- Adipose Tissue and Metabolism
- Hydrogen's biological and therapeutic effects
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Cardiac Fibrosis and Remodeling
- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Tissue Engineering and Regenerative Medicine
- Mitochondrial Function and Pathology
- Diabetes Treatment and Management
- Heart Failure Treatment and Management
- Cardiac Arrest and Resuscitation
- Pluripotent Stem Cells Research
- Cardiac electrophysiology and arrhythmias
- Congenital heart defects research
- Cytokine Signaling Pathways and Interactions
- Cardiac Valve Diseases and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Renal Diseases and Glomerulopathies
- RNA modifications and cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiomyopathy and Myosin Studies
- Cardiac pacing and defibrillation studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Hormonal Regulation and Hypertension
Keio University
2016-2025
Yamaguchi University
2024-2025
Saitama Medical University
2025
Advanced Neural Dynamics (United States)
2024
Keio University Hospital
2012-2023
Japan Science and Technology Agency
2009-2021
Nippon Veterinary and Life Science University
2020
Baylor College of Medicine
2002-2019
May Institute
2017
Institute of Cardiology
2016
Fibroblasts, which are the most numerous cell type in heart, interact with cardiomyocytes vitro and affect their function; however, they considered to play a secondary role cardiac hypertrophy failure. Here we have shown that fibroblasts essential for protective hypertrophic myocardial responses pressure overload vivo mice. Haploinsufficiency of transcription factor–encoding gene Krüppel-like factor 5 (Klf5) suppressed fibrosis elicited by moderate-intensity overload, whereas...
Rationale : The (pro)renin receptor [(P)RR], encoded in ATP6AP2 , plays a key role the activation of local renin-angiotensin system (RAS). A truncated form (P)RR, termed M8.9, was also found to be associated with vacuolar H + -ATPase (V-ATPase), implicating non–RAS-related function ATP6AP2. Objective We investigated (P)RR/ATP6AP2 murine cardiomyocytes. Methods and Results Cardiomyocyte-specific ablation Atp6ap2 resulted lethal heart failure; cardiomyocytes contained RAB7-...
Background— Inflammation and immune responses are integral components in the healing process after myocardial infarction. We previously reported dendritic cell (DC) infiltration infarcted heart; however, precise contribution of DC postinfarction is unclear. Methods Results— Bone marrow cells from CD11c-diphtheria toxin receptor/green fluorescent protein transgenic mice were transplanted into lethally irradiated wild-type recipient mice. After reconstitution bone marrow–derived cells, treated...
The semiquantitative Clinical Frailty Scale (CFS) is a simple tool to assess patients' frailty and has been shown correlate with mortality in elderly patients even when evaluated by nongeriatricians. aim of the current study was determine prognostic value CFS who underwent transcatheter aortic valve replacement.We utilized OCEAN (Optimized Catheter Valvular Intervention) Japanese multicenter registry review data 1215 replacement. Patients were categorized into 5 groups based on stages: 1-3,...
Chronic inflammation in visceral adipose tissue (VAT) precipitates the development of cardiometabolic disorders. Although changes T cell function associated with obesity are thought to affect chronic VAT inflammation, specific features these remain elusive. Here, we have determined that a high-fat diet (HFD) caused preferential increase and accumulation CD44hiCD62LloCD4+ cells constitutively express PD-1 CD153 B cell-dependent manner VAT. These possessed characteristics cellular senescence...
Both osteopontin (OPN) and galectin-3 have been implicated in phagocytic clearance of dead cells reparative fibrosis during wound healing. CD206+ macrophages are involved tissue repair through phagocytosis after myocardial infarction (MI). However, the relationship among OPN, galectin-3, macrophage polarization context MI remains unclear.The time course Spp1 (encoding OPN) expression heart showed a strong activation on day 3 MI. To identify where body which transcriptional activity increased...
Rationale: In-hospital outcomes are generally acceptable in patients with type B dissection; however, some present undesirable complications, such as aortic expansion and rupture. Excessive inflammation is an independent predictor of adverse clinical outcomes. Objective: We have investigated the underlying mechanisms catastrophic complications after acute dissection (AAD) mice. Methods Results: When angiotensin II was administered lysyl oxidase inhibitor–preconditioned mice, AAD emerged...
Medial arterial calcification is a chronic systemic vascular disorder distinct from atherosclerosis and commonly observed in patients with kidney disease, diabetes, aging individuals. We previously showed that NR4A3 (nuclear receptor subfamily 4 group A member 3), an orphan nuclear receptor, key regulator apo (apolipoprotein) A-IV-induced progression; however, its role poorly understood.
Abstract —This study was designed to determine whether mechanical stretch activates the Janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathway in cardiomyocytes and, if so, by what mechanism. Neonatal rat/murine were cultured on malleable silicone dishes stretched 20%. Mechanical induced rapid phosphorylation JAK1, JAK2, Tyk2, STAT1, STAT3, glycoprotein 130 as early 2 minutes peaked at 5 15 minutes. It also caused gel mobility shift sis-inducing element, which...
We recently reported that angiotensin II (Ang II) induced IL-6 mRNA expression in cardiac fibroblasts, which played an important role Ang II–induced hypertrophy paracrine fashion. The present study investigated the regulatory mechanism of gene expression, focusing especially on reactive oxygen species (ROS)-mediated signaling fibroblasts. increased intracellular ROS and increase was completely inhibited by AT-1 blocker candesartan NADH/NADPH oxidase inhibitor diphenyleneiodonium (DPI). first...
Acquisition of a cardiac fate by embryonic mesodermal cells is fundamental step in heart formation. Heart development frogs and avians requires positive signals from adjacent endoderm, including bone morphogenic proteins, antagonized second secreted signal, Wnt neural tube. By contrast, mechanisms commitment to create muscle mammals are largely unknown. In addition, Wnt-dependent can involve either canonical β-catenin pathway or other, alternative mediators. Here, we tested the involvement...