A5060120280- Medical Imaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Lipid metabolism and disorders
- Apelin-related biomedical research
- Cancer, Hypoxia, and Metabolism
- Alzheimer's disease research and treatments
- Pancreatic and Hepatic Oncology Research
- Protein Tyrosine Phosphatases
- Sulfur Compounds in Biology
- Cancer Cells and Metastasis
- Enzyme Structure and Function
- Memory and Neural Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Redox biology and oxidative stress
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
- Cancer Risks and Factors
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine Tumor Research Advances
- Metabolism, Diabetes, and Cancer
- Gut microbiota and health
- Diet and metabolism studies
- Radiopharmaceutical Chemistry and Applications
Massachusetts Institute of Technology
2024
UCLouvain
2017-2021
Walloon Excellence in Lifesciences and Biotechnology
2019-2021
Abstract The amyloid precursor protein (APP) modulates synaptic activity, resulting from the fine tuning of excitatory and inhibitory neurotransmission. GABAergic neurotransmission is affected by modifications in intracellular chloride concentrations regulated Na + -K -2Cl − cotransporter 1 (NKCC1) neuronal K -Cl 2 (KCC2), allowing entrance efflux chloride, respectively. Modifications NKCC1 KCC2 expression during maturation cortical cells induce a shift signaling. Here, we demonstrated that...
Abstract Epidemiological studies have shown that obese subjects an increased risk of developing triple‐negative breast cancer (TNBC) and overall reduced survival. However, the relation between obesity TNBC remains difficult to understand. We hypothesize apelin, adipokine whose levels are in obesity, could be a major factor contributing both tumour growth metastatization patients. observed development under high‐fat diet tumour‐bearing mice significantly growth. By showing no effect...
Abstract Obesity is a known factor increasing the risk of developing breast cancer and reducing disease free survival. In addition to these well-documented effects, recent studies have shown that obesity also affecting response chemotherapy. Among multiple dysregulations associated with obesity, increased level apelin adipokine has been recently be directly involved in association between progression. this study, we analyzed retrospective cohort 62 patients impact tumoral expression on...
Abstract Nearly all melanoma patients with a BRAF‐activating mutation will develop resistance after an initial clinical benefit from BRAF inhibition (BRAFi). The aim of this work is to evaluate whether metabolic imaging using hyperpolarized (HP) 13 C pyruvate can serve as marker early response BRAFi in melanoma, by exploiting the effects BRAFi. Mice bearing human xenografts were treated vemurafenib or vehicle. In vivo HP magnetic resonance spectroscopy was performed at baseline and 24 hours...
Abstract Cancer metastasis is a major contributor to patient morbidity and mortality 1 , yet the factors that determine organs where cancers can metastasize are incompletely understood. In this study, we quantify absolute levels of over 100 nutrients available across multiple tissues in mice investigate how relates ability breast cancer cells grow different organs. We engineered with broad metastatic potential be auxotrophic for specific assessed their colonize then asked tumor growth...
Optimal head and neck squamous cell carcinoma (HNSCC) patient selection for anti-EGFR-based therapy remains an unmet need since only a minority of patients derive long-term benefit from cetuximab treatment. We assessed the ability state-of-the-art noninvasive in vivo metabolic imaging to probe shift cetuximab-sensitive -resistant HNSCC patient-derived tumor xenografts (PDTXs).Three models selected based on their known sensitivity (cetuximab-sensitive or acquired-resistant HNC007 PDTXs,...
Abstract Metastases arise from a subset of cancer cells that disseminate the primary tumor; however, factors contribute to proliferation in secondary site are incompletely understood. The ability thrive new tissue is influenced by genetic and epigenetic changes important for disease initiation progression, but these alone do not predict if where cancers metastasize. Specific types metastasize consistent subsets tissues, suggesting associated with tumor influence environments can grow. Using...
The ability of certain cancer cells to maintain a highly reduced intracellular environment is correlated with aggressiveness and drug resistance. Since the glutathione (GSH) thioredoxin (TRX) systems cooperate tight regulation ROS in cell physiology, stimulation tumour initiation progression, modulation GSH TRX pathways are emerging as new potential targets cancer. In vivo methods assess changes redox status critically needed relevance redox-targeted agents. current study assesses vitro...
Abstract Acetate is reported as a regulator of fat mass but also lipogenic source for cancer cells. Breast surrounded by adipose tissue and has been associated with obesity. However, whether acetate contributes to cell metabolism substrate and/or changing storage eventually obesity‐induced breast progression remains unknown. Therefore, we studied the contribution progression. In vitro, found that not bioenergetic under normoxia did result in significant change growth. using lipidomic...
Event Abstract Back to Cortical cells reveal APP as a regulator of GABAergic neurotransmission Anna Doshina1, Florian Gourgue1, Michiho Onizuka1, Remi Opsomer1, Peng Wang1, Kunie Ando2, Bernadette Tasiaux1, Ilse Dewachter1, Pascal Kienlen-Campard1, Jean-Pierre Brion2, Philippe Gailly1, Jean-Noël Octave1* and Nathalie Pierrot1 1 Université Catholique de Louvain, Belgium 2 Libre Bruxelles, Besides its involvement in the pathophysiology Alzheimer Disease (AD), amyloid precursor protein (APP)...
Abstract Obese subjects present higher risk of developing mammary tumors, worse disease free survival and altered response to neoadjuvant chemotherapy (NAC). The circulating levels the apelin adipokines are increased in obese associated with poorer prognosis cancer patients. In this study, we showed that obesity tumoral expression two factors incomplete NAC breast