A5036018761- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Osteoarthritis Treatment and Mechanisms
- Pleural and Pulmonary Diseases
- Spondyloarthritis Studies and Treatments
- Metastasis and carcinoma case studies
- Medical Imaging and Pathology Studies
- Lung Cancer Research Studies
- Head and Neck Cancer Studies
- Autoimmune and Inflammatory Disorders Research
- Congenital Diaphragmatic Hernia Studies
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Plasma Diagnostics and Applications
- Spine and Intervertebral Disc Pathology
- Myasthenia Gravis and Thymoma
- Trauma Management and Diagnosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac tumors and thrombi
- Esophageal and GI Pathology
- Gas Sensing Nanomaterials and Sensors
- Inflammatory mediators and NSAID effects
- Esophageal Cancer Research and Treatment
- Psoriasis: Treatment and Pathogenesis
- Vibration and Dynamic Analysis
Kyoto Prefectural University of Medicine
2019-2025
Showa University Fujigaoka Hospital
2025
Queen's University
2023-2024
Kingston Health Sciences Centre
2023-2024
University Health Network
2015-2024
Krembil Research Institute
2016-2024
Arthritis Foundation
2016-2024
Arthritis Society
2021-2024
Sasebo City General Hospital
2012-2023
Saitama Medical University
2022-2023
The highest efficiency of 24.4% for the solar-to-hydrogen (STH) energy conversion was obtained in an outdoor field test by combining concentrator photovoltaic (CPV) modules with InGaP/GaAs/Ge three-junction cells and polymer-electrolyte electrochemical (EC) cells. high using high-efficiency CPV (∼31% under present operation conditions) direct connection between EC almost optimized number elements series. STH bottleneck clarified to be modules, over-potential cells, matching point...
ObjectivesThis study aimed to identify circulating microRNA (miRNA) signatures in knee synovial fluid (SF) from early-stage and late-stage osteoarthritis (OA) patients.MethodsmiRNAs were screened by miRNA-PCR-arrays validated Real-time quantitative polymerase chain reaction (RT-qPCR) SF (Kellgren–Lawrence (KL): Grade: I/II) OA patients (Grade: III/IV). cartilage or explants cultured the source/release of identified miRNAs. Computational-approach was utilized predict gene/pathway...
We recently identified microRNA-181a-5p (miR-181a-5p) as a critical mediator involved in the destruction of lumbar facet joint (FJ) cartilage. In this study, we tested if locked nucleic acid (LNA) miR-181a-5p antisense oligonucleotides (ASO) could be used therapeutic to limit articular cartilage degeneration.We variety experimental models consisting both human samples and animal FJ knee osteoarthritis (OA) test effects LNA-miR-181a-5p ASO on degeneration. Histopathological analysis including...
Despite advancements in managing autoimmune rheumatic diseases (ARDs) with existing treatments, many patients still encounter challenges such as inadequate responses, difficulty maintaining remission, and side effects. Chimeric Antigen Receptor (CAR) T-cell therapy, originally developed for cancer, has now emerged a promising option cases of refractory ARDs.
We developed a six-axis multi-anvil press, ATSUHIME, for high-pressure and high-temperature in situ time-of-flight neutron powder diffraction experiments. The press has six orthogonally oriented hydraulic rams that operate individually to compress cubic sample assembly. Experiments indicate the can generate pressures up 9.3 GPa temperatures 2000 K using 6-6-type cell assembly, with available volume of about 50 mm(3). Using 6-8-type conditions expand 16 1273 K. Because no guide blocks, there...
Osteoarthritis (OA) of spine (facet joints [FJs]) is one the major causes severe low back pain and disability worldwide. The degeneration facet cartilage a hallmark FJ OA. However, endogenous mechanisms that initiate are unknown, there no disease-modifying therapies to stop In this study, we have identified microRNAs (small noncoding RNAs) as mediators degeneration. We first established cohort patients with varying degrees (control group: normal or mild degeneration; OA moderate...
