A5041987541- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Cardiac Fibrosis and Remodeling
- Lipid metabolism and disorders
- Biomarkers in Disease Mechanisms
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Function and Risk Factors
- Muscle Physiology and Disorders
- Peroxisome Proliferator-Activated Receptors
- Regulation of Appetite and Obesity
- Blood properties and coagulation
- Fibroblast Growth Factor Research
- Metabolism, Diabetes, and Cancer
- Apelin-related biomedical research
- GDF15 and Related Biomarkers
- Mitochondrial Function and Pathology
- TGF-β signaling in diseases
- Cardiomyopathy and Myosin Studies
- Cancer, Lipids, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Signaling Pathways in Disease
- Tissue Engineering and Regenerative Medicine
- Lipoproteins and Cardiovascular Health
Nagoya University
2016-2025
Boston University
2007-2016
Juntendo University
2015
The University of Texas Southwestern Medical Center
2014
Osaka University
1999-2013
Advanced Science Research Center
2003-2013
Aichi Medical University
2013
Boston Medical Center
2010-2012
University Medical Center
2012
University Medical Center Hamburg-Eppendorf
2011
Abstract —Adiponectin is a novel, adipose-specific protein abundantly present in the circulation, and it has antiatherogenic properties. We analyzed plasma adiponectin concentrations age- body mass index (BMI)–matched nondiabetic type 2 diabetic subjects with without coronary artery disease (CAD). Plasma levels of CAD were lower than those (6.6±0.4 versus 7.9±0.5 μg/mL men, 7.6±0.7 11.7±1.0 women; P <0.001). The patients (4.0±0.4 6.6±0.4 μg/mL, <0.001 men; 6.3±0.8 women). In contrast,...
Among the many adipocyte-derived endocrine factors, we recently found an adipocyte-specific secretory protein, adiponectin, which was decreased in obesity. Although obesity is associated with increased cardiovascular mortality and morbidity, molecular basis for link between vascular disease has not been fully clarified. The present study investigated whether adiponectin could modulate endothelial function relate to coronary disease.For vitro study, human aortic cells (HAECs) were...
Background —Among the many adipocyte-derived endocrine factors, we found an plasma protein, adiponectin, that was decreased in obesity. We recently demonstrated adiponectin inhibited tumor necrosis factor-α (TNF-α)–induced expression of endothelial adhesion molecules and level reduced patients with coronary artery disease ( Circulation . 1999;100:2473–2476). However, intracellular signal by which suppressed molecule not elucidated. The present study investigated mechanism modulation for...
Insulin resistance and its dreaded consequence, type 2 diabetes, are major causes of atherosclerosis. Adiponectin is an adipose-specific plasma protein that possesses anti-atherogenic properties, such as the suppression adhesion molecule expression in vascular endothelial cells cytokine production from macrophages. Plasma adiponectin concentrations decreased obese diabetic subjects with insulin resistance. A regimen normalizes or increases might prevent atherosclerosis patients In this...
Adiponectin is an adipocyte-derived plasma protein that accumulates in the injured artery and has potential antiatherogenic properties. This study was designed to determine whether a decreased adiponectin level (hypoadiponectinemia) can be independently associated with prevalence of coronary disease (CAD). The consecutive 225 male patients were enrolled from inpatients who underwent angiography. Voluntary blood donors (n=225) matched for age served as controls. Plasma levels CAD...
Background —Excessive lipid accumulation in macrophages plays an important role the development of atherosclerosis. Recently, we discovered adipocyte-specific plasma protein, adiponectin, that is decreased patients with coronary artery disease. We previously demonstrated adiponectin acts as a modulator for proinflammatory stimuli and inhibits monocyte adhesion to endothelial cells. The present study investigated effects on human monocyte-derived macrophages. Methods Results —Human monocytes...
Dysregulation of adipocyte-derived bioactive molecules plays an important role in the development atherosclerosis. We previously reported that adiponectin, adipocyte-specific plasma protein, accumulated injured artery from and suppressed endothelial inflammatory response vascular smooth muscle cell proliferation, as well macrophage-to-foam transformation vitro. The current study investigated whether increased adiponectin could actually reduce atherosclerosis vivo.Apolipoprotein E-deficient...
