A5069180309- Asthma and respiratory diseases
- Cancer Immunotherapy and Biomarkers
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immunotherapy and Immune Responses
- Aortic Disease and Treatment Approaches
- Immune cells in cancer
- Aortic aneurysm repair treatments
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Gallbladder and Bile Duct Disorders
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Hepatitis C virus research
- Pneumonia and Respiratory Infections
- Cardiac Arrhythmias and Treatments
- Central Venous Catheters and Hemodialysis
- Nanoplatforms for cancer theranostics
- Pancreatic and Hepatic Oncology Research
- Advanced MRI Techniques and Applications
- Tuberculosis Research and Epidemiology
Okayama University
2024-2025
Okayama University Hospital
2025
Shizuoka General Hospital
2015-2024
Keio University
2017-2024
Massachusetts General Hospital
2022-2024
Harvard University
2022-2024
Higashihiroshima Medical Center
2005-2024
Suzuki (Japan)
2023
Tokyo Women's Medical University Hospital
2018-2023
Kanazawa University
2023
Abstract Immune checkpoint blockade combined with antiangiogenic therapy induces vascular normalization and antitumor immunity is efficacious in hepatocellular carcinoma (HCC); but whether how initial immunotherapy affects the efficacy of subsequent are unknown. We evaluated a cohort HCC patients (n = 25) who received pan–vascular endothelial growth factor receptor multikinase inhibitor sorafenib after an antiprogrammed cell death protein (PD)–1 antibody found superior outcomes these (12%...
Tumor-draining lymph nodes (TDLNs) are important for tumor antigen–specific T cell generation and effective anticancer immune responses. However, TDLNs often the primary site of metastasis, causing suppression worse outcomes. Through cross-species single-cell RNA-Seq analysis, we identified features defining cancer heterogeneity, plasticity, evasion during breast progression node metastasis (LNM). A subset cells in exhibited elevated MHC class II (MHC-II) gene expression both mice humans....
Dysbiotic microbiota contributes to the pathogenesis of Crohn's disease (CD) by regulating immune system. Although pro-inflammatory microbes are probably enriched in small intestinal (SI) mucosa, most studies have focused on fecal microbiota. This study aimed examine jejunal and ileal mucosal specimens from patients with CD via double-balloon enteroscopy. Comparative microbiome analysis revealed that composition SI mucosa differs non-CD controls, an increased population several families,...
The forced oscillation technique (FOT) is a noninvasive method with which to measure respiratory system resistance (Rrs) and reactance (Xrs) at wide range of frequencies during breathing rest in short time. purpose this study was assess the differences Rrs Xrs between patients chronic obstructive pulmonary disease (COPD) asthma using new FOT colored 3-dimensional visualization.Fifty-one stable COPD 49 controlled or partly were enrolled. Whole-breath within-breath changes measured compared...
Clinical application of the forced oscillation technique (FOT) has progressed with spread commercially available FOT devices. The correlation between respiratory impedance and spirometry been reported; however, association airway inflammation pulmonary function, in lung periphery particular, is unclear.To assess whether associated peripheral dysfunction asthma.Subjects included 78 patients overall controlled asthma. We measured whole-breath or within-breath system resistance (Rrs) reactance...
<p>This file contains all the supplementary figures and tables related to this manuscript.</p>
<div>Abstract<p>Patient selection for cancer immunotherapy requires precise, quantitative readouts of biomarker expression in intact tumors that can be reliably compared across multiple subjects over time. The current clinical standard assessing response is PD-L1 expression, typically quantified using IHC. This method, however, only provides snapshots status microscopic regions <i>ex vivo</i> specimens. Although various targeted probes have been investigated...
<p>Supplementary Figure S6</p>
<div>Abstract<p>Immune checkpoint inhibitors have revolutionized the treatment of unresectable hepatocellular carcinoma (HCC), but their impressive efficacy is seen in just a fraction patients. One key mechanism immunotherapy resistance paucity dendritic cells (DC) liver malignancies. In this study, we tested combination blockade PD-1 and CXCR4, receptor for CXCL12, pleiotropic factor that mediates immunosuppression tumors. Using orthotopic grafted autochthonous HCC models with...
<p>Supplementary Figure S8</p>
<p>Supplementary Figure S4</p>
<p>Supplementary FIgure S2</p>
<p>Supplementary Figure S7</p>
<p>Supplementary Figure S1</p>
<p>Supplementary Figure S5</p>
<p>Supplementary Figure S9</p>
<p>Supplementary Methods</p>