and Therapy
- Protein Degradation and Inhibitors
- Monoclonal and Polyclonal Antibodies Research
- Cancer Treatment and Pharmacology
- Glycosylation and Glycoproteins Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Immunotherapy and Immune Responses
- Labor market dynamics and wage inequality
- Cancer therapeutics and mechanisms
- TGF-β signaling in diseases
- Cytokine Signaling Pathways and Interactions
- Histone Deacetylase Inhibitors Research
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- NF-κB Signaling Pathways
- Acute Myeloid Leukemia Research
- Gender, Labor, and Family Dynamics
- Protease and Inhibitor Mechanisms
- Drug Transport and Resistance Mechanisms
- Parathyroid Disorders and Treatments
- Immune Cell Function and Interaction
Tokushima University
2015-2024
National Hospital Organization
2013-2024
Ehime Medical Center
2002-2024
Konan University
2010-2024
National Center of Neurology and Psychiatry
2023
Osaka University
2020-2023
Tokushima University Hospital
2004-2022
Zenyaku Kogyo (Japan)
2022
Keio University
2017-2021
Institute of Biomedical Science
2015-2021
Superparamagnetic nanoparticles (SPIONs) could enable cancer theranostics if magnetic resonance imaging (MRI) and hyperthermia treatment (MHT) were combined. However, the particle size of SPIONs is smaller than pores fenestrated capillaries in normal tissues because superparamagnetism expressed only at a <10 nm. Therefore, leak from tissues, resulting low accumulation tumors. Furthermore, MHT studies have been conducted an impractical way: direct injection materials into tumor application...
We report the synthesis of smart nanoparticles (NPs) that generate heat in response to an alternating current magnetic field (ACMF) and sequentially release anticancer drug (doxorubicin, DOX). further study vivo therapeutic efficacy combination hyperthermia (MHT) chemotherapy using NPs for treatment multiple myeloma. The are composed a polymer with glass-transition temperature (T g) 44°C, which contains clustered Fe3O4 DOX. produce when ACMF is applied rise above softens phase leads MHT...
Abstract Purpose: Similar to osteoclastogenesis, angiogenesis is enhanced in the bone marrow myeloma parallel with tumor progression. We showed previously that cells and osteoclasts are mutually stimulated form a vicious cycle lead enhance both osteoclastogenesis growth. The present study was undertaken clarify whether cell-osteoclast interaction enhances there any mutual stimulation between angiogenesis. Experimental Design: Myeloma monocyte-derived were cocultured, angiogenic activity...
Multiple myeloma (MM) expands almost exclusively in the bone marrow and generates devastating lesions, which formation is impaired osteoclastic resorption enhanced. TGF-beta, a potent inhibitor of terminal osteoblast (OB) differentiation, abundantly deposited matrix, released activated by enhanced MM. The present study was therefore undertaken to clarify role TGF-beta its inhibition tumor growth MM.TGF-beta suppressed OB differentiation from stromal cells MC3T3-E1 preosteoblastic cells, also...
Fibroblast growth factor (FGF) 23 produced by bone is a hormone that decreases serum phosphate (Pi). Reflecting its central role in Pi control, FGF23 tightly regulated alterations. levels are the transcriptional event and posttranslational cleavage into inactive fragments before secretion. For latter, O-glycosylation of GALNT3 gene product prevents cleavage, leading to an increase FGF23. However, molecular basis sensing regulation remains elusive. In this study, we showed high diet enhanced...
Physical therapies including photodynamic therapy (PDT) and photothermal (PTT) can be effective against diseases that are resistant to chemotherapy remain as incurable malignancies (for example, multiple myeloma). In this study, enhance the treatment efficacy for myeloma using synergetic effect brought about by combining PDT PTT, iodinated silica/porphyrin hybrid nanoparticles (ISP HNPs) with high photostability developed. They generate both 1 O 2 heat irradiation from a light‐emitting diode...
Abstract Exercise results in mechanical loading of the bone and stimulates energy expenditure adipose tissue. It is therefore likely that secretes factors to communicate with tissue response loading. Interleukin (IL)−11 known be expressed bone, it upregulated by loading, enhances osteogenesis suppresses adipogenesis. Here, we show systemic IL-11 deletion (IL-11 −/− ) reduced mass, suppressed formation enhanced expression Wnt inhibitors, signaling. At same time, enhancement resorption...
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KL-6 in serum and bronchoalveolar lavage fluid has been reported to be a sensitive marker indicating the activity of fibrosing lung diseases. The molecule is clustered MUC1 mucin according findings immunohistochemical cytometric studies. To elucidate pathogenic role disease, we characterized its biochemical properties examined whether purified chemotactic for human fibroblasts vitro using modified Boyden chambers. Biochemical were similar those other mucins previously reported. promoted...
Journal Article Effect of Calponin on Actin-Activated Myosin ATPase Activity Get access Masahiro Abe, Abe 2 The Second Department Internal Medicine, Ehime University School MedicineOnsen-gun, 791-02 2To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Katsuhito Takahashi, Takahashi Kunio Hiwada Biochemistry, Volume 108, Issue 5, November 1990, Pages 835–838, https://doi.org/10.1093/oxfordjournals.jbchem.a123289 Published:...
Cancer cells eventually acquire drug resistance largely via the aberrant expression of ATP-binding cassette (ABC) transporters, ATP-dependent efflux pumps. Because cancer produce ATP mostly through glycolysis, in present study we explored effects inhibiting glycolysis on ABC transporter function and sensitivity malignant cells. Inhibition by 3-bromopyruvate (3BrPA) suppressed production cells, restored retention daunorubicin or mitoxantrone transporter-expressing, RPMI8226 (ABCG2), KG-1...
Transforming growth factor-beta (TGF-beta) is crucial in numerous cellular processes, such as proliferation, differentiation, migration, and apoptosis. TGF-beta signaling transduced by intracellular Smad proteins that are regulated the ubiquitin-proteasome system. ubiquitin regulatory factor 2 (Smurf2) prevents bone morphogenetic protein interacting with Smads inducing their ubiquitin-mediated degradation. Here we identified Pin1, a peptidylprolyl cis-trans isomerase, novel binding Smads....
Abstract It remains elusive how driver mutations, including those detected in circulating tumor DNA (ctDNA), affect prognosis relapsed/refractory multiple myeloma (RRMM). Here, we performed targeted-capture sequencing using bone marrow plasma cells (BMPCs) and ctDNA of 261 RRMM cases uniformly treated with ixazomib, lenalidomide, dexamethasone a multicenter, prospective, observational study. We 24 47 recurrently mutated genes BMPC ctDNA, respectively. In addition to clonal...
Denosumab, a fully human monoclonal antibody that inhibits the receptor activator of nuclear factor-κB ligand, activation osteoclasts. Some clinical trials have shown denosumab suppresses bone resorption in patients with advanced cancer, but hypocalcemia has been reported as serious adverse effect after administration denosumab. It is difficult to predict such cases because risk factors for denosumab-induced not reported. Accordingly, aim present study was identify induced by We...
ABSTRACT Activating mutations of calcium-sensing receptor (CaSR) cause autosomal dominant hypocalcemia (ADH). ADH patients develop hypocalcemia, hyperphosphatemia, and hypercalciuria, similar to the clinical features hypoparathyroidism. The current treatment is other forms hypoparathyroidism, using active vitamin D3 or parathyroid hormone (PTH). However, these treatments aggravate hypercalciuria renal calcification. Thus, new therapeutic strategies for are needed. Calcilytics allosteric...