A5076485253- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Weed Control and Herbicide Applications
- Biological Control of Invasive Species
- Photonic and Optical Devices
- Cancer, Hypoxia, and Metabolism
- Advanced Fiber Optic Sensors
- Ship Hydrodynamics and Maneuverability
- Allelopathy and phytotoxic interactions
- Semiconductor Lasers and Optical Devices
- Seed Germination and Physiology
- Atherosclerosis and Cardiovascular Diseases
- Cholesterol and Lipid Metabolism
- Advanced Fiber Laser Technologies
- Mitochondrial Function and Pathology
- Kruppel-like factors research
- Ecology and Conservation Studies
- Circular RNAs in diseases
- Exercise and Physiological Responses
- Marine Ecology and Invasive Species
- Inflammasome and immune disorders
- Insect and Pesticide Research
- Radioactive contamination and transfer
- Cardiovascular Function and Risk Factors
Brigham and Women's Hospital
2022-2024
Nagoya University
2012-2023
Niigata University Medical and Dental Hospital
2023
Misato Junshin General Hospital
2021
Okayama University
2006-2019
East Japan Railway (Japan)
2017-2018
Tachikawa Hospital
2017
Asahi Glass (Belgium)
2013
Boston University
2012
Osaka University
1996-2011
Background— Acute coronary syndrome is a leading cause of death in developed countries. Follistatin-like 1 (FSTL1) myocyte-derived secreted protein that upregulated the heart response to ischemic insult. Here, we investigated therapeutic impact FSTL1 on acute cardiac injury small and large preclinical animal models ischemia/reperfusion dissected its molecular mechanism. Methods Results— Administration human significantly attenuated myocardial infarct size mouse or pig model...
Rationale: Physical exercise provides benefits for various organ systems, and some of systemic effects are mediated through modulation muscle-derived secreted factors, also known as myokines. Myonectin/C1q (complement component 1q)/TNF (tumor necrosis factor)-related protein 15/erythroferrone is a myokine that upregulated in skeletal muscle blood by exercise. Objective: We investigated the role myonectin myocardial ischemic injury. Methods Results: Ischemia-reperfusion myonectin-knockout...
Obesity is a major risk factor for the development of insulin resistance and type 2 diabetes. Adipose tissue secretes various bioactive molecules, referred to as adipokines, whose dysregulation can mediate changes in glucose homeostasis inflammatory responses. Here, we identify C1qdc2/CTRP12 an insulin-sensitizing adipokine that abundantly expressed by fat tissues designate this adipolin (adipose-derived factor). Adipolin expression adipose plasma was reduced rodent models obesity. also...
Obesity is closely associated with the progression of vascular disorders, including atherosclerosis and postangioplasty restenosis. C1q/TNF-related protein (CTRP) 9 an adipocytokine that down-regulated in obese mice. Here we investigated whether CTRP9 modulates neointimal hyperplasia smooth muscle cell (VSMC) proliferation vivo vitro. Left femoral arteries wild-type (WT) mice were injured by a steel wire. An adenoviral vector expressing (Ad-CTRP9) or β-galactosidase as control was...
Obesity is a risk factor for cardiovascular disease. C1q/tumor necrosis factor-related protein 9 (CTRP9) an adipokine that downregulated by obesity. We investigated the role of CTRP9 in cardiac injury with loss-of-function genetic manipulations and defined receptor-mediated signaling pathway downstream this adipokine. CTRP9-knockout (CTRP9-KO) mice at age 12 weeks were indistinguishable from wild-type (WT) under basal conditions. CTRP9-KO had exacerbated contractile left ventricle...
Obesity is associated with the development of atherosclerosis. We previously demonstrated that omentin a circulating adipokine downregulated in association atherosclerotic diseases. Here, we examined impact on atherosclerosis gain-of-function genetic manipulations and dissected its potential mechanism. Apolipoprotein E-deficient (apoE-KO) mice were crossed transgenic expressing human gene (OMT-Tg) fat tissue to generate apoE-KO/OMT-Tg mice. ApoE-KO/OMT-Tg exhibited significant reduction...
It is well-established that exercise diminishes cardiovascular risk, but whether humoral factors secreted by muscle confer these benefits has not been conclusively shown. We have shown the protein follistatin-like 1 (Fstl1) beneficial actions on cardiac and endothelial function. However, role of muscle-derived Fstl1 in proliferative vascular disease remains largely unknown. Here, we investigated modulates remodelling response to injury. The targeted ablation led an increase neointimal...
