A5024185122- Orthopaedic implants and arthroplasty
- Hip disorders and treatments
- Medical Imaging and Pathology Studies
- Sarcoma Diagnosis and Treatment
- Bone and Joint Diseases
- Bone health and treatments
- Vascular Tumors and Angiosarcomas
- Parathyroid Disorders and Treatments
- Heterotopic Ossification and Related Conditions
- Vascular Anomalies and Treatments
- Cardiac tumors and thrombi
- Bone Metabolism and Diseases
- Radiopharmaceutical Chemistry and Applications
- Cell Adhesion Molecules Research
- Osteomyelitis and Bone Disorders Research
- Radiomics and Machine Learning in Medical Imaging
- Otitis Media and Relapsing Polychondritis
- IgG4-Related and Inflammatory Diseases
- Cancer, Hypoxia, and Metabolism
- Gastrointestinal Tumor Research and Treatment
- Law and Political Science
- Hip and Femur Fractures
- Cancer Diagnosis and Treatment
- Public Administration and Political Analysis
- Bone and Dental Protein Studies
National Hospital Organization Hokkaido Medical Center
2020-2021
Sapporo National Hospital
2020-2021
Hokkaido University
2012-2020
Clinical Orthopaedics and Related Research
2018
Hokkaido University Hospital
2017
Bone metastasis is becoming increasingly common globally. In such cases, cancer cells disseminate from the primary site to bone, subsequently entering a dormant state. Following certain incubation period, reawaken and grow, forming metastatic mass. These are called metastasis-initiating (MICs), but their survival reawakening poorly understood. Here, we established an in vivo MIC-reawakening mouse model bone. Microarray analysis demonstrated enrichment for mitochondrial oxidative...
Abstract Background The definitive treatment of borderline-to-mild dysplasia remains controversial. A more comprehensive understanding the etiology osteoarthritis (OA) and clarification any possible association between pathogenesis OA are essential. Questions/purposes (1) Does distribution acetabular subchondral bone density increase according to severity? (2) Is there an pathogenesis? Methods We evaluated bilateral hips patients with developmental hip who underwent eccentric rotational...
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by renal phosphate wasting, hypophosphatemia, reduction of 1,25-dihydroxyl vitamin D, and bone calcification disorders. Tumors associated with TIO are typically phosphaturic mesenchymal tumors that soft tissue origin often present as solitary tumor. The high production fibroblast growth factor 23 (FGF23) the tumor believed to be causative responsible for impaired tubular reabsorption, hypophosphatemia...
Collapse of the femoral head associated with nontraumatic osteonecrosis (NOFH) is one most common causes disability in young adult patients. Excessive bone resorption by osteoclast coincident suppression osteogenesis are believed to be responsible for collapse progression. Alendronate that inhibits inducing apoptosis has been traditionally used treating NOFH; however, several reports documented serious complications use this drug. On other hand, teriparatide activates osteoblasts leading an...
Abstract Background Hepatic metastasis of soft tissue sarcoma is rare compared to lung metastasis, and the literature scarce. We examined risk hepatic according site occurrence histological type. Methods From a Hospital‐based Cancer Registry, 658 patients registered between 2007 2017 with sarcomas were evaluated. The exclusion criteria gastrointestinal stromal tumors, tumors unknown origin, follow‐up periods less than 1 month. SPSS 25 was used for statistical analysis. Results significantly...
Despite good clinical outcomes associated with curved intertrochanteric varus osteotomy for the treatment of osteonecrosis femoral head, post-operative leg-length discrepancy is frequently reported and might reduce patient satisfaction. Although previous report showed that angulation affected discrepancy, sufficient most important factor obtaining a lateral intact portion. Therefore, to ensure better postoperative outcomes, detection other parameters leg shortening may prove useful. This...
The incidence of bilateral corticosteroid-induced osteonecrosis the femoral head (ONFH) is high. Although precise mechanism ONFH development unclear, hepatic enzyme abnormalities such as low activity cytochrome P450 3A could be one cause. Herein, we report case a patient who developed in contralateral hip after dose corticosteroids for idiopathic thrombocytopenic purpura was increased. Liver biopsy done to rule out autoimmune hepatitis. A 32-year-old woman had been treated with continuous up...
Although smoking history is predictive of poor pulmonary metastasis-free survival (PMFS) in patients with epithelial tumors, the impact on PMFS those soft-tissue sarcoma (STS) not known.Patients undergoing treatment for STS at our institutes between 2008 and 2017 were enrolled. Patients excluded if they had metastatic lesion, or a histopathological classification demonstrating small round-cell sarcoma. The overall was examined multivariate analysis using Cox proportional hazards model.A...
Purpose Eccentric rotational acetabular osteotomy (ERAO) is a modification of (RAO); it has been reported that ERAO allows the femoral head to translate medially and distally. However, no study compared translation following RAO or ERAO. The purpose this was compare immediate postoperative after in comparison with pre-operative position by radiological methods. Methods Patients treated between 2006 2014 were retrospectively evaluated. 19 hips (17 patients) RAO, 25 (22 roof angle location...
Nakayama, Kanako MD; Yamamoto, Sayaka Uetake, Kimiaki MD, PhD; Yamada, Masafumi Tozawa, Yusuke Ueki, Masahiro Takezaki, Shunichiro Nishimura, Hiroki Nakamaru, Yuji Mitsuhashi, Tomoko Oyama-Manabe, Noriko Sakamoto, Keita Arai, Ryuta Ariga, Tadashi PhD Author Information
Good outcomes have been reported in revision total hip replacement with massive segmental defects using impaction bone grafting circumferential metal meshes. However, the morphology of that require a mesh is poorly defined. The purpose this study was to evaluate effects variety on load transmission proximal femur under both axial and rotational loads.Initial stability Exeter stem investigated composite model three medial defect morphologies: Long (length 5 cm × width 2 cm), Short (2.5 Square...