Macrophage migration inhibitory factor produced by neutrophils worsens spondyloarthritis inducing a pathogenic T H 17 phenotype in regs .
Gamma-aminobutyric acid (GABA) is a non-protein amino and contained in various foods, such as fruits vegetables. Although health benefits of GABA have been reported, seems to unidentified functions. In this study, we first show increase intracellular level GABA-treated breast cancer cell lines, MCF-7 T-47D, analyses immunofluorescence. our experimental condition, treatment reduced estradiol-stimulated growth these lines. addition, performed mouse early induction model system investigate...
Gallbladder cancer (GBC) is a highly aggressive malignancy exhibiting correlation between increased body mass index and risk of developing GBC. In obese individuals, the release free fatty acids from adipose tissue into circulating blood augmented. However, role oleic acid (OA), one most abundant monounsaturated in plasma, GBC cell proliferation has not been determined. this study, we investigated effects OA on cells. We focused G protein-coupled receptor 120/free 4 (GPR120/FFAR4) 40/free 1...
The aim of this study is to experimentally investigate the effect drying on a shear wall, and clarify mechanism changes in structural performance due drying. Two sufficiently hydrated wall specimens are prepared. Then, one loaded without drying, while other tested after sufficient until shrinkage concrete reaches an equi-librium state. results show reduction initial stiffness little change ultimate strength dry specimen, spite increase compressive strength. Reproduction numerical analysis...
Plasma and SiO 2 etching characteristics employing inductively coupled plasma (ICP) were studied with respect to distance from an antenna. Measurement of the ratio electron ion saturation currents in CHF 3 shows increase negative fluorine ions downstream regions. The intensity C (516.5 nm)/F(685.6 nm) also indicates high carbon-concentration region. Further more, addition H 4 F 8 , which has more carbon species, yielded higher /F ratio. Accordingly, it was found that selectivity /Si...
Abstract Background For chronic pain after thoracic surgery, optimal timing of its diagnosis and effective treatment remains unresolved, although several options are currently available. We examined the efficacy safety mirogabalin, in combination with conventional therapy (nonsteroidal anti-inflammatory drugs and/or acetaminophen), for treating peripheral neuropathic (NeP) surgery. Methods In this multicenter, randomized, open-label, parallel-group study, patients NeP were randomly assigned...
Minitablets have garnered interest as a new paediatric formulation that is easier to swallow than liquid formulations. In Japan, besides the latter, fine granules are frequently used for children. We examined swallowability of multiple drug-free minitablets and compared it with formulations in 40 children two age groups (n = 20 each, aged 6-11 12-23 months). percentage who could without chewing or leftover. The visited department Showa University Hospital were enrolled. Their caregivers...
Three-dimensionally integrated micro-solution plasmas (3D IMSPs), in which microplasmas are generated gas bubbles an aqueous solution held a porous dielectric material, have been applied to gold nanoparticle synthesis. Conventional plasma processes require additional chemicals increase the electrical conductivity of for generating plasmas. In contrast this, 3D IMSPs found generate without such procedure when has low as case HAuCl 4 The synthesis confirmed through observation optical...
Protein lactylation is a post-translational modification associated with glycolysis. Although recent evidence indicates that protein involved in epigenetic gene regulation, its pathophysiological significance remains unclear, particularly neoplasms. Herein, we investigated the potential involvement of molecular mechanisms underlying benign and malignant pancreatic epithelial tumors, as well role response cancer (PC) cells to gemcitabine. Increased was observed nuclei intraductal papillary...
We compared the results of bronchoplasty and with pulmonary angioplasty (broncho-angioplasty). Multivariate analysis was done to determine potential prognostic factors for both procedures based on our 20-year single-center experience.Between January 1985 December 2004, 163 bronchoplastic were in 1405 patients who underwent lung resections cancer at Nagasaki University Hospital. After excluding 16 carino-plasty patients, 147 (118 29 broncho-angioplasty) included.In group, postoperative...