A5055637993- Bone health and treatments
- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- Parathyroid Disorders and Treatments
- Bone and Dental Protein Studies
- Alkaline Phosphatase Research Studies
- Vitamin D Research Studies
- Bone Tissue Engineering Materials
- Bone and Joint Diseases
- Connective tissue disorders research
- Genetic Syndromes and Imprinting
- Heterotopic Ossification and Related Conditions
- Dermatological and Skeletal Disorders
- Fibroblast Growth Factor Research
- Vitamin K Research Studies
- Osteoarthritis Treatment and Mechanisms
- dental development and anomalies
- Bone fractures and treatments
- RNA modifications and cancer
- Protease and Inhibitor Mechanisms
- Biomarkers in Disease Mechanisms
- Inflammatory mediators and NSAID effects
- Cytokine Signaling Pathways and Interactions
- Dental materials and restorations
- Cervical and Thoracic Myelopathy
Hokkaido University
2016-2025
University of Dental Medicine
2022-2024
Hokkaido University of Science
2021
Nagoya University
2021
Niigata University
2014-2017
Nagasaki University
2016-2017
Hospital Estadual Mário Covas
2017
Universidade Federal de Sergipe
2016
Shandong University
2014-2015
The strength of bone depends on quantity and quality. Osteocalcin (Ocn) is the most abundant noncollagenous protein in produced by osteoblasts. It has been previously claimed that Ocn inhibits formation also functions as a hormone to regulate insulin secretion pancreas, testosterone synthesis testes, muscle mass. We generated Ocn-deficient (Ocn-/-) mice deleting Bglap Bglap2. Analysis Ocn-/-mice revealed not involved regulation quantity, glucose metabolism, synthesis, or orientation degree...
The mammalian skeleton stores calcium and phosphate ions in bone matrix. Osteocytes osteocyte lacunae extend numerous dendrites into canaliculi less than a micron diameter which are distributed throughout Although osteoclasts the primary bone-resorbing cells, osteocytes also reportedly dissolve hydroxyapatite at peri-lacunar However, robust three-dimensional evidence for peri-canalicular mineral dissolution has been lacking. Here we applied previously reported Talbot-defocus multiscan...
Diabetes mellitus (DM) is frequently accompanied by complications, such as peripheral nerve neuropathy. Schwann cells play a pivotal role in regulating function and conduction velocity; however, changes cell differentiation status DM are not fully understood. Here, we report that de-differentiate into immature under hyperglycemic conditions result of sorbitol accumulation decreased Igf1 expression those cells. We found de-differentiated could be re-differentiated vitro mature treatment with...
Evidence supports that daily and once-weekly administration of teriparatide, human (h)PTH(1–34), enhance bone mass in osteoporotic patients. However, it is uncertain whether different frequencies hPTH(1–34) would induce formation similarly terms quantity quality. To investigate issue, mice were subjected to PTH administration, their bones histologically examined. Frequencies 1 time/2 days, time a day, 2 4 times day. Mice allocated either control or 3 dosing regimens: 80 μg/kg per injection...
Diallyl disulfide (DADs), a natural organic compound, is extracted from garlic and scallion has anti-tumor effects against various tumors. This study investigated the activity of DADs in human osteosarcoma cells mechanisms. MG-63 were exposed to (0, 20, 40, 60, 80, 100 μM) for different lengths time (24, 48, 72 h). The CCK8 assay results showed that inhibited cell viability dose-and time-dependent manner. FITC-Annexin V/propidium iodide staining flow cytometry demonstrated apoptotic ratio...
Abstract To elucidate the effect of evocalcet, a new oral calcimimetic to bone secondary hyperparathyroidism (SHPT) with chronic kidney disease (CKD), rats were 5/6 nephrectomized and fed on high-phosphate diet. The treated then divided into vehicle groups evocalcet administered groups. in exhibited increased levels serum PTH inorganic phosphate (Pi) levels, high turnover, severe cortical porosity, mimicking SHPT (CKD-SHPT rats). CKD-SHPT showed broad demineralization around osteocytes,...
