A5055735274- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Hip disorders and treatments
- Bone and Joint Diseases
- Hip and Femur Fractures
- Bone Tissue Engineering Materials
- Pelvic and Acetabular Injuries
- Bone Metabolism and Diseases
- Immune cells in cancer
- Synthesis of Organic Compounds
- Neurofibromatosis and Schwannoma Cases
- Facial Trauma and Fracture Management
- Beetle Biology and Toxicology Studies
- Liver physiology and pathology
- Microscopic Colitis
- Renal Diseases and Glomerulopathies
- Craniofacial Disorders and Treatments
- Cancer Research and Treatments
- Tendon Structure and Treatment
- bioluminescence and chemiluminescence research
- Aortic Disease and Treatment Approaches
- Lower Extremity Biomechanics and Pathologies
- Inflammatory Bowel Disease
- Advanced Glycation End Products research
Kyushu University
2011-2025
Stanford University
2014-2020
Orthopaedic Research Laboratories
2014-2020
Aso Iizuka Hospital
2020
Indiana University School of Medicine
2014
Sapporo Medical University
1996-2012
Orthopedic One
2012
Sapporo Medical University Hospital
2006
Background Although a wide variety of acetabular deformities in developmental dysplasia the hip (DDH) have been reported, morphologic features entire pelvis DDH are not well characterized and their correlation with deformity is unknown. Questions/purposes We determined whether there was rotational innominate bone, if so, it related to version coverage. Patients Methods examined using CT for 50 patients (82 hips). Forty normal hips were used as controls. The rotation angle at three levels...
Background: The incidence of developmental dysplasia the hip (DDH) in Japanese newborns has reduced drastically following a primary prevention campaign initiated around 1972 to 1973; this perinatal education promoted maintaining hips naturally flexed-leg position. purpose present study was describe life course epidemiology osteoarthritis (OA) adolescent and adult patients assess its association with exposure for DDH. Methods: We included new OA diagnosed from January 1, 2022, December 31, at...
Background The rotational position of the acetabulum to pelvis (acetabular tilt) may influence acetabular version and coverage femoral head. To date, pathologic significance tilt in hip dysplasia is unknown. Questions/Purposes We determined whether different from that normal hips this correlates with coverage. Methods measured angle on lateral view three-dimensional pelvic CT images 40 patients (72 hips) dysplasia. Forty were used as controls. sector was an index for Results mean increased...
<title>Abstract</title> <bold>Background:</bold> Few reports have focused on major perioperative complications, including periprosthetic femoral fracture (PFF) and stem subsidence in cementless total hip arthroplasty (THA), after standardizing the patient’s background comparing different component design at a single center. Therefore, this study aimed to compare incidence of PFF patients undergoing THA between two types component. <bold>Methods:</bold> Between January 2013 June 2020, 753...
This study aimed to investigate whether the use of CT-based navigation enhances: 1) accuracy cup placement; and 2) achievement rate required range motion (ROM). Additionally, we investigated impact using a large femoral head dual-mobility liner on rates. retrospective analyzed 60 manual 51 navigated primary total hip arthroplasties performed at single facility. Postoperative CT scans simulation software were employed measure orientation simulate ROM. We compared absolute errors for...
Leg length discrepancy (LLD), offset, and anatomical abnormalities such as a high-riding greater trochanter are key factors that may influence the outcomes of total hip arthroplasty (THA). Understanding how these affect patient-reported (PROs) is crucial for optimizing surgical techniques improving patient satisfaction. This study investigated whether preoperative postoperative LLD, PROs in unilateral THA. A questionnaire survey was conducted targeting 1,010 individuals who underwent primary...
Background: Spinopelvic abnormalities have been reported to be a risk factor for dislocation after total hip arthroplasty (THA). This study aimed compare the kinematics of pelvis and joints in patients with without spinopelvic THA elucidate dynamic forward-leaning movement during chair-rising, which are not detectable through static radiographs. Methods: case series included 108 hips that underwent anteroposterior radiographic imaging sit-to-stand motion THA. The average age at surgery was...
Abstract The purpose of this study was to examine the effects ceramic femoral head material, size, and implantation periods on wear annealed, cross‐linked ultra‐high molecular weight polyethylene (UHMWPE) (XLPE) in total hip arthroplasty compared non‐cross‐linked conventional UHMWPE (CPE). XLPE fabricated by cross‐linking with 60 kGy irradiation annealing. Femoral heads made from zirconia alumina ceramics cobalt–chrome (CoCr) 22 or 26 mm diameter were used. In retrospective cohort study,...
Excessive generation of wear particles after total joint replacement may lead to local inflammation and periprosthetic osteolysis. Modulation the key transcription factor NF-κB in immune cells could potentially mitigate osteolytic process. We previously showed that delivery ultrahigh-molecular-weight polyethylene (UHMWPE) recruited osteoprogenitor reduced However, biological effects modulating signaling pathway on osteoprogenitor/mesenchymal stem (MSCs) remain unclear. Here we decoy...
Modulation of macrophage polarization is emerging as promising means to mitigate wear particle-induced inflammation and periprosthetic osteolysis. As a model for continuous local drug delivery, we used miniature osmotic pumps deliver IL-4 in order modulate vitro from nonactivated M0 inflammatory M1 phenotypes towards tissue regenerative M2 phenotype. Pumps delivered into vials containing mouse bone marrow (mBMM) media. This conditioned media (CM) was collected at seven day intervals up four...
Abstract Modulation of macrophage polarization and prevention CCL2‐induced chemotaxis are emerging strategies to reduce wear particle induced osteolysis aseptic total joint replacement loosening. In this study, the effect continuous IL‐4 delivery or bioactive implant coating that constitutively releases a protein inhibitor CCL2 signaling (7ND) on were studied in murine femoral intramedullary infusion model. Polyethylene particles with without infused into mouse distal femurs implanted hollow...
Total joint replacement (TJR) has revolutionized the treatment of end-stage arthritic disorders.
Total joint replacement (TJR) has been widely used as a standard treatment for late-stage arthritis. One challenge long-term efficacy of TJR is the generation ultra-high molecular weight polyethylene wear particles from implant surface that activates an inflammatory cascade which may lead to bone loss, prosthetic loosening and eventual failure procedure. Here, we investigate local administration mutant CCL2 proteins, such 7ND, on reducing particle-induced inflammation osteolysis in vivo...
Macrophages play a key role in tissue homeostasis as well range of pathological conditions including atherosclerosis, cancer, and autoimmunity. Many aspects their vivo behavior are, however, poorly understood. Bioluminescence imaging (BLI) with green fluorescent protein (GFP) firefly luciferase (FLUC) labelled autologous reporter macrophages could potentially offer powerful tool to study macrophage biology, but this approach has been hindered by the relative difficulty efficient gene...
Anteversion of an acetabular component often is difficult to ascertain in patients with THA whom excessively anteverted or retroverted femurs may result limited ROM risk dislocation. Restriction motion, however, determined by the combination version both components.We therefore combined anteversion values that provide adequate ROM. We varied differing implantations and femoral modular necks.ROM was tested changing cup after setting 20° 60° retroversion. The angle neck adjusted 11 increments...
Wear particles induce periprosthetic inflammation and osteolysis through activation of nuclear factor kappa B (NF-κB), which up-regulates the downstream target gene expression for proinflammatory cytokines in macrophages. It was hypothesized that direct suppression NF-κB activity early phases this disorder could be a therapeutic strategy preventing inflammatory response to wear particles, potentially mitigating osteolysis. can suppressed via competitive binding with double stranded decoy...