A5061409218- Adipokines, Inflammation, and Metabolic Diseases
- Parkinson's Disease Mechanisms and Treatments
- Frailty in Older Adults
- Coronary Interventions and Diagnostics
- Heart Failure Treatment and Management
- Nutrition and Health in Aging
- Cardiac Imaging and Diagnostics
- Adipose Tissue and Metabolism
- Acute Myocardial Infarction Research
- Restless Legs Syndrome Research
- Electrolyte and hormonal disorders
- Dementia and Cognitive Impairment Research
- Cardiovascular Disease and Adiposity
- Visual perception and processing mechanisms
- Cancer and Skin Lesions
- Viral-associated cancers and disorders
- Acute Kidney Injury Research
- Dental Health and Care Utilization
- Neurological disorders and treatments
- Cancer, Hypoxia, and Metabolism
- Sleep and Wakefulness Research
- Dysphagia Assessment and Management
- Cardiac Fibrosis and Remodeling
- Inflammatory Biomarkers in Disease Prognosis
- Diabetes, Cardiovascular Risks, and Lipoproteins
Anjo Kosei Hospital
2016-2025
Nagoya University
2011-2020
GTx (United States)
2019-2020
Tosei General Hospital
2020
Ichinomiya Municipal City Hospital
2020
Ogaki Municipal Hospital
2020
Kansai Medical University
1988-2017
Tottori University
2007-2016
Juntendo University
2015
In-Q-Tel
2013
In 1000 primary gastric carcinomas, 70 (7.0%) contained Epstein-Barr virus (EBV) genomic sequences detected by PCR and Southern blots. The positive tumors comprised 8 of 9 (89%) undifferentiated lymphoepithelioma-like 27 476 (5.7%) poorly differentiated adenocarcinomas, 35 515 (6.8%) moderately to well-differentiated adenocarcinomas. situ EBV-encoded small RNA 1 hybridization hematoxylin/eosin staining in adjacent sections showed that the EBV was present every carcinoma cell but not...
Background— Acute coronary syndrome is a leading cause of death in developed countries. Follistatin-like 1 (FSTL1) myocyte-derived secreted protein that upregulated the heart response to ischemic insult. Here, we investigated therapeutic impact FSTL1 on acute cardiac injury small and large preclinical animal models ischemia/reperfusion dissected its molecular mechanism. Methods Results— Administration human significantly attenuated myocardial infarct size mouse or pig model...
Rationale: Physical exercise provides benefits for various organ systems, and some of systemic effects are mediated through modulation muscle-derived secreted factors, also known as myokines. Myonectin/C1q (complement component 1q)/TNF (tumor necrosis factor)-related protein 15/erythroferrone is a myokine that upregulated in skeletal muscle blood by exercise. Objective: We investigated the role myonectin myocardial ischemic injury. Methods Results: Ischemia-reperfusion myonectin-knockout...
Obesity is closely associated with the progression of vascular disorders, including atherosclerosis and postangioplasty restenosis. C1q/TNF-related protein (CTRP) 9 an adipocytokine that down-regulated in obese mice. Here we investigated whether CTRP9 modulates neointimal hyperplasia smooth muscle cell (VSMC) proliferation vivo vitro. Left femoral arteries wild-type (WT) mice were injured by a steel wire. An adenoviral vector expressing (Ad-CTRP9) or β-galactosidase as control was...
Abstract To assess the prevalence and clinical significance of restless legs syndrome (RLS) in a Japanese population, we carried out community‐based survey rural area Japan. We sent questionnaires requesting information on demographics, Center for Epidemiological Studies Depression scale, Short Form‐8, Pittsburgh Sleep Quality Index, National Institutes Health/International RLS Study Group (IRLSSG) consensus questionnaire, IRLSSG severity scale (IRLS) to 5,528 eligible adult residents town...
