A5059253184- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Medical Imaging and Pathology Studies
- Sarcoidosis and Beryllium Toxicity Research
- Occupational exposure and asthma
- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- Pleural and Pulmonary Diseases
- Occupational and environmental lung diseases
- Inhalation and Respiratory Drug Delivery
- Sarcoma Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Myasthenia Gravis and Thymoma
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Genetic factors in colorectal cancer
- Photodynamic Therapy Research Studies
- Atrial Fibrillation Management and Outcomes
- Endometrial and Cervical Cancer Treatments
- MRI in cancer diagnosis
- Meningioma and schwannoma management
- Cancer Immunotherapy and Biomarkers
- Cervical Cancer and HPV Research
Kagoshima University
2008-2025
Katsushika Medical Center
2025
Naha City Hospital
2017-2024
Nagasaki University
2013-2023
Nagasaki University Hospital
2013-2020
Memorial Sloan Kettering Cancer Center
2017-2019
Toyama University Hospital
2016
Tokyo Gas (Japan)
2003
Abstract There has been a dramatic increase in the detection of lung nodules, many which are preneoplasia atypical adenomatous hyperplasia (AAH), adenocarcinoma situ (AIS), minimally invasive (MIA) or (ADC). The molecular landscape and evolutionary trajectory have not well defined. Here, we perform multi-region exome sequencing 116 resected nodules including AAH (n = 22), AIS 27), MIA 54) synchronous ADC 13). Comparing to AIS, ADC, observe progressive genomic evolution at single nucleotide...
Abstract The mechanism by which anti-cancer immunity shapes early carcinogenesis of lung adenocarcinoma (ADC) is unknown. In this study, we characterize the immune contexture invasive ADC and its precursors transcriptomic profiling, T cell receptor (TCR) sequencing multiplex immunofluorescence (mIF). Our results demonstrate that anti-tumor evolved as a continuum from preneoplasia, to preinvasive ADC, minimally-invasive frankly with gradually less effective more intensively regulated response...
<i>Objectives:</i> MUC16 carries the peptide epitope CA125, which is well known as a marker of ovarian cancer. High serum levels (CA125) have been reported not only in patients with cancer but also liver diseases. We evaluated expression intrahepatic cholangiocarcinoma-mass forming type (ICC-MF) tissues. <i>Methods:</i> examined by immunohistochemical analyses using monoclonal antibody M11 ICC-MF tissues from 63 patients. To compare prevalence each mucin...
Programmed cell death ligand-1 (PD-L1) expression may predict the response to both programmed death-1 and PD-L1 inhibitors in lung cancer. However, extent of intratumoral heterogeneity expression, which cause false negative results, is largely unexplored. We aimed assess surgically resected cancer specimens by applying a novel method tissue microarray, namely Spiral Arrays, enables us observe spiral-shaped cores. Adenocarcinoma squamous carcinoma were obtained from consecutive patients with...
Several reports have demonstrated the use of whole‐slide imaging (WSI) for primary pathological diagnosis, but no such studies been published from Asia. We retrospectively collected 1070 WSI specimens 900 biopsies and small surgeries conducted in nine hospitals. Nine pathologists, who participated this study, trained College American Pathologists guidelines, reviewed made diagnoses based on digitized, 20× or 40× optically magnified images with a scanner. After washout interval over 2 weeks,...
Recent statistics on lung cancer, including the steady decline of advanced diseases and dramatically increasing detection early-stage indeterminate pulmonary nodules, mark significance a comprehensive understanding early carcinogenesis. Lung adenocarcinoma (ADC) is most common histologic subtype atypical adenomatous hyperplasia only recognized preneoplasia to ADC, which may progress in situ (AIS) minimally invasive (MIA) eventually ADC. Although molecular evolution during carcinogenesis has...
Background: Transbronchial lung cryobiopsy (TBLC) has a high incidence of adverse events. This study aimed to investigate the relationship between occurrence these events and condition pathology samples or pathological diagnosis in TBLC. Methods: We studied 102 patients who underwent TBLC for interstitial disease. analyzed association TBLC-related events, including hemorrhage, pneumothorax, acute exacerbation Results: The occurred 19 (18.6%), which hemorrhage was most common (14 patients,...
