A5009702941- Adipokines, Inflammation, and Metabolic Diseases
- melanin and skin pigmentation
- Skin Protection and Aging
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Advancements in Transdermal Drug Delivery
- Biochemical Analysis and Sensing Techniques
- Neuroscience and Neuropharmacology Research
- Dermatology and Skin Diseases
- Diabetes Treatment and Management
- Phytochemicals and Antioxidant Activities
- Dyeing and Modifying Textile Fibers
- Dermatologic Treatments and Research
- Contact Dermatitis and Allergies
- Metabolism, Diabetes, and Cancer
- Bee Products Chemical Analysis
- Diet, Metabolism, and Disease
- Mesenchymal stem cell research
- Acne and Rosacea Treatments and Effects
- Maternal Mental Health During Pregnancy and Postpartum
- Mast cells and histamine
- Hair Growth and Disorders
- Cytokine Signaling Pathways and Interactions
- Blood properties and coagulation
- Skin and Cellular Biology Research
University of Tsukuba
2025
Suita Municipal Hospital
2024
Tokyo University of Technology
2011-2024
Shikoku Medical Center for Children and Adults
2015-2024
Harvard University
2001-2023
Boston University
2006-2023
National Hospital Organization
2023
Sojo University
2021
Universidade de São Paulo
2018
Central Salt and Marine Chemicals Research Institute
2018
Abstract —Adiponectin is a novel, adipose-specific protein abundantly present in the circulation, and it has antiatherogenic properties. We analyzed plasma adiponectin concentrations age- body mass index (BMI)–matched nondiabetic type 2 diabetic subjects with without coronary artery disease (CAD). Plasma levels of CAD were lower than those (6.6±0.4 versus 7.9±0.5 μg/mL men, 7.6±0.7 11.7±1.0 women; P <0.001). The patients (4.0±0.4 6.6±0.4 μg/mL, <0.001 men; 6.3±0.8 women). In contrast,...
Among the many adipocyte-derived endocrine factors, we recently found an adipocyte-specific secretory protein, adiponectin, which was decreased in obesity. Although obesity is associated with increased cardiovascular mortality and morbidity, molecular basis for link between vascular disease has not been fully clarified. The present study investigated whether adiponectin could modulate endothelial function relate to coronary disease.For vitro study, human aortic cells (HAECs) were...
Background —Among the many adipocyte-derived endocrine factors, we found an plasma protein, adiponectin, that was decreased in obesity. We recently demonstrated adiponectin inhibited tumor necrosis factor-α (TNF-α)–induced expression of endothelial adhesion molecules and level reduced patients with coronary artery disease ( Circulation . 1999;100:2473–2476). However, intracellular signal by which suppressed molecule not elucidated. The present study investigated mechanism modulation for...
Background — Vascular smooth muscle cell proliferation plays an important role in the development of atherosclerosis. We previously reported that adiponectin, adipocyte-specific plasma protein, accumulated human injured artery and suppressed endothelial inflammatory response as well macrophage-to-foam transformation. The present study investigated effects adiponectin on migration aortic cells (HASMCs). Methods Results HASMC was estimated by [ 3 H] thymidine uptake number. Cell assay...
The delivery of autologous progenitor cells into ischemic tissue patients is emerging as a novel therapeutic option. Here, we report the potential impact cultured adipose tissue-derived (ADSC) on angiogenic cell therapy.ADSC were isolated from C57Bl/6 mouse inguinal and showed high expression ScaI CD44, but not c-kit, Lin, CD34, CD45, CD11b, CD31, compatible with that mesenchymal stem bone marrow. In coculture conditions ADSC human aortic endothelial (ECs) under treatment growth factors,...
Background— Vascular inflammation and subsequent matrix degradation play an important role in the development of atherosclerosis. We previously reported that adiponectin, adipose-specific plasma protein, accumulated to injured artery attenuated vascular inflammatory response. Clinically, high adiponectin level was associated with low cardiovascular event rate patients chronic renal failure. The present study designed elucidate effects on metalloproteinases (MMPs) tissue inhibitor (TIMPs)...