Obesity is associated with the development of atherosclerosis. We previously demonstrated that omentin a circulating adipokine downregulated in association atherosclerotic diseases. Here, we examined impact on atherosclerosis gain-of-function genetic manipulations and dissected its potential mechanism. Apolipoprotein E-deficient (apoE-KO) mice were crossed transgenic expressing human gene (OMT-Tg) fat tissue to generate apoE-KO/OMT-Tg mice. ApoE-KO/OMT-Tg exhibited significant reduction...
Obesity is associated with an increased risk of cardiovascular disease. C1q/TNF-related protein (CTRP)-1 a poorly characterized adipokine that up-regulated in association ischemic heart We investigated the role CTRP1 myocardial ischemia injury. CTRP1-knockout mice showed infarct size, cardiomyocyte apoptosis, and proinflammatory gene expression after I/R compared wild-type (WT) mice. In contrast, systemic delivery attenuated damage WT Treatment cardiomyocytes led to reduction...
It is well-established that exercise diminishes cardiovascular risk, but whether humoral factors secreted by muscle confer these benefits has not been conclusively shown. We have shown the protein follistatin-like 1 (Fstl1) beneficial actions on cardiac and endothelial function. However, role of muscle-derived Fstl1 in proliferative vascular disease remains largely unknown. Here, we investigated modulates remodelling response to injury. The targeted ablation led an increase neointimal...
Obesity is highly linked with the development of vascular diseases. Omentin a circulating adipokine that downregulated in patients cardiovascular In this study, we investigated role omentin regulation remodeling response to injury. Wild-type (WT) mice were treated intravenously adenoviral vectors encoding human (Ad-OMT) or control β-gal and subjected arterial wire Ad-OMT treatment reduced neointimal thickening frequencies bromodeoxyuridine-positive proliferating cells injured arteries....
Heart disease contributes to the progression of CKD. tissue produces a number secreted proteins, also known as cardiokines, which participate in intercellular and intertissue communication. We recently reported that follistatin-like 1 (Fstl1) functions cardiokine with cardioprotective properties. Here, we investigated role cardiac Fstl1 renal injury after subtotal nephrectomy. Cardiac-specific Fstl1-deficient (cFstl1-KO) mice wild-type were subjected (5/6) cFstl1-KO showed exacerbation...
In order to determine the prevalence of dementia and mild cognitive impairment (MCI), we conducted a population-based study in Japan.Participants included 924 subjects aged 65 years or older who resided town Ama-cho. phase 1 study, Mini-Mental State Examination Clinical Dementia Rating were administered for screening purposes. 2 screened positive further examined by neurologists. MCI diagnosed means DSM-IV International Working Group on criteria, respectively.By date June 1, 2010, 24 had...
Obesity is linked with an increased risk of lymphedema, which a serious clinical problem. Adiponectin circulating adipokine that down-regulated in obese states. We investigated the effects adiponectin on lymphatic vessel formation model lymphedema and dissected its mechanisms.A mouse was created via ablation tail surface network. Adiponectin-knockout mice showed greater diameter injured compared wild-type mice, associated lower numbers endothelial cells (LECs). Systemic delivery reduced...
Hospitalization for heart failure (HF) carries a risk of impairment in physical activity. We assessed the association between changes Barthel index (BI) during hospitalization and prognosis patients with acute HF. Methods Results: evaluated BI 256 HF at time hospital admission (pre-BI) discharge (post-BI). All were followed 1 year after discharge. significantly decreased enrolled patients. Patients post-BI <60 had longer stays higher rates non-home discharge, lower 1-year survival rate than...
Objective Obesity is a major risk factor for cardiovascular disease. Recent evidence demonstrates that dysregulation of fat-derived hormones, also known as adipokines, linked with the pathogenesis obesity-related disorders including coronary artery disease (CAD). Here, we investigated whether circulating level an adipokine C1q/TNF-related protein (CTRP) 1 associated prevalence CAD. Methods and Results Consecutive 76 male CAD patients were enrolled from inpatients underwent angiography. Sixty...