A5061340890- Bone and Joint Diseases
- Orthopaedic implants and arthroplasty
- Hip disorders and treatments
- Bone health and treatments
- Orthopedic Infections and Treatments
- Bone health and osteoporosis research
- Hip and Femur Fractures
- Total Knee Arthroplasty Outcomes
- Cell Adhesion Molecules Research
- Bone Metabolism and Diseases
- Cerebrovascular and Carotid Artery Diseases
- Shoulder Injury and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Lower Extremity Biomechanics and Pathologies
- Mycobacterium research and diagnosis
- Plant-based Medicinal Research
- Rheumatoid Arthritis Research and Therapies
- Scoliosis diagnosis and treatment
- Galectins and Cancer Biology
- Elbow and Forearm Trauma Treatment
- Advanced MRI Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and genetic disorders
- Berberine and alkaloids research
- Fatty Acid Research and Health
Hokkaido University
2012-2025
NTT Medical Center
2022-2025
Shimizu (Japan)
2020
Teijin (Japan)
2020
Clinical Orthopaedics and Related Research
2018
Sunagawa City Medical Center
2016
Center of Molecular Immunology (Cuba)
2009
Osteopontin is critically involved in rheumatoid arthritis; however, the molecular cross-talk between osteopontin and joint cell components that leads to inflammatory destruction largely unknown. We found not only but also tenascin-C their common receptor, alpha(9) integrin, are expressed at arthritic joints. The local production of mainly due synovial fibroblasts and, a lesser extent, macrophages. Synovial macrophages express autocrine paracrine interactions integrin on its ligands...
Abstract Osteonecrosis of the femoral head (ONFH) often leads to collapse, which makes joint preservation challenging. Although curved varus osteotomy (CVO) is an effective surgical method for in young ONFH patients, there are some cases where it cannot prevent collapse. This research aims evaluate usefulness teriparatide (TPD) bone healing and preventing collapse CVO-treated patients. retrospective study included 48 patients (56 hips) diagnosed with ONFH, categorized into three groups:...
Using the rat middle cerebral artery occlusion model, alterations in eicosanoid synthetic capacity of brain microvessels following ischemia were studied by radiochromatography. Brain normal rats predominantly produced hydroxyacids with relatively small amounts PGD2 and PGE2 from exogenous arachidonic acid. Confirmation that prostaglandins products respectively lipoxygenase(s) cyclooxygenase was obtained experiments using indomethacin eicosatetraynoic The microvessel, especially hydroxyacids,...
Rheumatoid arthritis (RA), a chronic systemic inflammatory disorder that principally attacks synovial joints, afflicts over 2 million people in the United States. Interleukin (IL)-17 is considered to be master cytokine chronic, destructive arthritis. Levels of ganglioside GM3, one most primitive glycosphingolipids containing sialic acid structure, are remarkably decreased synovium patients with RA. Based on increased secretions observed vitro experiments, GM3 might have an immunologic role....
Objective. The role of the joint tissue microenvironment in pathogenesis human RA has recently attracted much attention. present study investigated roles α9β1 integrin and its ligands synovial specimens patients generating unique arthritic microenvironment.
Abstract Background The definitive treatment of borderline-to-mild dysplasia remains controversial. A more comprehensive understanding the etiology osteoarthritis (OA) and clarification any possible association between pathogenesis OA are essential. Questions/purposes (1) Does distribution acetabular subchondral bone density increase according to severity? (2) Is there an pathogenesis? Methods We evaluated bilateral hips patients with developmental hip who underwent eccentric rotational...
Abstract Idiopathic osteonecrosis of the femoral head (IONFH) is an ischemic disorder that causes bone necrosis head, resulting in hip joint dysfunction. IONFH a polygenic disease and steroid alcohol have already known to increase its risk; however, mechanism remains be elucidated. We performed genome-wide association study using ~60,000 subjects found two novel loci on chromosome 20q12 12q24. Big data analyses identified LINC01370 as candidate susceptibility gene locus. Stratified analysis...
Collapse of the femoral head associated with nontraumatic osteonecrosis (NOFH) is one most common causes disability in young adult patients. Excessive bone resorption by osteoclast coincident suppression osteogenesis are believed to be responsible for collapse progression. Alendronate that inhibits inducing apoptosis has been traditionally used treating NOFH; however, several reports documented serious complications use this drug. On other hand, teriparatide activates osteoblasts leading an...
Abstract Background Internal fixation is recommended for treating Vancouver B1 periprosthetic femoral fractures. Although several procedures have been developed with high stability and union rates, long-term weight-bearing constructs are still lacking. Therefore, the aim of present study was to evaluate a double-plate procedure using reversed contralateral locking compression-distal plates fractures under full weight-bearing. Methods Single- were analysed an axial load 1,500 N by finite...
Aim: This study aimed to evaluate the 2-year outcomes from a clinical trial of recombinant human FGF-2 (rhFGF-2) for osteonecrosis femoral head (ONFH). Patients & methods: Sixty-four patients with nontraumatic, precollapse and large ONFHs were percutaneously administered 800 μg rhFGF-2 contained in gelatin hydrogel. Setting end point radiological collapse, we analyzed joint preservation period historical control. Changes two validated scores, bone regeneration safety evaluated. Results:...
Despite good clinical outcomes associated with curved intertrochanteric varus osteotomy for the treatment of osteonecrosis femoral head, post-operative leg-length discrepancy is frequently reported and might reduce patient satisfaction. Although previous report showed that angulation affected discrepancy, sufficient most important factor obtaining a lateral intact portion. Therefore, to ensure better postoperative outcomes, detection other parameters leg shortening may prove useful. This...
The incidence of bilateral corticosteroid-induced osteonecrosis the femoral head (ONFH) is high. Although precise mechanism ONFH development unclear, hepatic enzyme abnormalities such as low activity cytochrome P450 3A could be one cause. Herein, we report case a patient who developed in contralateral hip after dose corticosteroids for idiopathic thrombocytopenic purpura was increased. Liver biopsy done to rule out autoimmune hepatitis. A 32-year-old woman had been treated with continuous up...
Abstract Background There is evidence that the cause of primary osteoarthritis (OA) related to changes in subchondral bone; however, influence insufficiency fracture (SIF) femoral head on degeneration hip joint and prognostic factors remain unclear. The objectives this study were (1) investigate natural history space width after occurrence SIF (2) associations between narrowing bone metabolic markers as well magnetic resonance imaging (MRI) among patients with SIF. Methods Between January...
Purpose Eccentric rotational acetabular osteotomy (ERAO) is a modification of (RAO); it has been reported that ERAO allows the femoral head to translate medially and distally. However, no study compared translation following RAO or ERAO. The purpose this was compare immediate postoperative after in comparison with pre-operative position by radiological methods. Methods Patients treated between 2006 2014 were retrospectively evaluated. 19 hips (17 patients) RAO, 25 (22 roof angle location...