Obesity is highly linked with the development of vascular diseases. Omentin a circulating adipokine that downregulated in patients cardiovascular In this study, we investigated role omentin regulation remodeling response to injury. Wild-type (WT) mice were treated intravenously adenoviral vectors encoding human (Ad-OMT) or control β-gal and subjected arterial wire Ad-OMT treatment reduced neointimal thickening frequencies bromodeoxyuridine-positive proliferating cells injured arteries....
Methylobacterium species are ubiquitous α-proteobacteria that reside in the phyllosphere and fed by methanol is emitted from plants. In this study, we applied whole-cell matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis (WC-MS) to evaluate diversity of collected a variety The WC-MS spectrum was reproducible through two weeks cultivation on different media. peaks M. extorquens strain AM1 cells were attributed ribosomal proteins, but those not also found. We...
Heart disease contributes to the progression of CKD. tissue produces a number secreted proteins, also known as cardiokines, which participate in intercellular and intertissue communication. We recently reported that follistatin-like 1 (Fstl1) functions cardiokine with cardioprotective properties. Here, we investigated role cardiac Fstl1 renal injury after subtotal nephrectomy. Cardiac-specific Fstl1-deficient (cFstl1-KO) mice wild-type were subjected (5/6) cFstl1-KO showed exacerbation...
Secreted factors produced by adipose tissue are involved in the pathogenesis of cardiovascular disease. We previously identified adipolin, also known as C1q/TNF-related protein 12, an insulin-sensitizing adipokine. However, role adipolin vascular disease remains unknown. Here, we investigated whether modulates pathological remodelling.Adipolin-knockout (APL-KO) and wild-type (WT) mice were subjected to wire-induced injury femoral artery. APL-KO showed increased neointimal thickening after...
Starch forms transparent grains, referred to as starch grains (SGs), in amyloplasts. Despite the simple glucose polymer composition of starch, SGs exhibit different morphologies depending on plant species, especially endosperm family Poaceae. In previous comprehensive work, SG Poaceae were classified into four types: compound bimodal uniform and a mixed configuration comprised grains. these observations, phylogenetic relationships among types remained unclear. this report, we analyzed...
Obese states characterized by chronic inflammation are closely linked to the development of metabolic dysfunction. We identified adipolin/CTRP12 as an insulin-sensitizing and anti-inflammatory adipokine. Although obese conditions down-regulate adipolin expression, its molecular mechanism is largely unknown. Here we show that transcriptional regulator Krüppel-like factor (KLF) 15 involved in regulation expression adipocytes. White adipose tissue from diet-induced (DIO) mice showed decreased...
Strategies to promote revascularization are valuable for ischemic cardiovascular disease. Although C1q/TNF-related protein (CTRP) 9 is an adiponectin paralog with protective properties against cardiometabolic disorders, the role of endogenous CTRP9 in endothelial function largely unknown. This study aimed investigate effects on processes and dissected potential mechanisms. CTRP9-knockout (KO) wild-type (WT) mice were subjected unilateral hindlimb surgery. CTRP9-KO exhibited impaired blood...
輸入穀物に由来する海外からの雑草種子の非意図的導入とその耕地への拡散が大きな問題となっている。1993∼95年にかけて鹿島港に入港したムギ類，ナタネ等冬作穀物中の混入雑草種子を調査した。21科92種が識別された。81種群，29検体を対象とした除歪対応分析による序列化の結果，アメリカ合衆国産，カナダ産，ヨーロッパ産（ドイツおよびフィンランド），オーストラリア産の調査検体がそれぞれ特徴的な混入種組成を有することが判明した。アブラナ類が最多の25検体から検出され，シロザが23，カラスムギが21，ソバカズラが20，エノコログサおよびタデ類が18，グンバイナズナが17検体から検出された。アブラナ類は5ヶ国全ての検体に混入しており，北米，特にカナダ産検体への混入数が多かった。高緯度産（カナダ，ヨーロッパ）検体には日本の温暖地以西では夏生一年草である草種が混入していた。生産国の主要雑草種と検体中の混入草種とはおおむね一致した。日本でも近年ムギ作の難防除雑草となっているカラスムギ，ライグラス類は輸入ムギ類に大量に混入していること，また生産国における輪作作物の自生雑草化に由来すると考えられるアブラ...
Summary form only given. Long-period fiber gratings (LPFGs) have recently been attracting much attention for their possible applications such as gain-flattening filters erbium-doped amplifiers. Most LPFGs written in germanosilicate optical fibers because periodic structures can be easily obtained using UV-induced refractive-index changes due to the photosensitivity of Ge-related glass defects. This technique requires that should contain photosensitive sites, and thus it cannot applied those...