A5045294195- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Kidney Disease and Diabetes
- Metabolism and Genetic Disorders
- Advanced Glycation End Products research
- Systemic Sclerosis and Related Diseases
- Dialysis and Renal Disease Management
- Occupational and environmental lung diseases
- Cancer Immunotherapy and Biomarkers
- Renal Diseases and Glomerulopathies
- Lung Cancer Treatments and Mutations
- Nitric Oxide and Endothelin Effects
- Renin-Angiotensin System Studies
- Inflammatory Myopathies and Dermatomyositis
- Pharmacological Effects and Toxicity Studies
- Diabetes Treatment and Management
- Diet and metabolism studies
- Pleural and Pulmonary Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Medical Imaging and Pathology Studies
- Occupational exposure and asthma
- Eosinophilic Disorders and Syndromes
- Lung Cancer Diagnosis and Treatment
- IgG4-Related and Inflammatory Diseases
- Pharmacogenetics and Drug Metabolism
- Cardiovascular Issues in Pregnancy
JA Shizuoka Koseiren ENSHU hospital
2013-2025
Tokyo University of Agriculture and Technology
2025
Kurume University
2015-2024
Hamamatsu University School of Medicine
2006-2012
Pediatric Nephrology of Alabama
2008
Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is a recently reported group of disorders characterized by fibrotic thickening the pleural and subpleural parenchyma predominantly in upper lobes. We report five Japanese cases fulfilling criteria IPPFE address whether it should be considered separate clinicopathologic entity. And this study was an attempt to identify features common between previously described idiopathic lobe fibrosis (IPUF), allowing as distinct entity our series.Five...
Advanced glycation end products (AGEs) and their receptor (RAGE) play a role in diabetic nephropathy. We screened DNA aptamer directed against AGEs (AGEs-aptamer) vitro examined its effects on renal injury KKAy/Ta mice, an animal model of type 2 diabetes. Eight-week-old male or C57BL/6J mice received continuous intraperitoneal infusion AGEs- control-aptamer for 8 weeks. AGEs-aptamer was detected level increased the kidney at least 7 days. The elimination half-lives were about Compared with...
Food or supplement-derived L-carnitine is changed to trimethylamine (TMA) by interstinal microbiota, which further metabolized trimethylamine-N-oxide (TMAO), being involved in the promotion of atherosclerosis animal models. Meanwhile, carnitine deficiency has played a role accelerated hemodialysis (HD) patients. However, effects oral supplementation on circulating levels TMAO and markers vascular injury oxidative stress patients HD remain unclear. In this study, we addressed issue.Thirty-one...
Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, plays a role in endothelial dysfunction, initial step of atherosclerosis. Advanced glycation end products (AGEs) also contribute to accelerated However, pathophysiological crosstalk between ADMA and AGEs remains unclear. In this study, we investigated the relationship AGE level patients with end-stage renal disease (ESRD) due diabetic nephropathy. We examined whether how increased generation by cultured cells...
Matrix metalloproteinase-2 (MMP-2) is responsible for the degradation of various types extracellular matrix (ECM) proteins such as type IV collagen. Decreased MMP-2 expression and activity has been generally thought to contribute increased accumulation ECM at advanced stage diabetic nephropathy. However, kinetics role in early phase nephropathy remain unclear. To address this issue, we examined whether streptozotocin (STZ)-induced was accelerated knockout (KO) mice. Diabetes induced by...
Abstract Background Lipids have immunomodulatory functions and the potential to affect cancer immunity. Methods The associations of pretreatment serum cholesterol long-chain fatty acids with objective response rate (ORR), progression-free survival (PFS), overall (OS) were evaluated in 148 patients non-small cell lung who received nivolumab. Results When each lipid was separately evaluated, increased low-density lipoprotein (LDL)-cholesterol ( P < 0.001), high-density (HDL)-cholesterol =...
ABSTRACT Background and objective The efficacy of combination therapy with corticosteroids CNI, TAC CsA, for PM/DM‐ILD has been described retrospectively. However, it remains unknown which CNI treatment regimens, or CsA are more effective as initial treatments patients PM/DM‐ILD. Methods We conducted a prospective multicentre, open‐label, randomized, 52‐week phase 2 trial. Patients were randomly allocated to receive PSL plus (TAC group) (CsA group). primary endpoint was PFS rate in the...
Background Patients with idiopathic interstitial pneumonia (IIP) have a favourable prognosis when they autoimmune features (IPAF). However, precise IPAF-related findings from high-resolution computed tomography (HRCT) and lung histopathological specimens the treatment response not been fully determined. Therefore, this study was conducted to evaluate relationship between on HRCT or progression of in patients IPAF. Methods This multicentre cohort prospectively enrolled consecutive IIP. At...
Abstract Background Toll‐like receptor 2 (TLR2) in keratinocytes can be activated by Staphylococcus spp. that are frequently detected on the skin of dogs with atopic dermatitis (AD). C‐C motif chemokine ligand 5 (CCL5) produced has been considered to involved pathogenesis canine AD (cAD). However, whether TLR2 activation induces CCL5 production remains unclear. Hypothesis/Objectives To elucidate effect agonists keratinocytes, possible synergy interferon (IFN)‐γ, interleukin (IL)‐13 or IL‐4...
Background and objective: Acute exacerbations of interstitial pneumonias (IP) can occasionally occur, have an extremely poor prognosis. Recently, direct haemoperfusion with a polymyxin B immobilized fibre column (PMX‐DHP) was shown to beneficial effect in acute IPF. However, little is known about the efficacy PMX‐DHP other IP. This study investigated effectiveness safety Methods: The subjects consisted five patients exacerbation IP, including three IPF, one idiopathic pneumonia (IIP)...
Ischemia/reperfusion injury is the leading cause of acute tubular necrosis. Nitric oxide has a protective role against ischemia/reperfusion injury; however, asymmetric dimethylarginine (ADMA), an endogenous inhibitor nitric synthase, in remains unclear. ADMA produced by protein arginine methyltransferase (PRMT) and mainly degraded dimethylaminohydrolase (DDAH). Here we examined kinetics PRMT DDAH expression kidneys ischemia/reperfusion-injured mice. After injury, DDAH-1 levels were decreased...
The pathological appearance of idiopathic pleuroparenchymal fibroelastosis (IPPFE) with hematoxylin-eosin staining is similar to that usual interstitial pneumonia (UIP) in patients pulmonary fibrosis (IPF). amount elastic fibers (EF) and detailed differences between IPPFE IPF have not been fully elucidated. aim this study was quantify the EF identify IPF. We evaluated six 28 who underwent surgical lung biopsy or autopsy. patients' clinical history, physical findings, chest high-resolution...
<h3>Importance</h3> Robust predictors for response to anti–programmed death 1 and its ligand (PD-1/PD-L1) immunotherapy in non–small cell lung cancer (NSCLC) are not fully characterized. <h3>Objective</h3> To evaluate whether<i>PD-L1</i>(<i>CD274</i>) copy number gains (CNGs), comprising amplification polysomy, pretreatment specimens assessed by fluorescence situ hybridization associated with nivolumab monotherapy NSCLC. <h3>Design, Setting, Participants</h3> This multicenter cohort study...
<b><i>Background:</i></b> Idiopathic pleuroparenchymal fibroelastosis (PPFE) is a rare form of idiopathic interstitial pneumonia that characterized by predominantly upper lobe pleural and subpleural lung parenchymal fibrosis. Pneumothorax one the major respiratory complications in PPFE patients; however, its clinical features are poorly understood. <b><i>Objective:</i></b> We aimed to investigate complication pneumothorax patients with PPFE....