Thoracic endovascular aortic repair (TEVAR) is a minimally invasive treatment for descending thoracic aneurysms, especially in high-risk patients; however, vascular access can be difficult cases with small or calcified femoral arteries. Herein, we report case of an 82-year-old woman aneurysm who underwent TEVAR using abdominal approach because inadequate access. A synthetic graft was anastomosed to the aorta provide secure conduit deployment stent graft. The procedure successfully completed...
Thoracic diseases in patients with systemic lupus erythematosus (SLE), especially interstitial pneumonia (SLE-IP), are rare and have been poorly studied. The aims of this multicentre study were to evaluate SLE-IP elucidate its clinical characteristics prognosis. Fifty-five who had attended the respiratory departments participating hospitals retrospectively evaluated study. Clinical information, high-resolution computed tomography (HRCT), surgical lung biopsy/autopsy specimens analysed by...
The reporting of tumour cellularity in cancer samples has become a mandatory task for pathologists. However, the estimation is often inaccurate. Therefore, we propose collaborative workflow between pathologists and artificial intelligence (AI) models to evaluate lung protocol apply it routine practice.We developed quantitative model adenocarcinoma that was validated tested on 50 cases, where could access AI results adjust their original scores (adjusted-score) 151 cases. adjusted-score by...
Background Patients with idiopathic interstitial pneumonia (IIP) have a favourable prognosis when they autoimmune features (IPAF). However, precise IPAF-related findings from high-resolution computed tomography (HRCT) and lung histopathological specimens the treatment response not been fully determined. Therefore, this study was conducted to evaluate relationship between on HRCT or progression of in patients IPAF. Methods This multicentre cohort prospectively enrolled consecutive IIP. At...
This study was designed to investigate the use of time-dependent diffusion magnetic resonance imaging (MRI) parameters in distinguishing between glioblastomas and brain metastases.
The establishment of whole-slide imaging (WSI) as a medical diagnostic device allows that pathologists may evaluate mitotic activity with this new technology. Furthermore, the image digitalization provides an opportunity to develop algorithms for automatic quantifications, ideally leading improved reproducibility compared naked eye examination by pathologists. In order implement them effectively, accuracy figure detection using WSI should be investigated. study, we aimed measure pathologist...
It is often difficult to histologically differentiate among endometrial dedifferentiated carcinoma (DC), endometrioid (EC), serous (SC), and carcinosarcoma (CS) due the presence of solid components. In this study, we aimed categorize these carcinomas according The Cancer Genome Atlas (TCGA) classification using a small custom-made cancer genome panel (56 genes 17 microsatellite regions) for integrated molecular diagnosis. A total 36 cases with components were assessed IHC, next-generation...
Context.— The accurate identification of different lung adenocarcinoma histologic subtypes is important for determining prognosis but can be challenging because overlaps in the diagnostic features, leading to considerable interobserver variability. Objective.— To provide an overview agreement among pathologists and create a ground truth using clustering approach downstream computational applications. Design.— Three sets images with evaluation levels (small patches, areas relatively uniform...
Abstract Background Increasing evidence indicates the utility of transbronchial lung cryobiopsy (TBLC) for diagnosis interstitial disease (ILD). However, only one study has compared TBLC and surgical biopsy (SLB) performed on same patients. Methods We identified seven patients with ILD SLB. evaluated clinical characteristics made a pathological based official ATS/ERS/JRS/ALAT practice guideline idiopathic pulmonary fibrosis both Results Six cases were diagnosed as Usual pneumonia (UIP) in...
Abstract The human AlkB homolog family (ALKBH) of proteins play a critical role in some types cancer. However, the expression and function lysine demethylase ALKBH4 cancer are poorly understood. Here, we examined non-small-cell lung (NSCLC) found that was highly expressed NSCLC, as compared to adjacent normal tissues. knockdown significantly induced downregulation NSCLC cell proliferation via cycle arrest at G 1 phase vivo tumour growth. downregulated E2F transcription factor (E2F1) its...
Genomic examination of cytology specimens is often performed on cell blocks or conventional smears rather than liquid-based (LBC) specimens. Since LBC preserve high-quality DNA, cancer genome profiling using next-generation sequencing (NGS) also attainable from residual One the advantages for NGS that it allows direct extraction DNA specimens, avoiding a sacrifice smear slides and minimizing genomic processing time.Endometrial were subjected to analysis validate practicality rapid in...