A5003232811- Electrolyte and hormonal disorders
- Atrial Fibrillation Management and Outcomes
- Adipose Tissue and Metabolism
- Aortic aneurysm repair treatments
- Nutrition and Health in Aging
- Cardiac Arrhythmias and Treatments
- Fibroblast Growth Factor Research
- Ion Transport and Channel Regulation
- Muscle Physiology and Disorders
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Cardiovascular Disease and Adiposity
- Peroxisome Proliferator-Activated Receptors
- Pharmacological Effects and Toxicity Studies
- Microbial metabolism and enzyme function
- Silymarin and Mushroom Poisoning
- Vascular anomalies and interventions
- Dialysis and Renal Disease Management
- Education, Innovation and Language Studies
- Frailty in Older Adults
- Geotechnical Engineering and Soil Mechanics
- Intracerebral and Subarachnoid Hemorrhage Research
- Stroke Rehabilitation and Recovery
- Reliability and Agreement in Measurement
- Poisoning and overdose treatments
Anjo Kosei Hospital
2015-2025
Nagoya University
2020-2025
National Institute for Land and Infrastructure Management
2020
To maintain and restore skeletal muscle mass function is essential for healthy aging. We have found that myonectin acts as a cardioprotective myokine. Here, we investigate the effect of on atrophy in various male mouse models dysfunction. Disruption exacerbates age-associated, sciatic denervation-induced or dexamethasone (DEX)-induced models. Myonectin deficiency also contributes to exacerbated mitochondrial dysfunction reduces expression biogenesis-associated genes including PGC1α...
Abstract Chronic kidney disease is a life‐threatening worldwide. PPARα crucial transcriptional regulator of lipid metabolism and inflammation. Here, we examine whether novel selective modulator, pemafibrate modulates renal injury in model unilateral ureteral obstruction (UUO). Administration to wild‐type (WT) mice led reduction dysfunction fibrosis after UUO with accompanying increases plasma levels fibroblast growth factor (FGF) 21 ketone body β‐hydroxybutyrate (BHB). Treatment WT FGF21 or...
We assessed the long-term safety and efficacy of tolvaptan in 102 patients with heart failure (HF) chronic kidney disease (CKD). Median follow-up duration was 1.6 years (1.0-4.4 years).Methods Results:One patient discontinued because hypernatremia. There were no changes renal function or electrolytes during 1-year follow-up. The cardiac-related death-free HF-related hospitalization-free survival rate significantly higher receiving than propensity score-matched who did not receive...
Cardiovascular disease is a leading cause of death worldwide. Obesity-related metabolic disorders including dyslipidemia impaired collateralization under ischemic conditions, thereby resulting in exacerbated cardiovascular dysfunction. Pemafibrate novel selective PPARα modulator, which has been reported to improve atherogenic dyslipidemia, particular, hypertriglyceridemia and low HDL-cholesterol. Here, we investigated whether pemafibrate modulates the revascularization process mouse model...
Abdominal aortic aneurysm (AAA) is an increasing and life-threatening disease. Obesity contributes to increased risk of AAA. Omentin a circulating adipokine, which downregulated in obese complications. Here, we examined whether omentin could modulate angiotensin (Ang) II-induced AAA formation apolipoprotein E-knockout (apoE-KO) mice.apoE-KO mice were crossed with transgenic expressing the human gene fat tissue (OMT-Tg mice) generate apoE-KO/OMT-Tg mice. apoE-KO subjected continuous Ang II...
Although chronic kidney disease (CKD) is a major health problem worldwide, its underlining mechanism incompletely understood. We previously identified adipolin as an adipokine which provides benefits for cardiometabolic diseases. Here, we investigated the role of in development CKD. Adipolin-deficiency exacerbated urinary albumin excretion, tubulointerstitial fibrosis and oxidative stress remnant kidneys mice after subtotal nephrectomy through inflammasome activation. Adipolin positively...
Abstract Background Mushroom poisoning caused by the ingestion of Russula subnigricans has been reported to cause rhabdomyolysis and cardiac dysfunction, leading death. There have few reports cardiogenic shock induced mushroom that was successfully treated using mechanical circulatory support devices. Case Summary A 38-year-old man presented with gastrointestinal symptoms a day after consuming curry made forest-collected mushrooms admitted diagnosis rhabdomyolysis. Despite appropriate fluid...
Background Myocardial infarction (MI) is a leading cause of death worldwide. We previously identified adipolin, also known as C1q/Tnf-related protein 12, an anti-inflammatory adipokine with protective features against metabolic and vascular disorders. Here, we investigated the effect adipolin on myocardial remodeling in mouse model MI. Methods Male adipolin-knockout (APL-KO) wild-type (WT) mice were subjected to permanent ligation left anterior descending coronary artery create Results...
Chronic kidney disease (CKD) is an increasing and life-threatening worldwide. Recent evidence indicates that blood coagulation factors promote renal dysfunction in CKD patients. Activated factor X (FXa) inhibitors are safe first-line drugs for the prevention of thrombosis patients with atrial fibrillation. Here, we investigated therapeutic effects edoxaban on using mouse 5/6 nephrectomy model. Eight-week-old wild-type mice were subjected to surgery randomly assigned two groups, or vehicle...
Intramyocardial dissecting hematoma is a rare but potentially fatal complication of myocardial infarction. The decision to adopt surgical or conservative strategy may depend on the clinical and hemodynamic stability patients. Regardless, precise temporal assessment structure imperative. We herein report first case patient with early spontaneous remission intramyocardial successfully managed by approach multimodality imaging.
本研究では，低応力下においても顕著な破砕性を示す火山灰質粗粒土の力学特性に及ぼす凍結融解作用の影響を検討するために，実地盤で生じる凍結融解現象を三軸室内で再現可能な試験機を新たに開発し，火山灰質粗粒土の三軸圧縮試験と保水性試験を行った．その結果，非凍上性の火山灰質粗粒土でも破砕性を有する場合には，凍結融解作用により粒子破砕が生じ，融解時に体積収縮する結果，密度が増加するにも関わらずピーク強度は低下し，保水性は高まった．したがって，積雪寒冷地にある火山灰質粗粒土の力学特性の検討には，粒子破砕特性に及ぼす凍結融解作用の影響を評価する必要があることを示した．
Background: Chronic kidney disease (CKD) is associated with poor prognosis in patients undergoing percutaneous coronary intervention (PCI). Urinary neutrophil gelatinase-associated lipocalin (NGAL) a biomarker for renal injury. However, the association between urinary NGAL concentrations and cardiovascular events CKD PCI has not been elucidated. This study investigated clinical impact of on outcomes non-dialysis PCI.