A5000373816- Cytokine Signaling Pathways and Interactions
- Cardiac Fibrosis and Remodeling
- interferon and immune responses
- Atherosclerosis and Cardiovascular Diseases
- Viral Infections and Immunology Research
- Cardiovascular Disease and Adiposity
- Pharmacological Effects of Natural Compounds
- Pulmonary Hypertension Research and Treatments
- Medicinal Plant Pharmacodynamics Research
- Signaling Pathways in Disease
- Angiogenesis and VEGF in Cancer
- Immune Cell Function and Interaction
- Nuclear Receptors and Signaling
- Aortic Disease and Treatment Approaches
- Peptidase Inhibition and Analysis
- Cell Adhesion Molecules Research
- Aortic aneurysm repair treatments
- Whipple's Disease and Interleukins
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Effects of Exercise
- Transplantation: Methods and Outcomes
- MicroRNA in disease regulation
- Hormonal Regulation and Hypertension
- Fibroblast Growth Factor Research
- Heat shock proteins research
Kurume University
2014-2024
Cardiovascular Institute Hospital
2007-2015
University of California, San Diego
2001-2011
Japan Science and Technology Agency
2011
Keio University
2011
Harbin Medical University
2011
Kyushu University
2006-2007
Fukuoka University
2007
Charité - Universitätsmedizin Berlin
2006
Sungkyunkwan University
2006
Atherosclerosis is an inflammatory vascular disease responsible for the first cause of mortality worldwide. Recent studies have clearly highlighted critical role immunoinflammatory balance in modulation development and progression. However, immunoregulatory pathways that control atherosclerosis remain largely unknown. We show loss suppressor cytokine signaling (SOCS) 3 T cells increases both interleukin (IL)-17 IL-10 production, induces antiinflammatory macrophage phenotype, leads to...
Cytokines play essential roles in innate and adaptive immunity. However, excess cytokines or dysregulation of cytokine signaling will cause a variety diseases, including allergies, autoimmune inflammation, cancer. Most utilize the so-called Janus kinase-signal transducers activators transcription pathway. This pathway is negatively regulated by various mechanisms suppressors (SOCS) proteins. SOCS proteins bind to JAK receptors, thereby suppressing further events. Especially, suppressor...
Background The Janus family of protein tyrosine kinases (JAKs) regulate cellular processes involved in cell growth, differentiation and transformation through their association with cytokine receptors. We have recently identified the JAK‐binding protein, JAB that inhibits various cytokine‐dependent JAK signalling pathways. JAK2 kinase activity by binding to domain (JH1 domain) N‐terminal inhibitory region (KIR) SH2 domain. has been shown bind phosphorylated Y1007 activation loop JH1. also...
The cytokine-inducible SH2 protein-3 (CIS3/SOCS-3/SSI-3) has been shown to inhibit the JAK/STAT pathway and act as a negative regulator of fetal liver erythropoiesis. Here, we studied molecular mechanisms by which CIS3 regulates erythropoietin (EPO) receptor (EPOR) signaling in erythroid progenitors Ba/F3 cells expressing EPOR (BF-ER). binds directly well JAK2 inhibits EPO-dependent proliferation STAT5 activation. We have identified region containing Tyr(401) cytoplasmic domain direct...
N G , -dimethyl- l -arginine (ADMA) is an endogenously synthesized nitric oxide (NO) synthase inhibitor which has potent pressor/vasoconstrictor effects. Dimethylargininase metabolizes ADMA to -citrulline and plays a key role in determining the vivo levels of ADMA. To investigate pathogenesis hypertension, we measured 24-hour urinary excretion (UADMA) nitrate/nitrite (NOx) Dahl salt-sensitive hypertensive rats spontaneously (SHR). In salt-resistant rats, high-salt diet (8% NaCl) did not...
Suppressor of cytokine signaling 1 (SOCS1) is an important negative regulator for cytokines; however, the role SOCS1 in Th17 differentiation has not been clarified. We generated T cell-specific SOCS1-deficient mice and found that these were extremely resistant to a Th17-dependent autoimmune disease model, experimental encephalomyelitis. naive CD4(+) cells predominantly differentiated into Th1 poorly vitro. These phenotypes canceled IFN-gamma(-/-) background, suggesting large amount IFN-gamma...
Transplantation of endothelial cells (ECs) is a promising therapeutic approach for ischemic disorders. In addition, the generation ECs has become increasingly important providing vascular plexus to regenerated organs, such as liver. Although many attempts have been made generate from pluripotent stem and nonvascular cells, minimum number transcription factors that specialize in directly inducing remains undefined. Here, by screening 18 are both hematopoietic development, we demonstrate ets...
The gp130 cytokine receptor activates a cardiomyocyte survival pathway during the transition to heart failure following biomechanical stress of pressure overload. Although activation is observed transiently transverse aortic constriction (TAC), its mechanism inactivation largely unknown in cardiomyocytes. We show here that suppressor signaling 3 (SOCS3), an intrinsic inhibitor JAK, shows biphasic induction response TAC. SOCS3 was closely correlated with STAT3 phosphorylation, as well...
Abstract —In cultured vascular smooth muscle cells (VSMCs), Janus kinases (JAKs) and signal transducers activators of transcription (STATs) are expressed constitutively play a role in angiotensin II (Ang II)–induced intracellular signaling proliferation. However, little is known regarding the relevance these proteins to process remodeling. The JAK STAT remodeling their functional coupling with Ang were examined balloon-injured rat carotid artery. Immunoreactive Jak2, Tyk2, Stat1, Stat3 not...