Arbutin, a naturally occurring beta-D-glucopyranoside of hydroquinone, is effective in the topical treatment various cutaneous hyperpigmentations characterized by hyperactive melanocyte function. We examined mechanism its depigmenting action human cultures. Arbutin inhibited tyrosinase activity cultured melanocytes at noncytotoxic concentrations. It did not affect expression mRNA. Melanin production was significantly arbutin, as determined measuring eumelanin radicals with an electron spin...
Patients with obesity are susceptible to hypertension. We have reported that the plasma adiponectin levels decreased in and has many defensive properties against obesity-related diseases, such as type 2 diabetes coronary artery disease. The aim of this study was determine relationship between hypertension mice. measured blood pressure heart rate directly by a catheter carotid indirectly automatic sphygmomanometer at tail artery. Obese KKAy mice had significantly lower higher systolic than...
We and others (1–9) have shown that the accumulation of visceral fat is associated with multiple risk factor syndrome more closely than BMI itself or amount subcutaneous fat. In these studies, computed tomography (CT) scan at umbilical level (10) was used for assessment area (VFA). However, method not cost-effective and/or radiation exposure problematic; thus, it often unsuitable screening large groups individuals. There a need simple noninvasive to assess accumulation. The bioelectrical...
The metabolic syndrome is a cluster of and inflammatory abnormalities including obesity, insulin resistance, type 2 diabetes, hypertension, dyslipidemia, atherosclerosis. fatty acid binding proteins aP2 (fatty protein [FABP]-4) mal1 (FABP5) are closely related both expressed in adipocytes. Previous studies aP2-deficient mice have indicated significant role for obesity-related However, the biological functions not known. Here, we report generation with targeted null mutations gene as well...
Normal human epidermal melanocytes became swollen and more dendritic with an increase in the amount of tyrosinase immunoreactive b ‐locus protein when they were cultured for 2 days following arachidonic acid metabolites: prostaglandin (PG) D , leukotriene (LT) B 4 LTC LTD LTE thromboxane (TX) 12‐hydroxy eicosatetraenoic (12‐HETE). The effect was particularly strong compared to that PGE about which we have previously reported. On other hand, 1 PGF 2α 6‐ketoPGF 1α did not show any significant...
Background— The adipocyte fatty acid-binding protein (FABP) aP2 is expressed by adipocytes and macrophages modulates insulin resistance, glucose lipid metabolism, atherosclerosis. Insulin sensitivity improved in obese but not lean aP2-deficient mice. A second protein, mal1, also macrophages, mal1 deficiency produces similar effects on resistance. We tested the hypothesis that combined would produce synergistic metabolism reduce atherosclerosis apolipoprotein E-deficient (apoE −/− ) Methods...
Objective— Fatty acids (FAs) are the major substrate for energy production in heart. Here, we hypothesize that capillary endothelial fatty acid binding protein 4 (FABP4) and FABP5 play an important role providing sufficient FAs to myocardium. Approach Results— Both FABP4/5 were abundantly expressed endothelium heart skeletal muscle. The uptake of a FA analogue, 125I-15-( p -iodophenyl)-3-(R,S)-methyl pentadecanoic acid, was significantly reduced these tissues double-knockout (DKO) mice...
The incidence of severe mucositis in the oral cavity, pharynx and larynx is high among patients with head neck cancer (HNC) receiving chemoradiotherapy (CRT), resulting significant pain impairment quality life. present study investigated whether L-glutamine (glutamine) decreases severity induced by CRT. This double-blind, randomized, placebo-controlled trial included 40 untreated squamous cell carcinoma nasopharynx, oropharynx, hypopharynx or larynx. Patients received 66 70 Gy total...
The adipocyte fatty acid-binding protein, aP2, has important effects on insulin resistance, lipid metabolism, and atherosclerosis. Its expression in macrophages enhances early foam cell formation atherosclerosis vivo. This study was designed to determine whether aP2 deficiency a similar effect the setting of advanced severe hypercholesterolemia.Mice deficient apolipoprotein E (aP2(-/-)apoE(-/-) mice) E-deficient control mice (apoE(-/-) were fed Western diet for 14 weeks. No significant...