A5101655602- Orthopaedic implants and arthroplasty
- Hip disorders and treatments
- Bone and Joint Diseases
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Osteoarthritis Treatment and Mechanisms
- Hip and Femur Fractures
- Bone health and treatments
- Asthma and respiratory diseases
- Inflammatory mediators and NSAID effects
- Helicobacter pylori-related gastroenterology studies
- Bone Metabolism and Diseases
- Cardiac Valve Diseases and Treatments
- Bone health and osteoporosis research
- Aortic Disease and Treatment Approaches
- Oceanographic and Atmospheric Processes
- Infective Endocarditis Diagnosis and Management
- Gastric Cancer Management and Outcomes
- Lower Extremity Biomechanics and Pathologies
- Geology and Paleoclimatology Research
- Tendon Structure and Treatment
- Intraoperative Neuromonitoring and Anesthetic Effects
- Allergic Rhinitis and Sensitization
- Pelvic and Acetabular Injuries
- Gastroesophageal reflux and treatments
Hokkaido University
2016-2025
Himeji Medical Center
2025
National Hospital Organization
2017-2025
College of Industrial Technology
2024
Nihon University
2024
Hamamatsu University School of Medicine
2012-2024
Hokkaido University Hospital
2021
Fujisawa City Hospital
1997-2020
Teijin (Japan)
2020
Shimizu (Japan)
2020
Objective The severity of osteoarthritis (OA) and cartilage degeneration is highly correlated with the development synovitis, which mediated by activity inflammatory macrophages. A better understanding intercellular communication between macrophages chondrocytes should aid in discovery novel therapeutic targets. We undertook this study to explore pathologic role macrophage extracellular vesicles (EVs) degeneration. Methods Macrophages were stimulated treatment bacterial lipopolysaccharides...
The increased incidence of osteoarthritis (OA), particularly knee and hip OA, osteoporosis (OP), owing to population aging, have escalated the medical expense burden. Osteoarthritis is more prevalent in older women, involvement subchondral bone fragility spotlights its association with OP. Notably, insufficiency fracture (SIF) may represent a pronounced condition OA pathophysiology. This review summarizes relationship between OP, incorporating recent insights into SIF. Progressive SIF leads...
Background: The incidence of developmental dysplasia the hip (DDH) in Japanese newborns has reduced drastically following a primary prevention campaign initiated around 1972 to 1973; this perinatal education promoted maintaining hips naturally flexed-leg position. purpose present study was describe life course epidemiology osteoarthritis (OA) adolescent and adult patients assess its association with exposure for DDH. Methods: We included new OA diagnosed from January 1, 2022, December 31, at...
Objective We evaluated the safety and efficacy of vonoprazan-based amoxicillin clarithromycin 7-day triple therapy (VAC) in comparison to proton pump inhibitor (PPI)-based (PAC) as a first-line treatment metronidazole (VAM) PPI-based (PAM) second-line for eradication Helicobacter pylori Japan.
Abstract There is currently no therapy available for periprosthetic osteolysis, the most common cause of arthroplasty failure. Here, role AnxA1 in osteolysis and potential therapeutics were investigated. Reducing expression calvarial tissue was found to be associated with increased osteolytic lesions induced by debris implantation more severe AnxA1-defecient mice than wild-type mice. inhibits differentiation osteoclasts through suppressing NFκB signaling promoting PPAR-γ pathway....
Background: Developmental dysplasia of the hip (DDH) is a prevalent issue in infants, with ultrasound crucial for early detection. Existing automatic diagnostic models lack precision due to noise, but 3D technology may enhance it. This study aimed create and assess deep-learning-based model automated DDH diagnosis by using transformation on two-dimensional images. Methods: A retrospective 417 infants at risk used images, combining convolutional neural networks image processing. The images...
ABSTRACT Introduction Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a rare autosomal dominant genetic disorder. We report case diagnosed with HLRCC following subcapsular hematoma caused by tumor. Case Presentation A 28‐year‐old woman history of uterine myomas presented left back pain. Computed tomography revealed mass hematoma, coil embolization was performed. The tumor had enlarged rapidly, 18 F‐fluorodeoxyglucose positron emission tomography/computed significant uptake,...
Macrophage migration inhibitory factor (MIF) is a pleiotrophic lymphocyte and macrophage cytokine; it likely to play an important role in innate immunity. Genome-wide search for atopy susceptibility genes recently identified human chromosome 22q11, where the gene encoding MIF resides, as region of interest atopic traits. Both −173G/C −794 [CATT]5–8 repeat polymorphisms promoter are associated with altered levels transcription vitro. We, therefore, hypothesized that these potentially...
We have previously described the mid- to long-term results of conventional simple varus intertrochanteric osteotomy for osteonecrosis femoral head, showing that 19 26 hips had good or excellent results. extended follow-up a mean 18.1 years (10.5 26) including total 34 in 28 patients, with age at surgery 33 (19 53). There were 18 men and ten women 25 (74%) satisfactory result Harris hip score ≥ 80. In all, six needed replacement (THR) hemiarthroplasty. The collapse head narrowing joint space...
Genome-wide association studies (GWAS) have identified >100 risk loci for systemic lupus erythematosus (SLE), but the disease genes at most remain unclear, hampering translation of these genetic discoveries. We aimed to prioritise underlying 110 SLE that were in latest East Asian GWAS meta-analysis.
Both transfibular ankle arthrodesis with fibular onlay grafting and using the Ilizarov apparatus have resulted in acceptable fusion rates. This study analyzed outcomes authors' practice for all patients who underwent apparatus.A retrospective review was conducted of experienced severe pain associated osteoarthritis, rheumatoid arthritis, talar osteonecrosis, or septic arthritis an between 1995 2010. Postoperative clinical were evaluated 42 consecutive (43 feet) received primary revision...
Periprosthetic osteolysis induced by orthopedic implant-wear debris continues to be the leading cause of arthroplasty failure in majority patients. Release wear results a chronic local inflammatory response typified recruitment immune cells, including macrophages. The cellular mediators derived from activated macrophages favor osteoclast-bone resorbing activity resulting bone loss at site implant and loosening prosthetic components. Emerging evidence suggests that chemokines their receptors...
Abstract Background The definitive treatment of borderline-to-mild dysplasia remains controversial. A more comprehensive understanding the etiology osteoarthritis (OA) and clarification any possible association between pathogenesis OA are essential. Questions/purposes (1) Does distribution acetabular subchondral bone density increase according to severity? (2) Is there an pathogenesis? Methods We evaluated bilateral hips patients with developmental hip who underwent eccentric rotational...
Abstract Idiopathic osteonecrosis of the femoral head (IONFH) is an ischemic disorder that causes bone necrosis head, resulting in hip joint dysfunction. IONFH a polygenic disease and steroid alcohol have already known to increase its risk; however, mechanism remains be elucidated. We performed genome-wide association study using ~60,000 subjects found two novel loci on chromosome 20q12 12q24. Big data analyses identified LINC01370 as candidate susceptibility gene locus. Stratified analysis...