A5074006316- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Lung Cancer Treatments and Mutations
- Tissue Engineering and Regenerative Medicine
- Pleural and Pulmonary Diseases
- Transplantation: Methods and Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Surgical Simulation and Training
- Neonatal Respiratory Health Research
- Gastric Cancer Management and Outcomes
- Myasthenia Gravis and Thymoma
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Pathology Studies
- Mesenchymal stem cell research
- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Colorectal Cancer Treatments and Studies
- Anatomy and Medical Technology
- RNA modifications and cancer
- Thyroid and Parathyroid Surgery
- Airway Management and Intubation Techniques
- Lung Cancer Research Studies
- Colorectal Cancer Surgical Treatments
- Esophageal and GI Pathology
Nagasaki University
2016-2025
Nagasaki University Hospital
2017-2024
Sasebo City General Hospital
2024
The University of Tokyo
2024
Suita Municipal Hospital
2016
Kansai University
2016
Faculty (United Kingdom)
2016
Bioengineering Center
2016
Kagoshima Immaculate Heart University
2015
Japan Advanced Institute of Science and Technology
2010-2012
Abstract Mechanisms that regulate regional epithelial cell diversity and pathologic remodeling in airways are poorly understood. We hypothesized differences composition injury-related tissue result from the type of local progenitors. used surface markers spatial expression pattern an SFTPC-GFP transgene to subset progenitors by airway region. Green fluorescent protein (GFP) ranged undetectable high a proximal-to-distal gradient. GFPhi cells were subdivided CD24 staining into alveolar...
Currently, most of the artificial airway organs still require scaffolds; however, such scaffolds exhibit several limitations. Alternatively, use an autologous trachea without foreign materials and immunosuppressants may solve these issues constitute a preferred tool. The rationale this study was to develop new scaffold-free approach for using bio-3D printing technology. Here, we assessed circumferential tracheal replacement trachea-like grafts generated from isolated cells in inbred animal...
Matsumoto, Keitaro, Kengo Ishihara, Kazunori Tanaka, Kazuo Inoue, and Tohru Fushiki. An adjustable-current swimming pool for the evaluation of endurance capacity mice. J. Appl. Physiol. 81(4): 1843–1849, 1996.—A new forced-swimming apparatus determining maximum time in mice was devised use Std ddY CDF1 after various diet drug treatments. With apparatus, a water current is generated by circulating with pump pool. A spout suction slit were contrived to generate constant while strength...
Air spaces of the mammalian lung are lined by a specialized epithelium that is maintained endogenous progenitor cells. Within bronchioles, abundance and distribution cells contribute to epithelial homeostasis change as function maintenance versus repair. It unclear whether functionally distinct pools or single cell type maintain how behavior regulated in normal disease states. To address these questions, we applied fractionation methods for enrichment distal airway progenitors. We show...
Abstract Current scaffold‐based tissue engineering approaches are subject to several limitations, such as design inflexibility, poor cytocompatibility, toxicity, and post‐transplant degradation. Thus, scaffold‐free tissue‐engineered structures can be a promising solution overcome the issues associated with classical materials in clinical transplantation. The present study seeks optimize culture conditions cell combinations used generate using Bio‐3D printing system. Human cartilage cells,...
Bioengineered lungs consisting of a decellularized lung scaffold that is repopulated with patient's own cells could provide desperately needed donor organs in the future. This approach has been tested rats, and partially explored porcine human lungs. However, existing bioengineered are fragile, part because their immature vascular structure. Herein, we report application adipose-derived stem/stromal (ASCs) for engineering pulmonary vasculature rat scaffold. We found pre-seeded ASCs...
Various strategies have been attempted to replace esophageal defects with natural or artificial substitutes using tissue engineering. However, these methods not yet reached clinical application because of the high risks related their immunogenicity insufficient biocompatibility. In this study, we developed a scaffold-free structure mixture cell types bio-three-dimensional (3D) printing technology and assessed its characteristics in vitro vivo after transplantation into rats. Normal human...
Epigenetic parameters such as DNA methylation and histone modifications play pivotal roles in carcinogenesis. Global modification patterns have been implicated possible predictors of cancer recurrence prognoses a great variety tumor entities. Our study was designed to evaluate the association among trimethylated H3 at lysine 27 (H3K27me3), clinicopathological variables outcome early-stage non-small cell lung (NSCLC). The expression H3K27me3 its methyltransferase, enhancer zeste homolog 2...
Sargramostim, a recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) inhalation therapy, was recently approved for pharmaceutical use in Japan and shows promise as treatment autoimmune pulmonary alveolar proteinosis (APAP). For APAP patients with severe respiratory failure due to advanced lung fibrosis, transplantation is also option; however, may recur after the procedure. Here, we report case of successful sargramostim therapy post-transplant relapse patient who...
Background/Aim: In pancreatic cancer, gemcitabine and EGFR tyrosine kinase inhibitors (EGFR-TKIs) are common chemotherapy options. Reports have shown that EGFR-TKIs suppress the expression of thymidine synthase (TS), an important enzyme for DNA biosynthesis, increase sensitivity to in lung cancer. However, no such reports been made Materials Methods: Human cancer cell lines MiaPaCa2, Panc1, BxPc3 were used. TS mRNA protein levels cells analyzed after erlotinib treatment. addition, anti-tumor...
ABSTRACT This case highlights the possibility that Immunoglobulin G4‐related disease (IgG4‐RD) lesions can also occur in sternoclavicular joint. If a neoplastic lesion is found joint, biopsy should be attempted to diagnose IgG4‐RD as differential.
To elucidate the molecular basis of muscle atrophy, we have performed serial analysis gene expression (SAGE) method with control and immobilized muscles 10 rats. The genes that expressed >0.5% in are involved following three functions: 1) contraction (troponin I, C T; myosin light chain 1-3; actin; tropomyosin; parvalbumin), 2) energy metabolism (cytochrome c oxidase I III, creatine kinase, glyceraldehyde-3-phosphate-dehydrogenase, phosphoglycerate mutase, ATPase 6, aldolase A), 3)...
The number of elderly lung cancer patients requiring surgery has been increasing due to the ageing society and less invasive perioperative procedures. Elderly people usually have various comorbidities, but there are few simple objective tools that can be used determine prognostic factors for with clinical stage I non-small-cell (NSCLC). aim this retrospective study was evaluate surgically treated, over 80-year old NSCLC.The preoperative data 97 NSCLC were collected at Nagasaki University...
Lung transplantation is the last option for treatment of end stage chronic lung disorders. Because shortage donor organs represents main hurdle, regeneration has been considered to overcome this hurdle. Recellularization decellularized organ scaffold a promising regeneration. Although detergents are ordinarily used decellularization, other approaches possible. Here we high alkaline (pH12) sodium hydroxide (NaOH)-PBS solution without decellularization and compared efficacy on DNA elimination...
The aim of the present study was to investigate prognostic value C-reactive protein-to-albumin ratio (CAR) and compare it with other inflammation-based scores (Glasgow score, modified Glasgow neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte nutritional index index) in patients esophageal squamous cell cancer (ESCC). A database 116 primary ESCC who underwent treatment at Division Surgical Oncology Nagasaki University Hospital between January 2007 August 2014 retrospectively reviewed...