To elucidate the histological events that follow administration of eldecalcitol, a second-generation vitamin D analog currently awaiting approval as drug for treatment osteoporosis, we employed ovariectomy (OVX) rat model. OVX rats received vehicle or 30ng/kg and sham-operated animals only. Rats were sacrificed after 12weeks had their femora tibiae removed processed histochemical histomorphometrical analyses. When compared with group, osteoclastic number bone resorption parameters...
ABSTRACT Activating mutations of calcium-sensing receptor (CaSR) cause autosomal dominant hypocalcemia (ADH). ADH patients develop hypocalcemia, hyperphosphatemia, and hypercalciuria, similar to the clinical features hypoparathyroidism. The current treatment is other forms hypoparathyroidism, using active vitamin D3 or parathyroid hormone (PTH). However, these treatments aggravate hypercalciuria renal calcification. Thus, new therapeutic strategies for are needed. Calcilytics allosteric...
Osteomas are benign tumors composed of mature, compact, or cancellous bone that commonly arise in the sinuses and exhibit slow asymptomatic growth. Surgical resection may be performed using intraoral extraoral approaches when functional morphological deficits present. A 63‐year‐old female presented with an osteoma subcondylar region, which had doubled size 9 years after initial diagnosis. Considering potential risk impairment, was excised high perimandibular approach. Two postsurgery,...
UbiA prenyltransferase domain containing 1 (UBIAD1) is a novel vitamin K2 biosynthetic enzyme screened and identified from the human genome database. UBIAD1 has recently been shown to catalyse biosynthesis of Coenzyme Q10 (CoQ10) in zebrafish cells. To investigate function vivo, we attempted generate mice lacking Ubiad1, homolog UBIAD1, by gene targeting. Ubiad1-deficient (Ubiad1(-/-)) mouse embryos failed survive beyond embryonic day 7.5, exhibiting small-sized body gastrulation arrest....
Oral squamous cell carcinoma (OSCC) refers to the malignant tumor of head and neck with a highest morbidity.It exhibits poor prognosis unsatisfactory treatment partially attributed delayed diagnosis.As indicated from existing reports, protein histidine phosphatase LHPP acts as vital factor in tumorigenesis liver, lung, bladder, breast pancreatic tissues.Thus far, functional mechanism OSCC remains unclear.DGE analysis, lines cases were found that was down-regulated tissues cells compared...
ABSTRACT Vitamin K is a fat-soluble vitamin that necessary for blood coagulation. In addition, it has bone-protective effects. functions as cofactor of γ-glutamyl carboxylase (GGCX), which activates its substrates by carboxylation. These are found throughout the body and examples include hepatic coagulation factors. Furthermore, ligand nuclear receptor known steroid xenobiotic (SXR) murine ortholog, pregnane X (PXR). We have previously reported on role SXR/PXR signaling demonstrating...
Rheumatoid arthritis (RA) is a commonly occurring autoimmune disease. Its defining pathological characteristic the excessive proliferation of fibroblast‑like synoviocytes (FLS), which similar to tumor cells and results in range clinical problems. As used antipyretic, analgesic anti‑inflammatory drug, aspirin first‑line treatment for RA. However, its mechanism action has not been well explained. The goal investigate biological effects on primary RA‑FLS underlying mechanisms. In this...
Summary Intermittent administration of human parathyroid hormone (1-34) (hPTH(1-34)) promotes anabolic action in bone by stimulating remodeling, while eldecalcitol, an analog active vitamin D3, suppresses osteoclastic resorption, and forms new minimodeling. We have examined the biological effects combined eldecalcitol hPTH(1-34) on 9-week-old Wistar rats that underwent ovariectomy (OVX) or Sham operation. They were divided into a group, OVX with vehicle (OVX group), 10 µg/kg/day (PTH 20...