A5069678280- Bone Metabolism and Diseases
- Bone health and treatments
- Orthopaedic implants and arthroplasty
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Bone and Joint Diseases
- Bone health and osteoporosis research
- Vitamin D Research Studies
- Metabolomics and Mass Spectrometry Studies
- Peroxisome Proliferator-Activated Receptors
- Hip disorders and treatments
- Immunotherapy and Immune Responses
- Nerve injury and regeneration
- Total Knee Arthroplasty Outcomes
- Advanced MRI Techniques and Applications
- Axon Guidance and Neuronal Signaling
- Liver physiology and pathology
- Hereditary Neurological Disorders
- Immune cells in cancer
- Rheumatoid Arthritis Research and Therapies
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Orthopedic Infections and Treatments
- Bone Tissue Engineering Materials
Keio University
2012-2024
Shizuoka Red Cross Hospital
2024
Fujita Health University Hospital
2024
Fujita Health University Bantane Hospital
2024
Significance Estrogen deficiency after menopause frequently accelerates osteoclastic bone resorption, leading to osteoporosis, the most common skeletal disorder in women. However, mechanisms underlying osteoporosis resulting from estrogen remain largely unknown. We report a unique mechanism postmenopausal and therapeutic target, hypoxia-inducible factor 1 alpha (HIF1α), treat this condition. HIF1α is unstable presence of oxygen, but stabilized under hypoxic conditions. we found that...
Abstract Cell–cell fusion is a dynamic phenomenon promoting cytoskeletal reorganization and phenotypic changes. To characterize factors essential for of macrophage lineage cells, we identified the multitransmembrane protein, osteoclast stimulatory transmembrane protein (OC-STAMP), analyzed its function. OC-STAMP–deficient mice exhibited complete lack cell–cell osteoclasts foreign body giant cells (FBGCs), both which are macrophage-lineage multinuclear although expression dendritic cell...
Diabetes mellitus (DM) is frequently accompanied by complications, such as peripheral nerve neuropathy. Schwann cells play a pivotal role in regulating function and conduction velocity; however, changes cell differentiation status DM are not fully understood. Here, we report that de-differentiate into immature under hyperglycemic conditions result of sorbitol accumulation decreased Igf1 expression those cells. We found de-differentiated could be re-differentiated vitro mature treatment with...
Abstract Osteoporosis is a complex disease with various causes, such as estrogen loss, genetics, and aging. Here we show that dominant-negative form of aldehyde dehydrogenase 2 (ALDH2) protein, ALDH2*2, which produced by single nucleotide polymorphism (rs671), promotes osteoporosis due to impaired osteoblastogenesis. Aldh2 plays role in alcohol-detoxification acetaldehyde-detoxification; however, transgenic mice expressing Aldh2*2 (Aldh2*2 Tg) exhibited severe increased levels blood...
Chronic inflammation is frequently associated with tumorigenesis in elderly people. By contrast, young people without chronic often develop tumors considered independent of but driven instead by mutations. Thus, whether has a significant role tumor progression mutations remains largely unknown. Here we show that TNFα required for the osteosarcoma, most common children and adolescents. We transplantation AX osteosarcoma cells, which harbor driving c-Myc overexpression Ink4a-deficiency,...
Osteoporosis is a skeletal disorder characterized by compromised bone strength and increased risk of fracture. Low mass and/or pre-existing fragility fractures serve as diagnostic criteria in deciding when to start medication for osteoporosis. Although osteoporosis metabolic disorder, markers predict reduced are unknown. Here, we show serum metabolomics profiles women grouped pre-menopausal with normal mineral density (BMD) (normal estrogen BMD; NN), post-menopausal BMD (low LN) or low LL)...
Abstract Idiopathic osteonecrosis of the femoral head (IONFH) is an ischemic disorder that causes bone necrosis head, resulting in hip joint dysfunction. IONFH a polygenic disease and steroid alcohol have already known to increase its risk; however, mechanism remains be elucidated. We performed genome-wide association study using ~60,000 subjects found two novel loci on chromosome 20q12 12q24. Big data analyses identified LINC01370 as candidate susceptibility gene locus. Stratified analysis...
Although both an active form of the vitamin D metabolite, 1,25(OH)2D3, and analogue, ED71 have been used to treat osteoporosis, anti-bone resorbing activity is reportedly seen only in ED71- but not 1,25(OH)2D3 -treated patients. In addition, how inhibits osteoclast patients has fully characterized. Recently, HIF1α expression osteoclasts was demonstrated be required for development post-menopausal osteoporosis. Here we show that suppress protein vitro. We found or function requires receptor...
Low serum 25-hydroxyvitamin D (25(OH)D) levels are implicated as a risk factor for hip and spine fractures. Studies of the relation between 25(OH)D fractures have primarily involved elderly osteoporosis patients or with fractures; however, parathyroid hormone (PTH) status in younger adult populations remains largely unknown. We evaluated intact PTH 411 women aged 39–64 years who were not receiving medication other bone diseases. Serum positively correlated age (P = 0.019), whereas inversely...
Abstract Resonance frequency analysis (RFA) is valuable for assessing implant status. In a previous investigation, acetabular cup fixation was assessed using laser RFA and the pull‐down force predicted in an vitro setting. While alone sufficient initial evaluation, it desirable to evaluate bone strength of foundation subsequent fixation. Diminished quality causes micromotion, migration, protracted osseointegration, consequently elevating susceptibility periprosthetic fractures failure...
Well leg compartment syndrome (WLCS) is a rare but severe complication after the surgery in lithotomy position. We present case of bilateral WLCS that occurred prolonged urologic A 50-year-old man complained lower pain and swelling sixteen hours surgery. Physical examination, elevated serum creatine kinase value, contrasting computed tomography, pressure strongly suggested development localized anterior lateral compartments. Emergent single-incision fasciotomy was performed four diagnosis....
It has been well documented that labral tear is frequently associated with femoroacetabular impingement and dysplasia of the hip; however, there have few reported cases idiopathic osteonecrosis hip. Here we report case a patient femoral head who was treated by hip arthroscopy, favorable short-term outcome. Under diagnosis systemic lupus erythematosus, 28-year-old Japanese woman oral administration steroid in 2007. A year after treatment, she developed right joint pain diagnosed at our...
Introduction: Venous thromboembolism (VTE) remains a major complication after total hip arthroplasty (THA), irrespective of the surgical approach. This study investigated incidence VTE in patients undergoing THA through intermuscular minimally invasive techniques, which included direct anterior approach (DAA), an anterolateral (AL), and supine (ALS), at single institution. Methods: A hundred consecutive treated with each were evaluated. Plasma D-dimer levels one month preoperatively day...