Background— High-sensitive C-reactive protein (hs-CRP) is a well-known risk factor for coronary artery disease (CAD). Recently, we have demonstrated that adiponectin served as an antiatherogenic plasma which was secreted specifically from adipocytes. The present study investigated the association between and CRP in blood stream adipose tissue. Methods Results— We studied total of 101 male patients, 71 whom had angiographically documented atherosclerosis. As control group, 30 patients with...
Obesity is more linked to vascular disease, including atherosclerosis and restenotic change, after balloon angioplasty. The precise mechanism linking obesity disease still unclear. Previously we have demonstrated that the plasma levels of adiponectin, an adipose-derived hormone, decreases in obese subjects, hypoadiponectinemia associated ischemic heart disease. In current study, investigated vivo role adiponectin on neointimal thickening artery injury using adiponectin-deficient mice...
ABSTRACT. Adiponectin (ADPN), which is a secretory protein of adipose tissue, attenuates endothelial inflammatory responses in vitro. Among human subjects, plasma ADPN concentrations are reduced among patients with atherosclerotic complications but substantially increased advanced renal failure. The clinical and biochemical correlates levels were investigated the predictive power respect to survival rates cardiovascular events was prospectively tested cohort 227 hemodialysis patients, who...
Adiponectin is an adipocyte-specific adipocytokine with anti-atherogenic and anti-diabetic properties. Here, we investigated whether adiponectin regulates angiogenic processes in vitro vivo. stimulated the differentiation of human umbilical vein endothelium cells (HUVECs) into capillary-like structures functioned as a chemoattractant migration assays. promoted phosphorylation AMP-activated protein kinase (AMPK), Akt/protein B, endothelial nitric oxide synthesis (eNOS) HUVECs. Transduction...
Background — Vascular smooth muscle cell proliferation plays an important role in the development of atherosclerosis. We previously reported that adiponectin, adipocyte-specific plasma protein, accumulated human injured artery and suppressed endothelial inflammatory response as well macrophage-to-foam transformation. The present study investigated effects adiponectin on migration aortic cells (HASMCs). Methods Results HASMC was estimated by [ 3 H] thymidine uptake number. Cell assay...
Adiponectin is an adipocyte-derived, antiatherogenic protein that present in serum as three isoforms. Total adiponectin levels are decreased obese or diabetic humans animal models. This study was designed to elucidate the relative isoform distribution of human disease states and identify active form toward vascular endothelial cells. The percentage high molecular weight (HMW) per total significantly lower patients with coronary artery than control subjects, whereas hexamer similar trimer...
Adiponectin is one of the key molecules in metabolic syndrome, and its concentration decreased obesity, type-2 diabetes, coronary artery disease. Genetic investigation has revealed that 2 polymorphisms (I164T G276T) are related to adiponectin diabetes. To examine whether affects hypertension genetically or biologically, we performed a case-control study. A total 446 diagnosed cases (HT) men 312 normotensive (NT) were enrolled this Plasma was measured using an enzyme-linked immunosorbent...
Endothelial dysfunction is a crucial feature in the evolution of atherosclerosis. Adiponectin an adipocyte-specific plasma protein with antiatherogenic and antidiabetic properties. In present study, we investigated relation between adiponectin endothelium-dependent vasodilation. We analyzed endothelial function 202 hypertensive patients, including those who were not taking any medication. Forearm blood flow was measured by strain-gauge plethysmography. Plasma level highly correlated...
Adipose tissue secretes a variety of proteins into the bloodstream. We have previously reported novel cDNA, apM1 (adipose most abundant gene transcript 1), which is specifically and abundantly expressed in adipose [1]. Primary structure analysis predicted that product possesses significant homology to collagens VIII, X complement factor C1q, we named it adiponectin. In current study, analyzed characteristics adiponectin vitro vivo. Adiponectin protein was proved be secreted medium when cDNA...